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Genetic Variant on Chromosome 12p13 Does Not Show Association to Ischemic Stroke in 3 Swedish Case-Control Studies

Olsson, Sandra; Melander, Olle LU ; Jood, Katarina; Smith, Gustav LU ; Lövkvist, Håkan LU ; Sjögren, Marketa LU ; Engström, Gunnar LU ; Norrving, Bo LU ; Lindgren, Arne LU and Jern, Christina (2011) In Stroke: a journal of cerebral circulation 42(1). p.214-216
Abstract
Background and Purpose-In a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden. Methods-We examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies. Results-No significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples... (More)
Background and Purpose-In a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden. Methods-We examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies. Results-No significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13). Conclusions-The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations. (Stroke. 2011;42:214-216.) (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
stroke, single-nucleotide polymorphism, genetic association studies
in
Stroke: a journal of cerebral circulation
volume
42
issue
1
pages
214 - 216
publisher
American Heart Association
external identifiers
  • wos:000285636400043
  • scopus:79451468882
ISSN
1524-4628
DOI
10.1161/STROKEAHA.110.594010
language
English
LU publication?
yes
id
8da49030-af23-4c4a-b1a6-0058485b3bb9 (old id 1790869)
date added to LUP
2011-03-02 13:38:12
date last changed
2017-01-01 06:01:23
@article{8da49030-af23-4c4a-b1a6-0058485b3bb9,
  abstract     = {Background and Purpose-In a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden. Methods-We examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies. Results-No significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13). Conclusions-The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations. (Stroke. 2011;42:214-216.)},
  author       = {Olsson, Sandra and Melander, Olle and Jood, Katarina and Smith, Gustav and Lövkvist, Håkan and Sjögren, Marketa and Engström, Gunnar and Norrving, Bo and Lindgren, Arne and Jern, Christina},
  issn         = {1524-4628},
  keyword      = {stroke,single-nucleotide polymorphism,genetic association studies},
  language     = {eng},
  number       = {1},
  pages        = {214--216},
  publisher    = {American Heart Association},
  series       = { Stroke: a journal of cerebral circulation},
  title        = {Genetic Variant on Chromosome 12p13 Does Not Show Association to Ischemic Stroke in 3 Swedish Case-Control Studies},
  url          = {http://dx.doi.org/10.1161/STROKEAHA.110.594010},
  volume       = {42},
  year         = {2011},
}