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Temporal trends of phthalate exposures during 2007–2010 in Swedish pregnant women

Shu, Huan; Jönsson, Bo A.G. LU ; Gennings, Chris; Svensson, Åke LU ; Nånberg, Eewa; Lindh, Christian H. LU ; Knutz, Malin; Takaro, Tim K. and Bornehag, Carl Gustaf LU (2018) In Journal of Exposure Science and Environmental Epidemiology p.1-11
Abstract

Background: The general population is exposed to phthalates, a group of chemicals with strong evidence for endocrine disrupting properties, commonly used in a large number of consumer products. Based on published research and evidence compiled by environmental agencies, certain phthalate applications and products have become restricted, leading to an increasing number of “new generation compounds” coming onto the market during recent years replacing older phthalates. Some examples of such newer compounds are di-iso-nonyl phthalate (DiNP), di-iso-decyl phthalate (DiDP), and most recently di-isononyl-cyclohexane-1,2-dicarboxylate (DiNCH). Objectives: In order to evaluate temporal trends in phthalate exposure, first trimester urinary... (More)

Background: The general population is exposed to phthalates, a group of chemicals with strong evidence for endocrine disrupting properties, commonly used in a large number of consumer products. Based on published research and evidence compiled by environmental agencies, certain phthalate applications and products have become restricted, leading to an increasing number of “new generation compounds” coming onto the market during recent years replacing older phthalates. Some examples of such newer compounds are di-iso-nonyl phthalate (DiNP), di-iso-decyl phthalate (DiDP), and most recently di-isononyl-cyclohexane-1,2-dicarboxylate (DiNCH). Objectives: In order to evaluate temporal trends in phthalate exposure, first trimester urinary biomarkers of phthalates were measured in the Swedish SELMA study over a period of 2.5 years (2007–2010). Methods: We collected first morning void urine samples around week 10 of pregnancy from 1651 pregnant women. Spot samples were analyzed for 13 phthalate metabolites and one phthalate replacement and least square geometric mean (LSGM) levels of the metabolites were compared between the sampling years when adjusted for potential confounders. Results: All 14 metabolites were detectable in more than 99% of the SELMA subjects. The levels were generally comparable to other studies, but the SELMA subjects showed slightly higher exposure to butyl-benzyl phthalate (BBzP) and di-butyl phthalate (DBP). Di-ethyl-hexyl phthalate (DEHP) metabolites levels decreased while DiNP, DiDP/di-2-propylheptyl phthalate (DPHP), and DiNCH metabolites levels increased during the sampling period. Conclusions: Urinary metabolite levels of the older phthalates and more recently introduced phthalate replacement compound changed during the short sampling period in this Swedish pregnancy cohort. Our results indicate that replacement of phthalates can make an impact on human exposure to these chemicals. During this particularly vulnerable stage of life, phthalate exposures are of particular concern as the impacts, though not immediately noticeable, may increase the risk for health effects later in life.

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author
organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
DiNCH, Endocrine disrupting chemicals, Exposure, Phthalates, Pregnant, SELMA-Study, Temporal
in
Journal of Exposure Science and Environmental Epidemiology
pages
11 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85042354826
ISSN
1559-0631
DOI
10.1038/s41370-018-0020-6
language
English
LU publication?
yes
id
18695d98-fd7f-46ed-8d51-74e1a089d5c7
date added to LUP
2018-03-12 09:25:28
date last changed
2018-05-29 09:52:33
@article{18695d98-fd7f-46ed-8d51-74e1a089d5c7,
  abstract     = {<p>Background: The general population is exposed to phthalates, a group of chemicals with strong evidence for endocrine disrupting properties, commonly used in a large number of consumer products. Based on published research and evidence compiled by environmental agencies, certain phthalate applications and products have become restricted, leading to an increasing number of “new generation compounds” coming onto the market during recent years replacing older phthalates. Some examples of such newer compounds are di-iso-nonyl phthalate (DiNP), di-iso-decyl phthalate (DiDP), and most recently di-isononyl-cyclohexane-1,2-dicarboxylate (DiNCH). Objectives: In order to evaluate temporal trends in phthalate exposure, first trimester urinary biomarkers of phthalates were measured in the Swedish SELMA study over a period of 2.5 years (2007–2010). Methods: We collected first morning void urine samples around week 10 of pregnancy from 1651 pregnant women. Spot samples were analyzed for 13 phthalate metabolites and one phthalate replacement and least square geometric mean (LSGM) levels of the metabolites were compared between the sampling years when adjusted for potential confounders. Results: All 14 metabolites were detectable in more than 99% of the SELMA subjects. The levels were generally comparable to other studies, but the SELMA subjects showed slightly higher exposure to butyl-benzyl phthalate (BBzP) and di-butyl phthalate (DBP). Di-ethyl-hexyl phthalate (DEHP) metabolites levels decreased while DiNP, DiDP/di-2-propylheptyl phthalate (DPHP), and DiNCH metabolites levels increased during the sampling period. Conclusions: Urinary metabolite levels of the older phthalates and more recently introduced phthalate replacement compound changed during the short sampling period in this Swedish pregnancy cohort. Our results indicate that replacement of phthalates can make an impact on human exposure to these chemicals. During this particularly vulnerable stage of life, phthalate exposures are of particular concern as the impacts, though not immediately noticeable, may increase the risk for health effects later in life.</p>},
  author       = {Shu, Huan and Jönsson, Bo A.G. and Gennings, Chris and Svensson, Åke and Nånberg, Eewa and Lindh, Christian H. and Knutz, Malin and Takaro, Tim K. and Bornehag, Carl Gustaf},
  issn         = {1559-0631},
  keyword      = {DiNCH,Endocrine disrupting chemicals,Exposure,Phthalates,Pregnant,SELMA-Study,Temporal},
  language     = {eng},
  month        = {02},
  pages        = {1--11},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Exposure Science and Environmental Epidemiology},
  title        = {Temporal trends of phthalate exposures during 2007–2010 in Swedish pregnant women},
  url          = {http://dx.doi.org/10.1038/s41370-018-0020-6},
  year         = {2018},
}