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Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study

Pincikova, T.; Nilsson, K.; Moen, I. E.; Karpati, F.; Fluge, G.; Hollsing, A.; Knudsen, P. K.; Lindblad, A.; Mared, Lena LU and Pressler, T., et al. (2011) In European Journal of Clinical Nutrition 65(1). p.102-109
Abstract
Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providing evidence of its benefit. In the context of the recently described immunomodulatory functions of vitamin D, we aimed to assess the relationship between vitamin D and IgG levels. Subjects/Methods: Eight hundred and ninety-six CF patients were included (0.53-65.9 years) from seven centers in Denmark, Norway and Sweden. Serum 25-hydroxyvitamin D (25OHD) and total IgG were measured, spirometry was carried out and vitamin D... (More)
Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providing evidence of its benefit. In the context of the recently described immunomodulatory functions of vitamin D, we aimed to assess the relationship between vitamin D and IgG levels. Subjects/Methods: Eight hundred and ninety-six CF patients were included (0.53-65.9 years) from seven centers in Denmark, Norway and Sweden. Serum 25-hydroxyvitamin D (25OHD) and total IgG were measured, spirometry was carried out and vitamin D intake data were gathered using a 7-day dietary food record. Multiple linear regression analyses were performed for IgG and forced expiratory volume in 1 lambda s (FEV1) as dependent variables, and serum 25OHD, daily food and supplemented vitamin D sources of intake as independent variables. The model was controlled for age, gender, genotype, CF-related diabetes, season, infection/colonization status, long-term oral corticosteroid treatment, long-term treatment with macrolide antibiotics, pancreatic insufficient phenotype and body mass index z-score. Results: Serum total IgG levels were negatively associated with serum 25OHD (adjusted R-2=0.376; beta = -0.02; P<0.001), supplemented vitamin D intake per kg bodyweight (adjusted R-2=0.375; beta = -0.82; P<0.001) and total vitamin D intake per kg bodyweight (adjusted R-2=0.398; beta = -0.60; P=0.002). Serum 25OHD was positively associated with FEV1 (adjusted R-2=0.308; beta=0.0007; P=0.025). Conclusions: Increasing vitamin D intake may positively modulate inflammation in CF. This study supports the proposed role of vitamin D in the immune system during infection and substantiates prospective studies. European Journal of Clinical Nutrition (2011) 65, 102-109; doi:10.1038/ejcn.2010.194; published online 22 September 2010 (Less)
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publication status
published
subject
keywords
cystic fibrosis, food, forced expiratory flow rates, immunity, immunoglobulin G, vitamin D
in
European Journal of Clinical Nutrition
volume
65
issue
1
pages
102 - 109
publisher
Nature Publishing Group
external identifiers
  • wos:000285960300016
  • scopus:78651099510
ISSN
1476-5640
DOI
10.1038/ejcn.2010.194
language
English
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yes
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b569e5b5-7b09-463f-9b90-ba73cf8d9b1e (old id 1869802)
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2011-04-04 08:56:49
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2017-11-12 03:37:05
@article{b569e5b5-7b09-463f-9b90-ba73cf8d9b1e,
  abstract     = {Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providing evidence of its benefit. In the context of the recently described immunomodulatory functions of vitamin D, we aimed to assess the relationship between vitamin D and IgG levels. Subjects/Methods: Eight hundred and ninety-six CF patients were included (0.53-65.9 years) from seven centers in Denmark, Norway and Sweden. Serum 25-hydroxyvitamin D (25OHD) and total IgG were measured, spirometry was carried out and vitamin D intake data were gathered using a 7-day dietary food record. Multiple linear regression analyses were performed for IgG and forced expiratory volume in 1 lambda s (FEV1) as dependent variables, and serum 25OHD, daily food and supplemented vitamin D sources of intake as independent variables. The model was controlled for age, gender, genotype, CF-related diabetes, season, infection/colonization status, long-term oral corticosteroid treatment, long-term treatment with macrolide antibiotics, pancreatic insufficient phenotype and body mass index z-score. Results: Serum total IgG levels were negatively associated with serum 25OHD (adjusted R-2=0.376; beta = -0.02; P&lt;0.001), supplemented vitamin D intake per kg bodyweight (adjusted R-2=0.375; beta = -0.82; P&lt;0.001) and total vitamin D intake per kg bodyweight (adjusted R-2=0.398; beta = -0.60; P=0.002). Serum 25OHD was positively associated with FEV1 (adjusted R-2=0.308; beta=0.0007; P=0.025). Conclusions: Increasing vitamin D intake may positively modulate inflammation in CF. This study supports the proposed role of vitamin D in the immune system during infection and substantiates prospective studies. European Journal of Clinical Nutrition (2011) 65, 102-109; doi:10.1038/ejcn.2010.194; published online 22 September 2010},
  author       = {Pincikova, T. and Nilsson, K. and Moen, I. E. and Karpati, F. and Fluge, G. and Hollsing, A. and Knudsen, P. K. and Lindblad, A. and Mared, Lena and Pressler, T. and Hjelte, L.},
  issn         = {1476-5640},
  keyword      = {cystic fibrosis,food,forced expiratory flow rates,immunity,immunoglobulin G,vitamin D},
  language     = {eng},
  number       = {1},
  pages        = {102--109},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Clinical Nutrition},
  title        = {Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study},
  url          = {http://dx.doi.org/10.1038/ejcn.2010.194},
  volume       = {65},
  year         = {2011},
}