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What Do Prostate Cancer Patients Die Of?

Riihimaeki, Matias; Thomsen, Hauke LU ; Brandt, Andreas LU ; Sundquist, Jan LU and Hemminki, Kari LU (2011) In Oncologist 16(2). p.175-181
Abstract
Background. A recent rise in the incidence of prostate cancer and a more favorable outcome have increased the proportions of other causes of death in affected men. Extending the survival of prostate cancer patients thus requires knowledge of all causes of death. Methods. Data on the population, cancers, and causes of death were gathered from the nationwide Swedish Family-Cancer Database. A Cox regression model, comparing prostate cancer patients with all other men, was applied. Hazard ratios (HR) were calculated both for the underlying cause and for dying with a specific cause listed among multiple causes of death. Findings. Among 686,500 observed deaths, 62,500 were prostate cancer patients. For underlying causes other than prostate... (More)
Background. A recent rise in the incidence of prostate cancer and a more favorable outcome have increased the proportions of other causes of death in affected men. Extending the survival of prostate cancer patients thus requires knowledge of all causes of death. Methods. Data on the population, cancers, and causes of death were gathered from the nationwide Swedish Family-Cancer Database. A Cox regression model, comparing prostate cancer patients with all other men, was applied. Hazard ratios (HR) were calculated both for the underlying cause and for dying with a specific cause listed among multiple causes of death. Findings. Among 686,500 observed deaths, 62,500 were prostate cancer patients. For underlying causes other than prostate cancer, the highest cause-specific HRs were found for external causes (HR, 1.24; 95% confidence interval [CI], 1.16-1.31), diseases of the pulmonary circulation (HR, 1.22; 95% CI, 1.09-1.37), and heart failure (HR, 1.18; 95% CI, 1.11-1.24). For specific multiple causes, the highest HRs were found for anemia (HR, 2.28; 95% CI, 2.14-2.42), diseases of the pulmonary circulation (HR, 1.61; 95% CI, 1.55-1.68), and urinary system disease (HR, 1.90; 95% CI, 1.84-1.96). Interpretations. Prostate cancer patients have a higher risk for dying from various causes other than prostate cancer, including external causes and heart failure. Mechanisms have been proposed linking these elevated risks to both cancer and treatment. More attention should be paid to comorbidities in men with prostate cancer. The present study fulfills a gap in the knowledge of death causes in prostate cancer patients. The Oncologist 2011; 16: 175-181 (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Oncologist
volume
16
issue
2
pages
175 - 181
publisher
AlphaMed Press
external identifiers
  • wos:000287698900006
  • scopus:79952596424
ISSN
1083-7159
DOI
10.1634/theoncologist.2010-0338
language
English
LU publication?
yes
id
d81c275a-1875-437c-8af2-42f6eba0f251 (old id 1872572)
date added to LUP
2011-04-04 08:11:53
date last changed
2017-10-01 04:03:22
@article{d81c275a-1875-437c-8af2-42f6eba0f251,
  abstract     = {Background. A recent rise in the incidence of prostate cancer and a more favorable outcome have increased the proportions of other causes of death in affected men. Extending the survival of prostate cancer patients thus requires knowledge of all causes of death. Methods. Data on the population, cancers, and causes of death were gathered from the nationwide Swedish Family-Cancer Database. A Cox regression model, comparing prostate cancer patients with all other men, was applied. Hazard ratios (HR) were calculated both for the underlying cause and for dying with a specific cause listed among multiple causes of death. Findings. Among 686,500 observed deaths, 62,500 were prostate cancer patients. For underlying causes other than prostate cancer, the highest cause-specific HRs were found for external causes (HR, 1.24; 95% confidence interval [CI], 1.16-1.31), diseases of the pulmonary circulation (HR, 1.22; 95% CI, 1.09-1.37), and heart failure (HR, 1.18; 95% CI, 1.11-1.24). For specific multiple causes, the highest HRs were found for anemia (HR, 2.28; 95% CI, 2.14-2.42), diseases of the pulmonary circulation (HR, 1.61; 95% CI, 1.55-1.68), and urinary system disease (HR, 1.90; 95% CI, 1.84-1.96). Interpretations. Prostate cancer patients have a higher risk for dying from various causes other than prostate cancer, including external causes and heart failure. Mechanisms have been proposed linking these elevated risks to both cancer and treatment. More attention should be paid to comorbidities in men with prostate cancer. The present study fulfills a gap in the knowledge of death causes in prostate cancer patients. The Oncologist 2011; 16: 175-181},
  author       = {Riihimaeki, Matias and Thomsen, Hauke and Brandt, Andreas and Sundquist, Jan and Hemminki, Kari},
  issn         = {1083-7159},
  language     = {eng},
  number       = {2},
  pages        = {175--181},
  publisher    = {AlphaMed Press},
  series       = {Oncologist},
  title        = {What Do Prostate Cancer Patients Die Of?},
  url          = {http://dx.doi.org/10.1634/theoncologist.2010-0338},
  volume       = {16},
  year         = {2011},
}