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Sociodemographic Factors, Nutritional Status, and Inflammatory Markers in Patients with Postural Orthostatic Tachycardia Syndrome

Tufvesson, Hanna LU orcid ; Hamrefors, Viktor LU orcid ; Roth, Bodil LU ; Fedorowski, Artur LU orcid and Ohlsson, Bodil LU (2023) In Acta Neurologica Scandinavica 2023.
Abstract

Objectives. Postural orthostatic tachycardia syndrome (POTS) is characterized by cardiovascular autonomic dysfunction of unknown etiology with high a prevalence of gastrointestinal symptoms. The aim of the present study was to examine sociodemographic, lifestyle, and nutritional factors as well as inflammatory markers in patients with POTS. Materials and Methods. Forty-three patients with POTS and 61 healthy controls completed questionnaires about sociodemographic factors, lifestyle habits, and gastrointestinal symptoms. Blood samples were analyzed for serum levels of cobalamins, folic acid, iron, total iron-binding capacity (TIBC), ferritin, sodium, potassium, magnesium, phosphorus, albumin, high-sensitive C-reactive protein (CRP), and... (More)

Objectives. Postural orthostatic tachycardia syndrome (POTS) is characterized by cardiovascular autonomic dysfunction of unknown etiology with high a prevalence of gastrointestinal symptoms. The aim of the present study was to examine sociodemographic, lifestyle, and nutritional factors as well as inflammatory markers in patients with POTS. Materials and Methods. Forty-three patients with POTS and 61 healthy controls completed questionnaires about sociodemographic factors, lifestyle habits, and gastrointestinal symptoms. Blood samples were analyzed for serum levels of cobalamins, folic acid, iron, total iron-binding capacity (TIBC), ferritin, sodium, potassium, magnesium, phosphorus, albumin, high-sensitive C-reactive protein (CRP), and 25-hydroxyvitamin D (25-OH vitamin D). Results. POTS patients were predominantly women with a lower education level and were more often working part-time, on sick leave, and living alone compared with healthy controls. They reported lower alcohol intake and physical activity levels than controls. The nutrient intake was in general similar in both groups, but POTS patients had a higher intake of different drinks and reported more gastrointestinal symptoms than controls. POTS was associated with higher CRP levels (β: 1.370; 95% CI: 0.004-2.737; p=0.049), lower albumin levels (β: -1.443; 95% CI: -2.648-(-0.238); p=0.019), and higher sodium levels (β: 1.392; 95% CI: 0.559-2.225; p=0.001). Abdominal pain (p=0.004) and intestinal symptoms' influence on daily life (p=0.025) were negatively associated with albumin levels. Abdominal pain (p=0.011), vomiting and nausea (p=0.003), and intestinal symptoms' influence on daily life (p=0.026) were associated with higher sodium levels. Serum levels representing iron and vitamin metabolism were equal between groups. Conclusions. POTS is associated with poorer sociodemographic status, but malnutrition cannot explain POTS or related gastrointestinal symptoms. Higher CRP and lower albumin levels suggest low-grade inflammation as one possible etiological factor.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Neurologica Scandinavica
volume
2023
article number
3992718
publisher
Wiley-Blackwell
external identifiers
  • scopus:85172159308
ISSN
0001-6314
DOI
10.1155/2023/3992718
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2023 Hanna Tufvesson et al.
id
194f4bb2-c37a-4999-aac5-b0ba9233a639
date added to LUP
2023-11-20 09:02:28
date last changed
2024-02-16 20:02:59
@article{194f4bb2-c37a-4999-aac5-b0ba9233a639,
  abstract     = {{<p>Objectives. Postural orthostatic tachycardia syndrome (POTS) is characterized by cardiovascular autonomic dysfunction of unknown etiology with high a prevalence of gastrointestinal symptoms. The aim of the present study was to examine sociodemographic, lifestyle, and nutritional factors as well as inflammatory markers in patients with POTS. Materials and Methods. Forty-three patients with POTS and 61 healthy controls completed questionnaires about sociodemographic factors, lifestyle habits, and gastrointestinal symptoms. Blood samples were analyzed for serum levels of cobalamins, folic acid, iron, total iron-binding capacity (TIBC), ferritin, sodium, potassium, magnesium, phosphorus, albumin, high-sensitive C-reactive protein (CRP), and 25-hydroxyvitamin D (25-OH vitamin D). Results. POTS patients were predominantly women with a lower education level and were more often working part-time, on sick leave, and living alone compared with healthy controls. They reported lower alcohol intake and physical activity levels than controls. The nutrient intake was in general similar in both groups, but POTS patients had a higher intake of different drinks and reported more gastrointestinal symptoms than controls. POTS was associated with higher CRP levels (β: 1.370; 95% CI: 0.004-2.737; p=0.049), lower albumin levels (β: -1.443; 95% CI: -2.648-(-0.238); p=0.019), and higher sodium levels (β: 1.392; 95% CI: 0.559-2.225; p=0.001). Abdominal pain (p=0.004) and intestinal symptoms' influence on daily life (p=0.025) were negatively associated with albumin levels. Abdominal pain (p=0.011), vomiting and nausea (p=0.003), and intestinal symptoms' influence on daily life (p=0.026) were associated with higher sodium levels. Serum levels representing iron and vitamin metabolism were equal between groups. Conclusions. POTS is associated with poorer sociodemographic status, but malnutrition cannot explain POTS or related gastrointestinal symptoms. Higher CRP and lower albumin levels suggest low-grade inflammation as one possible etiological factor.</p>}},
  author       = {{Tufvesson, Hanna and Hamrefors, Viktor and Roth, Bodil and Fedorowski, Artur and Ohlsson, Bodil}},
  issn         = {{0001-6314}},
  language     = {{eng}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Neurologica Scandinavica}},
  title        = {{Sociodemographic Factors, Nutritional Status, and Inflammatory Markers in Patients with Postural Orthostatic Tachycardia Syndrome}},
  url          = {{http://dx.doi.org/10.1155/2023/3992718}},
  doi          = {{10.1155/2023/3992718}},
  volume       = {{2023}},
  year         = {{2023}},
}