Health-related quality of life in multiple system atrophy
(2006) In Movement Disorders 21(6). p.809-815- Abstract
- Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-513, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale... (More)
- Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-513, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI >= 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease. (c) 2006 Movement Disorder Society. (Less)
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- author
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- health-related quality of life, multiple system atrophy, autonomic dysfunction, depression
- in
- Movement Disorders
- volume
- 21
- issue
- 6
- pages
- 809 - 815
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:16502399
- wos:000238560700012
- scopus:33745869469
- ISSN
- 0885-3185
- DOI
- 10.1002/mds.20808
- language
- English
- LU publication?
- yes
- id
- 1a6c1a35-7c9d-44fd-bbd7-aeeaa419be59 (old id 404793)
- date added to LUP
- 2016-04-01 11:42:23
- date last changed
- 2022-01-26 17:00:45
@article{1a6c1a35-7c9d-44fd-bbd7-aeeaa419be59,
abstract = {{Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-513, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI >= 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease. (c) 2006 Movement Disorder Society.}},
author = {{Schrag, A and Geser, F and Stampfer-Kountchev, M and Seppi, K and Sawires, M and Kollensperger, M and Scherfler, C and Quinn, N and Pellecchia, MT and Barone, P and del Sorbo, F and Albanese, A and Ostergaard, K and Dupont, E and Cardozo, A and Tolosa, E and Nilsson, C and Widner, Håkan and Lindvall, Olle and Giladi, N and Gurevich, T and Daniels, C and Deuschl, G and Coelho, M and Sampaio, C and Abele, M and Klockgether, T and Schimke, N and Eggert, KM and Oertel, W and Djaldetti, R and Colosimo, C and Meco, G and Poewe, W and Wenning, GK}},
issn = {{0885-3185}},
keywords = {{health-related quality of life; multiple system atrophy; autonomic dysfunction; depression}},
language = {{eng}},
number = {{6}},
pages = {{809--815}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Movement Disorders}},
title = {{Health-related quality of life in multiple system atrophy}},
url = {{http://dx.doi.org/10.1002/mds.20808}},
doi = {{10.1002/mds.20808}},
volume = {{21}},
year = {{2006}},
}