Actively controlled cardiac afterload
Pigot, Harry LU
; Wahlquist, Ylva
LU
and Soltesz, Kristian
LU
(2023)
22nd IFAC World Congress
In IFAC Proceedings Volumes (IFAC-PapersOnline)
56(2).
p.6484-6489
- Abstract
- Ex vivo (outside of the body) working heart models enable the evaluation of isolated hearts. They are envisioned to play an important role in increasing the currently low utilization rate of donor hearts for transplantation. For the heart to work in isolation, an afterload (flow impedance) is needed. To date, afterload devices have been constructed by combining multiple constituent elements such as pumps, flow resistances, and flow capacitances (compliances), typically to replicate the structure of so-called Windkessel models. This limits active control to that achievable by varying these elements, making it slow and subject to the problem of dynamic coupling between parameters. Here we present a novel concept to achieve Windkessel... (More)
- Ex vivo (outside of the body) working heart models enable the evaluation of isolated hearts. They are envisioned to play an important role in increasing the currently low utilization rate of donor hearts for transplantation. For the heart to work in isolation, an afterload (flow impedance) is needed. To date, afterload devices have been constructed by combining multiple constituent elements such as pumps, flow resistances, and flow capacitances (compliances), typically to replicate the structure of so-called Windkessel models. This limits active control to that achievable by varying these elements, making it slow and subject to the problem of dynamic coupling between parameters. Here we present a novel concept to achieve Windkessel dynamics through a very simple variable flow impedance. The impedance is actively controlled using feedback from a pressure measurement. Through simulations we demonstrate the ability to perfectly emulate Windkessel dynamics, while imposing tight pressure limits needed for safe operation—something not achievable with the verbatim implementation using constituent elements. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1af5e4f8-5aeb-47cc-be55-97ab4a793ecd
- author
- Pigot, Harry
LU
; Wahlquist, Ylva
LU
and Soltesz, Kristian
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- artificial organ, physiological modelling, control of physiological and clinical variables
- in
- IFAC Proceedings Volumes (IFAC-PapersOnline)
- volume
- 56
- issue
- 2
- pages
- 6484 - 6489
- publisher
- IFAC Secretariat
- conference name
- 22nd IFAC World Congress
- conference location
- Yokohama, Japan
- conference dates
- 2023-07-09 - 2023-07-14
- external identifiers
-
- scopus:85183667193
- ISSN
- 2405-8963
- DOI
- 10.1016/j.ifacol.2023.10.863
- project
- Functional ex vivo heart evaluation
- Hemodynamic Stabilization
- language
- English
- LU publication?
- yes
- id
- 1af5e4f8-5aeb-47cc-be55-97ab4a793ecd
- date added to LUP
- 2023-03-04 14:31:45
- date last changed
- 2024-04-29 03:47:40
@article{1af5e4f8-5aeb-47cc-be55-97ab4a793ecd,
abstract = {{<i>Ex vivo</i> (outside of the body) working heart models enable the evaluation of isolated hearts. They are envisioned to play an important role in increasing the currently low utilization rate of donor hearts for transplantation. For the heart to work in isolation, an afterload (flow impedance) is needed. To date, afterload devices have been constructed by combining multiple constituent elements such as pumps, flow resistances, and flow capacitances (compliances), typically to replicate the structure of so-called Windkessel models. This limits active control to that achievable by varying these elements, making it slow and subject to the problem of dynamic coupling between parameters. Here we present a novel concept to achieve Windkessel dynamics through a very simple variable flow impedance. The impedance is actively controlled using feedback from a pressure measurement. Through simulations we demonstrate the ability to perfectly emulate Windkessel dynamics, while imposing tight pressure limits needed for safe operation—something not achievable with the verbatim implementation using constituent elements.}},
author = {{Pigot, Harry and Wahlquist, Ylva and Soltesz, Kristian}},
issn = {{2405-8963}},
keywords = {{artificial organ; physiological modelling; control of physiological and clinical variables}},
language = {{eng}},
number = {{2}},
pages = {{6484--6489}},
publisher = {{IFAC Secretariat}},
series = {{IFAC Proceedings Volumes (IFAC-PapersOnline)}},
title = {{Actively controlled cardiac afterload}},
url = {{https://lup.lub.lu.se/search/files/147414618/230323_ifac23_final_submission.pdf}},
doi = {{10.1016/j.ifacol.2023.10.863}},
volume = {{56}},
year = {{2023}},
}