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Bariatric surgery enhances splanchnic vascular responses in patients with type 2 diabetes

Honka, Henri; Koffert, Jukka; Kauhanen, Saila; Teuho, Jarmo; Hurme, Saija; Mari, Andrea; Lindqvist, Andreas LU ; Wierup, Nils LU ; Groop, Leif LU and Nuutila, Pirjo (2017) In Diabetes 66(4). p.880-885
Abstract

Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixedmeal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were carried out on two separate days. Pancreatic and intestinal blood flow (BF) were measured at baseline, 20 min, and 50 min with 15O-water by using positron emission tomography and MRI. Before surgery, pancreatic and intestinal BF responses to a mixed meal did not differ between obese and lean control subjects. Compared with... (More)

Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixedmeal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were carried out on two separate days. Pancreatic and intestinal blood flow (BF) were measured at baseline, 20 min, and 50 min with 15O-water by using positron emission tomography and MRI. Before surgery, pancreatic and intestinal BF responses to a mixed meal did not differ between obese and lean control subjects. Compared with presurgery, the mixed meal induced a greater increase in plasma glucose, insulin, and GIP concentrations after surgery, which was accompanied by a marked augmentation of pancreatic and intestinal BF responses. GIP infusion decreased pancreatic but increased small intestinal BF similarly in all groups both before and after surgery. Taken together, these results demonstrate that bariatric surgery leads to enhanced splanchnic vascular responses as a likely consequence of rapid glucose appearance and GIP hypersecretion.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
66
issue
4
pages
6 pages
publisher
American Diabetes Association Inc.
external identifiers
  • scopus:85019636413
  • wos:000397114900012
ISSN
0012-1797
DOI
10.2337/db16-0762
language
English
LU publication?
yes
id
1df68263-f94f-47ed-bc8e-9e5a34e209d5
date added to LUP
2017-07-03 18:05:22
date last changed
2018-01-07 12:10:19
@article{1df68263-f94f-47ed-bc8e-9e5a34e209d5,
  abstract     = {<p>Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixedmeal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were carried out on two separate days. Pancreatic and intestinal blood flow (BF) were measured at baseline, 20 min, and 50 min with <sup>15</sup>O-water by using positron emission tomography and MRI. Before surgery, pancreatic and intestinal BF responses to a mixed meal did not differ between obese and lean control subjects. Compared with presurgery, the mixed meal induced a greater increase in plasma glucose, insulin, and GIP concentrations after surgery, which was accompanied by a marked augmentation of pancreatic and intestinal BF responses. GIP infusion decreased pancreatic but increased small intestinal BF similarly in all groups both before and after surgery. Taken together, these results demonstrate that bariatric surgery leads to enhanced splanchnic vascular responses as a likely consequence of rapid glucose appearance and GIP hypersecretion.</p>},
  author       = {Honka, Henri and Koffert, Jukka and Kauhanen, Saila and Teuho, Jarmo and Hurme, Saija and Mari, Andrea and Lindqvist, Andreas and Wierup, Nils and Groop, Leif and Nuutila, Pirjo},
  issn         = {0012-1797},
  language     = {eng},
  month        = {04},
  number       = {4},
  pages        = {880--885},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {Bariatric surgery enhances splanchnic vascular responses in patients with type 2 diabetes},
  url          = {http://dx.doi.org/10.2337/db16-0762},
  volume       = {66},
  year         = {2017},
}