Bariatric surgery enhances splanchnic vascular responses in patients with type 2 diabetes
(2017) In Diabetes 66(4). p.880-885- Abstract
Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixedmeal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were carried out on two separate days. Pancreatic and intestinal blood flow (BF) were measured at baseline, 20 min, and 50 min with 15O-water by using positron emission tomography and MRI. Before surgery, pancreatic and intestinal BF responses to a mixed meal did not differ between obese and lean control subjects. Compared with... (More)
Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixedmeal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were carried out on two separate days. Pancreatic and intestinal blood flow (BF) were measured at baseline, 20 min, and 50 min with 15O-water by using positron emission tomography and MRI. Before surgery, pancreatic and intestinal BF responses to a mixed meal did not differ between obese and lean control subjects. Compared with presurgery, the mixed meal induced a greater increase in plasma glucose, insulin, and GIP concentrations after surgery, which was accompanied by a marked augmentation of pancreatic and intestinal BF responses. GIP infusion decreased pancreatic but increased small intestinal BF similarly in all groups both before and after surgery. Taken together, these results demonstrate that bariatric surgery leads to enhanced splanchnic vascular responses as a likely consequence of rapid glucose appearance and GIP hypersecretion.
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- author
- Honka, Henri ; Koffert, Jukka ; Kauhanen, Saila ; Teuho, Jarmo ; Hurme, Saija ; Mari, Andrea ; Lindqvist, Andreas LU ; Wierup, Nils LU ; Groop, Leif LU and Nuutila, Pirjo
- organization
- publishing date
- 2017-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 66
- issue
- 4
- pages
- 6 pages
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- pmid:28096259
- wos:000397114900012
- scopus:85019636413
- ISSN
- 0012-1797
- DOI
- 10.2337/db16-0762
- language
- English
- LU publication?
- yes
- id
- 1df68263-f94f-47ed-bc8e-9e5a34e209d5
- date added to LUP
- 2017-07-03 18:05:22
- date last changed
- 2025-02-18 22:16:44
@article{1df68263-f94f-47ed-bc8e-9e5a34e209d5, abstract = {{<p>Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixedmeal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were carried out on two separate days. Pancreatic and intestinal blood flow (BF) were measured at baseline, 20 min, and 50 min with <sup>15</sup>O-water by using positron emission tomography and MRI. Before surgery, pancreatic and intestinal BF responses to a mixed meal did not differ between obese and lean control subjects. Compared with presurgery, the mixed meal induced a greater increase in plasma glucose, insulin, and GIP concentrations after surgery, which was accompanied by a marked augmentation of pancreatic and intestinal BF responses. GIP infusion decreased pancreatic but increased small intestinal BF similarly in all groups both before and after surgery. Taken together, these results demonstrate that bariatric surgery leads to enhanced splanchnic vascular responses as a likely consequence of rapid glucose appearance and GIP hypersecretion.</p>}}, author = {{Honka, Henri and Koffert, Jukka and Kauhanen, Saila and Teuho, Jarmo and Hurme, Saija and Mari, Andrea and Lindqvist, Andreas and Wierup, Nils and Groop, Leif and Nuutila, Pirjo}}, issn = {{0012-1797}}, language = {{eng}}, month = {{04}}, number = {{4}}, pages = {{880--885}}, publisher = {{American Diabetes Association Inc.}}, series = {{Diabetes}}, title = {{Bariatric surgery enhances splanchnic vascular responses in patients with type 2 diabetes}}, url = {{http://dx.doi.org/10.2337/db16-0762}}, doi = {{10.2337/db16-0762}}, volume = {{66}}, year = {{2017}}, }