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Association between PSA Levels and Biomarkers of Subclinical Systemic Inflammation in Middle-Aged Healthy Men from the General Population

Elzanaty, Saad LU ; REZANEZHAD ZANJANI, BABAK LU and Borgquist, Rasmus LU (2016) In Current Urology 9(3). p.148-152
Abstract

Introduction: This study was aimed to determine the association between PSA levels and biomarkers of subclinical systemic inflammation based on data from 119 middle-aged healthy men from the general population. Materials and Methods: Serum levels of PSA and biomarkers of systemic inflammation (CRP and fibrinogen) were measured. Demographic data were also collected. Subjects were divided into two groups according to PSA levels; < 2 ng/ml and ≥ 2 ng/ml. Results: The mean (SD) age of men was 55 ± 4.0 years. We found a positive significant correlation between PSA and fibrinogen levels (r = 0.20, p = 0.04), and between CRP and fibrinogen levels (r = 0.60, p = 0.01). On the other hand, no significant correlation between PSA and CRP levels... (More)

Introduction: This study was aimed to determine the association between PSA levels and biomarkers of subclinical systemic inflammation based on data from 119 middle-aged healthy men from the general population. Materials and Methods: Serum levels of PSA and biomarkers of systemic inflammation (CRP and fibrinogen) were measured. Demographic data were also collected. Subjects were divided into two groups according to PSA levels; < 2 ng/ml and ≥ 2 ng/ml. Results: The mean (SD) age of men was 55 ± 4.0 years. We found a positive significant correlation between PSA and fibrinogen levels (r = 0.20, p = 0.04), and between CRP and fibrinogen levels (r = 0.60, p = 0.01). On the other hand, no significant correlation between PSA and CRP levels was found. Men with PSA values ≥ 2 ng/ml had significantly higher levels of fibrinogen as compared to those with PSA < 2 ng/ml (2.9 ng/ml vs. 2.4 ng/ml, p = 0.01). In a multivariate regression analysis model adjusted for the age of subjects, BMI, marital status, smoking, snuff, and alcohol intake with serum levels of PSA as a dependent variable, serum level of fibrinogen predicted higher PSA-values (odds ratio = 3.30, 95% CI = 1.05-10.20, p = 0.042). Conclusions: The present results indicate that serum fibrinogen is a biomarker of subclinical systemic inflammation associated with PSA elevation among middle-aged healthy men from the general population.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CRP, Fibrinogen, Prostate cancer, PSA, Systemic inflammation
in
Current Urology
volume
9
issue
3
pages
5 pages
publisher
S. Karger AG
external identifiers
  • scopus:84992358076
ISSN
1661-7649
DOI
10.1159/000442870
language
English
LU publication?
yes
id
1e1d5273-56a4-4097-9d24-161d54bb44a6
date added to LUP
2016-11-15 14:46:03
date last changed
2017-06-11 05:10:20
@article{1e1d5273-56a4-4097-9d24-161d54bb44a6,
  abstract     = {<p>Introduction: This study was aimed to determine the association between PSA levels and biomarkers of subclinical systemic inflammation based on data from 119 middle-aged healthy men from the general population. Materials and Methods: Serum levels of PSA and biomarkers of systemic inflammation (CRP and fibrinogen) were measured. Demographic data were also collected. Subjects were divided into two groups according to PSA levels; &lt; 2 ng/ml and ≥ 2 ng/ml. Results: The mean (SD) age of men was 55 ± 4.0 years. We found a positive significant correlation between PSA and fibrinogen levels (r = 0.20, p = 0.04), and between CRP and fibrinogen levels (r = 0.60, p = 0.01). On the other hand, no significant correlation between PSA and CRP levels was found. Men with PSA values ≥ 2 ng/ml had significantly higher levels of fibrinogen as compared to those with PSA &lt; 2 ng/ml (2.9 ng/ml vs. 2.4 ng/ml, p = 0.01). In a multivariate regression analysis model adjusted for the age of subjects, BMI, marital status, smoking, snuff, and alcohol intake with serum levels of PSA as a dependent variable, serum level of fibrinogen predicted higher PSA-values (odds ratio = 3.30, 95% CI = 1.05-10.20, p = 0.042). Conclusions: The present results indicate that serum fibrinogen is a biomarker of subclinical systemic inflammation associated with PSA elevation among middle-aged healthy men from the general population.</p>},
  author       = {Elzanaty, Saad and REZANEZHAD ZANJANI, BABAK and Borgquist, Rasmus},
  issn         = {1661-7649},
  keyword      = {CRP,Fibrinogen,Prostate cancer,PSA,Systemic inflammation},
  language     = {eng},
  month        = {10},
  number       = {3},
  pages        = {148--152},
  publisher    = {S. Karger AG},
  series       = {Current Urology},
  title        = {Association between PSA Levels and Biomarkers of Subclinical Systemic Inflammation in Middle-Aged Healthy Men from the General Population},
  url          = {http://dx.doi.org/10.1159/000442870},
  volume       = {9},
  year         = {2016},
}