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Work disability in non-radiographic axial spondyloarthritis patients before and after start of anti-TNF therapy : A population-based regional cohort study from southern Sweden

KARLSSON WALLMAN, JOHAN LU ; Jöud, Anna LU ; Olofsson, Tor LU ; Jacobsson, Lennart T.H. LU ; Bliddal, Henning and Kristensen, Lars E. LU (2017) In Rheumatology 56(5). p.716-724
Abstract

Objective. The aim was to assess work-loss days before and after commencement of anti-TNF treatment in patients with non-radiographic axial spondylarthritis (nr-axSpA). Methods. Bionaïve nr-axSpA patients (n = 75), aged 17-62 years, fulfilling the Assessment of SpondyloArthritis international Society criteria for axial spondyloarthritis and starting anti-TNF treatment during 2004-11, were retrieved from the observational South Swedish Arthritis Treatment Group study. Patient information was linked to Swedish Social Insurance Agency data on sick leave and disability pension from 1 year before to 2 years after anti-TNF initiation. Matched population references were included for comparison and to adjust for secular trends. Results. The... (More)

Objective. The aim was to assess work-loss days before and after commencement of anti-TNF treatment in patients with non-radiographic axial spondylarthritis (nr-axSpA). Methods. Bionaïve nr-axSpA patients (n = 75), aged 17-62 years, fulfilling the Assessment of SpondyloArthritis international Society criteria for axial spondyloarthritis and starting anti-TNF treatment during 2004-11, were retrieved from the observational South Swedish Arthritis Treatment Group study. Patient information was linked to Swedish Social Insurance Agency data on sick leave and disability pension from 1 year before to 2 years after anti-TNF initiation. Matched population references were included for comparison and to adjust for secular trends. Results. The nr-axSpA patients had a median age of 35 years and disease duration of 6 years at the start of treatment. During the 2 years after anti-TNF initiation, mean work-loss days (including both sick leave and disability pension) in the nr-axSpA group decreased significantly from 3.4 to 1.9 times more than among the population references. The effect was seen on sick leave, whereas disability pension levels remained similar in both groups throughout. Conclusion. Anti-TNF therapy in nr-axSpA was associated with a significant and sustained improvement of work disability over 2 years. However, the proportion of work-loss days remained almost twice as high as in the general population at the end of follow-up.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anti-TNF treatment, Biologic treatment, Disability pension, Non-radiographic axial spondyloarthritis, Sick leave, Spondyloarthritis, Work disability
in
Rheumatology
volume
56
issue
5
pages
9 pages
publisher
Oxford University Press
external identifiers
  • scopus:85019686858
  • wos:000402143000009
ISSN
1462-0324
DOI
10.1093/rheumatology/kew473
language
English
LU publication?
yes
id
1e522176-c31c-432c-b6fd-ad79bc2fccf7
date added to LUP
2017-07-03 16:48:32
date last changed
2017-09-18 11:37:22
@article{1e522176-c31c-432c-b6fd-ad79bc2fccf7,
  abstract     = {<p>Objective. The aim was to assess work-loss days before and after commencement of anti-TNF treatment in patients with non-radiographic axial spondylarthritis (nr-axSpA). Methods. Bionaïve nr-axSpA patients (n = 75), aged 17-62 years, fulfilling the Assessment of SpondyloArthritis international Society criteria for axial spondyloarthritis and starting anti-TNF treatment during 2004-11, were retrieved from the observational South Swedish Arthritis Treatment Group study. Patient information was linked to Swedish Social Insurance Agency data on sick leave and disability pension from 1 year before to 2 years after anti-TNF initiation. Matched population references were included for comparison and to adjust for secular trends. Results. The nr-axSpA patients had a median age of 35 years and disease duration of 6 years at the start of treatment. During the 2 years after anti-TNF initiation, mean work-loss days (including both sick leave and disability pension) in the nr-axSpA group decreased significantly from 3.4 to 1.9 times more than among the population references. The effect was seen on sick leave, whereas disability pension levels remained similar in both groups throughout. Conclusion. Anti-TNF therapy in nr-axSpA was associated with a significant and sustained improvement of work disability over 2 years. However, the proportion of work-loss days remained almost twice as high as in the general population at the end of follow-up.</p>},
  author       = {KARLSSON WALLMAN, JOHAN and Jöud, Anna and Olofsson, Tor and Jacobsson, Lennart T.H. and Bliddal, Henning and Kristensen, Lars E.},
  issn         = {1462-0324},
  keyword      = {Anti-TNF treatment,Biologic treatment,Disability pension,Non-radiographic axial spondyloarthritis,Sick leave,Spondyloarthritis,Work disability},
  language     = {eng},
  month        = {05},
  number       = {5},
  pages        = {716--724},
  publisher    = {Oxford University Press},
  series       = {Rheumatology},
  title        = {Work disability in non-radiographic axial spondyloarthritis patients before and after start of anti-TNF therapy : A population-based regional cohort study from southern Sweden},
  url          = {http://dx.doi.org/10.1093/rheumatology/kew473},
  volume       = {56},
  year         = {2017},
}