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Maternal Autoimmune Thyroid Disease and the Fetal Immune System.

Svensson, J; Oderup, C; Silver, Christina LU ; Uvebrant, K; Hallengren, Bengt LU ; Ericsson, U B; Arvastsson, Jeanette LU ; Danska, J S; Lantz, Mikael LU and Cilio, Corrado LU (2011) In Experimental and Clinical Endocrinology & Diabetes 119(7). p.445-450
Abstract
OBJECTIVE: Several studies indicate that in utero exposure to maternal autoimmune diseases and transplacental passage of autoantibodies affect the risk of autoimmunity in the offspring, e. g., maternally derived GAD65 autoantibody correlates with decreased risk of type 1 diabetes, whereas thyroid peroxidase autoantibody (TPOAb) positivity at birth is associated with increased incidence of autoimmune thyroid disease later in life. The aim of this study was to identify immunological changes in children born to mothers with thyroid autoimmunity that may be related to in utero exposure to autoantibodies. DESIGN AND METHOD: Open label prospective analysis of cord blood lymphocytes and serum cytokines by Flow Cytometry in children born to... (More)
OBJECTIVE: Several studies indicate that in utero exposure to maternal autoimmune diseases and transplacental passage of autoantibodies affect the risk of autoimmunity in the offspring, e. g., maternally derived GAD65 autoantibody correlates with decreased risk of type 1 diabetes, whereas thyroid peroxidase autoantibody (TPOAb) positivity at birth is associated with increased incidence of autoimmune thyroid disease later in life. The aim of this study was to identify immunological changes in children born to mothers with thyroid autoimmunity that may be related to in utero exposure to autoantibodies. DESIGN AND METHOD: Open label prospective analysis of cord blood lymphocytes and serum cytokines by Flow Cytometry in children born to mothers with autoimmune thyroiditis (AIT) (n=31) and to healthy mothers (n=76) and titers of thyroid autoantibodies were determined in cord blood and in maternal peripheral blood at delivery. RESULTS: We found an increase (almost 30%) in the frequency of cord blood natural killer (NK) cells (p=0.0016) and a minor increase in the subset of T cells expressing NK markers (p=0.028), in children born to AIT mothers. There were no detectable differences in the phenotype or frequency of cord blood memory/activated T cells, including CD4 (+)CD25 (+) T cells, between the 2 groups. The levels of pro-inflammatory cytokines TNF-α, IL-10, IL-12p70, IFN-γ and IL-1β were significantly decreased in offspring of AIT mothers as compared to healthy controls. CONCLUSIONS: Maternal thyroid autoimmunity and transplacental passage of autoantibodies against thyroid antigens may affect the generation or expansion of cells with NK activity and the secretion of inflammatory cytokines. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental and Clinical Endocrinology & Diabetes
volume
119
issue
7
pages
445 - 450
publisher
Georg Thieme Verlag
external identifiers
  • wos:000294649600011
  • pmid:21667438
  • scopus:79960156817
ISSN
1439-3646
DOI
10.1055/s-0031-1279741
language
English
LU publication?
yes
id
b763026b-0daf-4108-8589-090ad243c3d2 (old id 2008168)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21667438?dopt=Abstract
date added to LUP
2011-07-04 14:10:16
date last changed
2017-01-01 04:02:16
@article{b763026b-0daf-4108-8589-090ad243c3d2,
  abstract     = {OBJECTIVE: Several studies indicate that in utero exposure to maternal autoimmune diseases and transplacental passage of autoantibodies affect the risk of autoimmunity in the offspring, e. g., maternally derived GAD65 autoantibody correlates with decreased risk of type 1 diabetes, whereas thyroid peroxidase autoantibody (TPOAb) positivity at birth is associated with increased incidence of autoimmune thyroid disease later in life. The aim of this study was to identify immunological changes in children born to mothers with thyroid autoimmunity that may be related to in utero exposure to autoantibodies. DESIGN AND METHOD: Open label prospective analysis of cord blood lymphocytes and serum cytokines by Flow Cytometry in children born to mothers with autoimmune thyroiditis (AIT) (n=31) and to healthy mothers (n=76) and titers of thyroid autoantibodies were determined in cord blood and in maternal peripheral blood at delivery. RESULTS: We found an increase (almost 30%) in the frequency of cord blood natural killer (NK) cells (p=0.0016) and a minor increase in the subset of T cells expressing NK markers (p=0.028), in children born to AIT mothers. There were no detectable differences in the phenotype or frequency of cord blood memory/activated T cells, including CD4 (+)CD25 (+) T cells, between the 2 groups. The levels of pro-inflammatory cytokines TNF-α, IL-10, IL-12p70, IFN-γ and IL-1β were significantly decreased in offspring of AIT mothers as compared to healthy controls. CONCLUSIONS: Maternal thyroid autoimmunity and transplacental passage of autoantibodies against thyroid antigens may affect the generation or expansion of cells with NK activity and the secretion of inflammatory cytokines.},
  author       = {Svensson, J and Oderup, C and Silver, Christina and Uvebrant, K and Hallengren, Bengt and Ericsson, U B and Arvastsson, Jeanette and Danska, J S and Lantz, Mikael and Cilio, Corrado},
  issn         = {1439-3646},
  language     = {eng},
  number       = {7},
  pages        = {445--450},
  publisher    = {Georg Thieme Verlag},
  series       = {Experimental and Clinical Endocrinology & Diabetes},
  title        = {Maternal Autoimmune Thyroid Disease and the Fetal Immune System.},
  url          = {http://dx.doi.org/10.1055/s-0031-1279741},
  volume       = {119},
  year         = {2011},
}