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The Emerging Role of Calcium-activated Chloride Channel Regulator 1 in Cancer

Hu, Dingyuan LU ; Ansari, Daniel LU ; Bauden, Monika LU orcid ; Zhou, Qimin LU orcid and Andersson, Roland LU (2019) In Anticancer research 39(4). p.1661-1666
Abstract

Calcium-activated chloride channel regulator 1 (CLCA1) belongs to a group of secreted self-cleaving proteins, which activate calcium-dependent chloride channels. CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma. Recently, additional functions of CLCA1 have been unveiled, including its metalloprotease property and involvement in mucus homeostasis and immune modulation. Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer. There is growing interest in utilizing CLCA1 as a diagnostic, prognostic and predictive biomarker, as well as a potential therapeutic target. In this review, the functional role of CLCA1, with... (More)

Calcium-activated chloride channel regulator 1 (CLCA1) belongs to a group of secreted self-cleaving proteins, which activate calcium-dependent chloride channels. CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma. Recently, additional functions of CLCA1 have been unveiled, including its metalloprotease property and involvement in mucus homeostasis and immune modulation. Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer. There is growing interest in utilizing CLCA1 as a diagnostic, prognostic and predictive biomarker, as well as a potential therapeutic target. In this review, the functional role of CLCA1, with a particular focus on cancer, is described.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biomarker, Calcium-activated chloride channel regulator 1, cancer, CLCA1, review
in
Anticancer research
volume
39
issue
4
pages
6 pages
publisher
International Institute of Cancer Research
external identifiers
  • scopus:85064486595
  • pmid:30952704
ISSN
1791-7530
DOI
10.21873/anticanres.13271
language
English
LU publication?
yes
id
20252a84-50ff-480c-8e54-fe0bc07d39f1
date added to LUP
2019-05-03 12:48:34
date last changed
2024-04-02 02:32:53
@article{20252a84-50ff-480c-8e54-fe0bc07d39f1,
  abstract     = {{<p>Calcium-activated chloride channel regulator 1 (CLCA1) belongs to a group of secreted self-cleaving proteins, which activate calcium-dependent chloride channels. CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma. Recently, additional functions of CLCA1 have been unveiled, including its metalloprotease property and involvement in mucus homeostasis and immune modulation. Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer. There is growing interest in utilizing CLCA1 as a diagnostic, prognostic and predictive biomarker, as well as a potential therapeutic target. In this review, the functional role of CLCA1, with a particular focus on cancer, is described.</p>}},
  author       = {{Hu, Dingyuan and Ansari, Daniel and Bauden, Monika and Zhou, Qimin and Andersson, Roland}},
  issn         = {{1791-7530}},
  keywords     = {{biomarker; Calcium-activated chloride channel regulator 1; cancer; CLCA1; review}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1661--1666}},
  publisher    = {{International Institute of Cancer Research}},
  series       = {{Anticancer research}},
  title        = {{The Emerging Role of Calcium-activated Chloride Channel Regulator 1 in Cancer}},
  url          = {{http://dx.doi.org/10.21873/anticanres.13271}},
  doi          = {{10.21873/anticanres.13271}},
  volume       = {{39}},
  year         = {{2019}},
}