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Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis

Wu, Jun John LU ; Ekman, Carl LU ; Jönsen, Andreas LU ; Sturfelt, Gunnar LU ; Bengtsson, Anders LU ; Gottsäter, Anders LU ; Lindblad, Bengt LU ; Lindqvist, Elisabet LU ; Saxne, Tore LU and Dahlbäck, Björn LU (2011) In Arthritis Research and Therapy 13(2).
Abstract
Introduction: Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family. These receptors can be shed from the cell membrane and their soluble extracellular regions can be found in plasma. The objective of this study was to elucidate whether the plasma levels of soluble Mer (sMer) and Tyro3 (sTyro3) were increased in systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), or critical limb ischemia (CLI). Methods: ELISA kits were used to test plasma concentrations in controls and in patients with SLE, RA or CLI. Results: Increased levels of, in particular, sMer and, to some extent, sTyro3, were found in patients with SLE or RA, but not in... (More)
Introduction: Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family. These receptors can be shed from the cell membrane and their soluble extracellular regions can be found in plasma. The objective of this study was to elucidate whether the plasma levels of soluble Mer (sMer) and Tyro3 (sTyro3) were increased in systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), or critical limb ischemia (CLI). Methods: ELISA kits were used to test plasma concentrations in controls and in patients with SLE, RA or CLI. Results: Increased levels of, in particular, sMer and, to some extent, sTyro3, were found in patients with SLE or RA, but not in patients with CLI. Patients with SLE demonstrated the highest sMer levels and there was a strong correlation to higher SLE disease activity score (SLEDAI). In contrast, in patients with RA, the sMer levels did not correlate with the disease activity score (DAS). In SLE, sMer levels were particularly high in those with lupus nephritis, patients who also had decreased C1q levels and increased titers of anti-DNA antibodies. After therapy, the plasma concentrations of sMer decreased in parallel to the decrease in SLEDAI score. Conclusions: The plasma concentrations of sMer and sTyro3 were significantly increased in patients with active SLE and RA, suggesting the TAM receptor shedding was affected by these autoimmune diseases. In particular, sMer was increased in SLE, the plasma levels of sMer reflecting disease activity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis Research and Therapy
volume
13
issue
2
publisher
BioMed Central
external identifiers
  • wos:000292449700027
  • scopus:79955100531
ISSN
1478-6362
DOI
10.1186/ar3316
language
English
LU publication?
yes
id
0057e74a-a7bf-4707-978a-db9614a49008 (old id 2029115)
date added to LUP
2011-08-02 08:56:49
date last changed
2017-08-27 03:39:58
@article{0057e74a-a7bf-4707-978a-db9614a49008,
  abstract     = {Introduction: Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family. These receptors can be shed from the cell membrane and their soluble extracellular regions can be found in plasma. The objective of this study was to elucidate whether the plasma levels of soluble Mer (sMer) and Tyro3 (sTyro3) were increased in systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), or critical limb ischemia (CLI). Methods: ELISA kits were used to test plasma concentrations in controls and in patients with SLE, RA or CLI. Results: Increased levels of, in particular, sMer and, to some extent, sTyro3, were found in patients with SLE or RA, but not in patients with CLI. Patients with SLE demonstrated the highest sMer levels and there was a strong correlation to higher SLE disease activity score (SLEDAI). In contrast, in patients with RA, the sMer levels did not correlate with the disease activity score (DAS). In SLE, sMer levels were particularly high in those with lupus nephritis, patients who also had decreased C1q levels and increased titers of anti-DNA antibodies. After therapy, the plasma concentrations of sMer decreased in parallel to the decrease in SLEDAI score. Conclusions: The plasma concentrations of sMer and sTyro3 were significantly increased in patients with active SLE and RA, suggesting the TAM receptor shedding was affected by these autoimmune diseases. In particular, sMer was increased in SLE, the plasma levels of sMer reflecting disease activity.},
  articleno    = {R62},
  author       = {Wu, Jun John and Ekman, Carl and Jönsen, Andreas and Sturfelt, Gunnar and Bengtsson, Anders and Gottsäter, Anders and Lindblad, Bengt and Lindqvist, Elisabet and Saxne, Tore and Dahlbäck, Björn},
  issn         = {1478-6362},
  language     = {eng},
  number       = {2},
  publisher    = {BioMed Central},
  series       = {Arthritis Research and Therapy},
  title        = {Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis},
  url          = {http://dx.doi.org/10.1186/ar3316},
  volume       = {13},
  year         = {2011},
}