Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study.
(2011) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 159(1). p.209-212- Abstract
- OBJECTIVE: To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. We believe the majority of urgency symptoms in perimenopausal women to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck. If this is the case, there would be no difference in estradiol levels between the groups. STUDY DESIGN: Setting: University hospital. In the observational Women's Health in the Lund Area study, a subset of 400/2221 women reporting urinary incontinence completed a detailed questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone levels measured. Statistical analyses were made by Chi-square test, nonparametrical tests, ANOVA, multi- and univariate... (More)
- OBJECTIVE: To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. We believe the majority of urgency symptoms in perimenopausal women to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck. If this is the case, there would be no difference in estradiol levels between the groups. STUDY DESIGN: Setting: University hospital. In the observational Women's Health in the Lund Area study, a subset of 400/2221 women reporting urinary incontinence completed a detailed questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone levels measured. Statistical analyses were made by Chi-square test, nonparametrical tests, ANOVA, multi- and univariate logistic regression analysis. RESULTS: Stress incontinence was reported by 196, mixed incontinence by 153 and urge incontinence by 43 women; in 369, serumestradiol values were available. Serum estradiol did not differ significantly between stress incontinent (median 49.5pmo/l, range 2.63-875.4), urge incontinent (median 31.6pmol/l, range 2.63-460.7) or mixed incontinent women (median 35.5pmol/l, range 2.63-787.9, p=0.62). Logistic regression analysis correcting for age, parity, hormonal status, smoking, hysterectomy and BMI also failed to show any difference in estradiol levels between the groups (p=0.41-0.58). CONCLUSION: No significant differences in serum estradiol levels between stress, mixed or urge incontinent perimenopausal women could be demonstrated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2058295
- author
- Andrada, Maria LU ; Källén, Karin LU ; Lidfeldt, Jonas LU ; Samsioe, Göran LU and Teleman, Pia LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Mixed urinary incontinence, Female urinary incontinence, Serum, estradiol, Stress urinary incontinence, Urge urinary incontinence
- in
- European Journal of Obstetrics, Gynecology, and Reproductive Biology
- volume
- 159
- issue
- 1
- pages
- 209 - 212
- publisher
- Elsevier
- external identifiers
-
- wos:000298202800042
- pmid:21782314
- scopus:81855161686
- pmid:21782314
- ISSN
- 0301-2115
- DOI
- 10.1016/j.ejogrb.2011.06.022
- language
- English
- LU publication?
- yes
- id
- 06362fbe-1aa8-4fe8-91c3-cf452ca7d4f4 (old id 2058295)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21782314?dopt=Abstract
- date added to LUP
- 2016-04-01 11:02:19
- date last changed
- 2022-01-26 04:53:55
@article{06362fbe-1aa8-4fe8-91c3-cf452ca7d4f4, abstract = {{OBJECTIVE: To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. We believe the majority of urgency symptoms in perimenopausal women to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck. If this is the case, there would be no difference in estradiol levels between the groups. STUDY DESIGN: Setting: University hospital. In the observational Women's Health in the Lund Area study, a subset of 400/2221 women reporting urinary incontinence completed a detailed questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone levels measured. Statistical analyses were made by Chi-square test, nonparametrical tests, ANOVA, multi- and univariate logistic regression analysis. RESULTS: Stress incontinence was reported by 196, mixed incontinence by 153 and urge incontinence by 43 women; in 369, serumestradiol values were available. Serum estradiol did not differ significantly between stress incontinent (median 49.5pmo/l, range 2.63-875.4), urge incontinent (median 31.6pmol/l, range 2.63-460.7) or mixed incontinent women (median 35.5pmol/l, range 2.63-787.9, p=0.62). Logistic regression analysis correcting for age, parity, hormonal status, smoking, hysterectomy and BMI also failed to show any difference in estradiol levels between the groups (p=0.41-0.58). CONCLUSION: No significant differences in serum estradiol levels between stress, mixed or urge incontinent perimenopausal women could be demonstrated.}}, author = {{Andrada, Maria and Källén, Karin and Lidfeldt, Jonas and Samsioe, Göran and Teleman, Pia}}, issn = {{0301-2115}}, keywords = {{Mixed urinary incontinence; Female urinary incontinence; Serum; estradiol; Stress urinary incontinence; Urge urinary incontinence}}, language = {{eng}}, number = {{1}}, pages = {{209--212}}, publisher = {{Elsevier}}, series = {{European Journal of Obstetrics, Gynecology, and Reproductive Biology}}, title = {{Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study.}}, url = {{https://lup.lub.lu.se/search/files/2330938/2255707.pdf}}, doi = {{10.1016/j.ejogrb.2011.06.022}}, volume = {{159}}, year = {{2011}}, }