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Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study.

Andrada, Maria LU ; Källén, Karin LU ; Lidfeldt, Jonas LU ; Samsioe, Göran LU and Teleman, Pia LU (2011) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 159(1). p.209-212
Abstract
OBJECTIVE: To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. We believe the majority of urgency symptoms in perimenopausal women to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck. If this is the case, there would be no difference in estradiol levels between the groups. STUDY DESIGN: Setting: University hospital. In the observational Women's Health in the Lund Area study, a subset of 400/2221 women reporting urinary incontinence completed a detailed questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone levels measured. Statistical analyses were made by Chi-square test, nonparametrical tests, ANOVA, multi- and univariate... (More)
OBJECTIVE: To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. We believe the majority of urgency symptoms in perimenopausal women to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck. If this is the case, there would be no difference in estradiol levels between the groups. STUDY DESIGN: Setting: University hospital. In the observational Women's Health in the Lund Area study, a subset of 400/2221 women reporting urinary incontinence completed a detailed questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone levels measured. Statistical analyses were made by Chi-square test, nonparametrical tests, ANOVA, multi- and univariate logistic regression analysis. RESULTS: Stress incontinence was reported by 196, mixed incontinence by 153 and urge incontinence by 43 women; in 369, serumestradiol values were available. Serum estradiol did not differ significantly between stress incontinent (median 49.5pmo/l, range 2.63-875.4), urge incontinent (median 31.6pmol/l, range 2.63-460.7) or mixed incontinent women (median 35.5pmol/l, range 2.63-787.9, p=0.62). Logistic regression analysis correcting for age, parity, hormonal status, smoking, hysterectomy and BMI also failed to show any difference in estradiol levels between the groups (p=0.41-0.58). CONCLUSION: No significant differences in serum estradiol levels between stress, mixed or urge incontinent perimenopausal women could be demonstrated. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Mixed urinary incontinence, Female urinary incontinence, Serum, estradiol, Stress urinary incontinence, Urge urinary incontinence
in
European Journal of Obstetrics, Gynecology, and Reproductive Biology
volume
159
issue
1
pages
209 - 212
publisher
Elsevier
external identifiers
  • wos:000298202800042
  • pmid:21782314
  • scopus:81855161686
ISSN
0301-2115
DOI
10.1016/j.ejogrb.2011.06.022
language
English
LU publication?
yes
id
06362fbe-1aa8-4fe8-91c3-cf452ca7d4f4 (old id 2058295)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21782314?dopt=Abstract
date added to LUP
2011-08-01 17:31:17
date last changed
2017-08-27 03:40:45
@article{06362fbe-1aa8-4fe8-91c3-cf452ca7d4f4,
  abstract     = {OBJECTIVE: To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. We believe the majority of urgency symptoms in perimenopausal women to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck. If this is the case, there would be no difference in estradiol levels between the groups. STUDY DESIGN: Setting: University hospital. In the observational Women's Health in the Lund Area study, a subset of 400/2221 women reporting urinary incontinence completed a detailed questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone levels measured. Statistical analyses were made by Chi-square test, nonparametrical tests, ANOVA, multi- and univariate logistic regression analysis. RESULTS: Stress incontinence was reported by 196, mixed incontinence by 153 and urge incontinence by 43 women; in 369, serumestradiol values were available. Serum estradiol did not differ significantly between stress incontinent (median 49.5pmo/l, range 2.63-875.4), urge incontinent (median 31.6pmol/l, range 2.63-460.7) or mixed incontinent women (median 35.5pmol/l, range 2.63-787.9, p=0.62). Logistic regression analysis correcting for age, parity, hormonal status, smoking, hysterectomy and BMI also failed to show any difference in estradiol levels between the groups (p=0.41-0.58). CONCLUSION: No significant differences in serum estradiol levels between stress, mixed or urge incontinent perimenopausal women could be demonstrated.},
  author       = {Andrada, Maria and Källén, Karin and Lidfeldt, Jonas and Samsioe, Göran and Teleman, Pia},
  issn         = {0301-2115},
  keyword      = {Mixed urinary incontinence,Female urinary incontinence,Serum,estradiol,Stress urinary incontinence,Urge urinary incontinence},
  language     = {eng},
  number       = {1},
  pages        = {209--212},
  publisher    = {Elsevier},
  series       = {European Journal of Obstetrics, Gynecology, and Reproductive Biology},
  title        = {Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study.},
  url          = {http://dx.doi.org/10.1016/j.ejogrb.2011.06.022},
  volume       = {159},
  year         = {2011},
}