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Stem cell research in stroke: how far from the clinic?

Lindvall, Olle LU and Kokaia, Zaal LU (2011) In Stroke: a journal of cerebral circulation 42(8). p.2369-2375
Abstract
Stem cell-based approaches hold much promise as potential novel treatments to restore function after stroke. Studies in animal models have shown that stem cell transplantation can improve function by replacing neurons or by trophic actions, modulation of inflammation, promotion of angiogenesis, remyelination and axonal plasticity, and neuroprotection. Endogenous neural stem cells are also potential therapeutic targets because they produce new neurons after stroke. Clinical trials are ongoing but there is currently no proven stem cell-based therapy for stroke. Preclinical studies and clinical research will be needed to optimize the therapeutic benefit and minimize the risks of stem cells in stroke.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
transplantation, stroke recovery, stem cells, neuroregeneration, neurogenesis, acute stroke, neural stem cell, inflammation
in
Stroke: a journal of cerebral circulation
volume
42
issue
8
pages
2369 - 2375
publisher
American Heart Association
external identifiers
  • wos:000293077400054
  • pmid:21757669
  • scopus:79961208735
ISSN
1524-4628
DOI
10.1161/STROKEAHA.110.599654
language
English
LU publication?
yes
id
29564348-b086-481f-af9a-aeb66cf36af3 (old id 2058668)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21757669?dopt=Abstract
date added to LUP
2011-08-01 19:52:29
date last changed
2017-11-19 03:43:22
@article{29564348-b086-481f-af9a-aeb66cf36af3,
  abstract     = {Stem cell-based approaches hold much promise as potential novel treatments to restore function after stroke. Studies in animal models have shown that stem cell transplantation can improve function by replacing neurons or by trophic actions, modulation of inflammation, promotion of angiogenesis, remyelination and axonal plasticity, and neuroprotection. Endogenous neural stem cells are also potential therapeutic targets because they produce new neurons after stroke. Clinical trials are ongoing but there is currently no proven stem cell-based therapy for stroke. Preclinical studies and clinical research will be needed to optimize the therapeutic benefit and minimize the risks of stem cells in stroke.},
  author       = {Lindvall, Olle and Kokaia, Zaal},
  issn         = {1524-4628},
  keyword      = {transplantation,stroke recovery,stem cells,neuroregeneration,neurogenesis,acute stroke,neural stem cell,inflammation},
  language     = {eng},
  number       = {8},
  pages        = {2369--2375},
  publisher    = {American Heart Association},
  series       = { Stroke: a journal of cerebral circulation},
  title        = {Stem cell research in stroke: how far from the clinic?},
  url          = {http://dx.doi.org/10.1161/STROKEAHA.110.599654},
  volume       = {42},
  year         = {2011},
}