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Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures

Bengzon, J LU ; Söderström, S ; Kokaia, Z LU orcid ; Kokaia, M LU ; Ernfors, P ; Persson, H ; Ebendal, T and Lindvall, O LU (1992) In Brain Research 587(2). p.42-338
Abstract

Nerve growth factor (NGF) protein levels were determined in various forebrain regions using a two-site immunoassay following kindling-induced seizures. In the dentate gyrus the NGF content was significantly elevated 7 days after the last seizure (to 152% of control). In the piriform and parietal cortices, maximal increases were seen at 12 h (to 261% of control) and at 24 h (to 169% of control), respectively, and the NGF content was then normalized at 7 days. The increased production of NGF might be a protective response or could be involved in plastic changes underlying kindling epileptogenesis.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Cerebral Cortex/anatomy & histology, Kindling, Neurologic/physiology, Male, Nerve Growth Factors/physiology, Prosencephalon/anatomy & histology, Rats, Rats, Inbred Strains, Seizures/metabolism
in
Brain Research
volume
587
issue
2
pages
5 pages
publisher
Elsevier
external identifiers
  • pmid:1525666
  • scopus:0026730721
ISSN
0006-8993
DOI
10.1016/0006-8993(92)91016-8
language
English
LU publication?
no
id
20be847e-de8e-4921-88cd-f292790656b2
date added to LUP
2019-06-25 10:43:58
date last changed
2024-01-01 13:06:49
@article{20be847e-de8e-4921-88cd-f292790656b2,
  abstract     = {{<p>Nerve growth factor (NGF) protein levels were determined in various forebrain regions using a two-site immunoassay following kindling-induced seizures. In the dentate gyrus the NGF content was significantly elevated 7 days after the last seizure (to 152% of control). In the piriform and parietal cortices, maximal increases were seen at 12 h (to 261% of control) and at 24 h (to 169% of control), respectively, and the NGF content was then normalized at 7 days. The increased production of NGF might be a protective response or could be involved in plastic changes underlying kindling epileptogenesis.</p>}},
  author       = {{Bengzon, J and Söderström, S and Kokaia, Z and Kokaia, M and Ernfors, P and Persson, H and Ebendal, T and Lindvall, O}},
  issn         = {{0006-8993}},
  keywords     = {{Animals; Cerebral Cortex/anatomy & histology; Kindling, Neurologic/physiology; Male; Nerve Growth Factors/physiology; Prosencephalon/anatomy & histology; Rats; Rats, Inbred Strains; Seizures/metabolism}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{2}},
  pages        = {{42--338}},
  publisher    = {{Elsevier}},
  series       = {{Brain Research}},
  title        = {{Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures}},
  url          = {{http://dx.doi.org/10.1016/0006-8993(92)91016-8}},
  doi          = {{10.1016/0006-8993(92)91016-8}},
  volume       = {{587}},
  year         = {{1992}},
}