Exercise capacity in relation to body fat distribution and muscle fibre distribution in elderly male subjects with impaired glucose tolerance, type 2 diabetes and matched controls.
Tornberg, Åsa LU
; Elgzyri, Targ
LU
; Eriksson, Karl-Fredrik
LU
; Groop, Leif
LU
; Thorsson, Ola
LU
and Wollmer, Per
LU
(2011)
In Diabetes Research and Clinical Practice
94.
p.57-63
- Abstract
- BACKGROUND: The aim of this study was to examine the impact of insulin sensitivity and muscle fibre composition to exercise capacity in individuals with type 2 diabetes (T2D), impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). METHODS: Thirty-nine male patients with T2D, 44 male subjects with IGT and 58 subjects with NGT matched for age, weight and body mass index (BMI) participated in the study. Insulin sensitivity was obtained with hyperinsulinemic-euglycemic clamps, muscle fibre distribution with a biopsy and exercise capacity from an incremental exercise test. Anthropometric measurements as height, weight, waist and hip circumference were performed. RESULTS: There were small differences between groups in waist hip... (More)
- BACKGROUND: The aim of this study was to examine the impact of insulin sensitivity and muscle fibre composition to exercise capacity in individuals with type 2 diabetes (T2D), impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). METHODS: Thirty-nine male patients with T2D, 44 male subjects with IGT and 58 subjects with NGT matched for age, weight and body mass index (BMI) participated in the study. Insulin sensitivity was obtained with hyperinsulinemic-euglycemic clamps, muscle fibre distribution with a biopsy and exercise capacity from an incremental exercise test. Anthropometric measurements as height, weight, waist and hip circumference were performed. RESULTS: There were small differences between groups in waist hip ratio (WHR) with significance attained between NGT and T2D. There was a progressive reduction in exercise capacity, both expressed as VO(2peak) and work rate from subjects with NGT to IGT to T2D. Multiple regression analysis with VO(2peak) as dependent variable showed insulin sensitivity to be the most important factor followed by Type I fibres. WHR and capillary density also influenced the variance of VO(2peak). CONCLUSION: Exercise capacity is independently related to insulin sensitivity, muscle fibre composition and WHR in subjects with NGT, IGT and T2D who are matched for age and BMI. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2008563
- author
- Tornberg, Åsa
LU
; Elgzyri, Targ
LU
; Eriksson, Karl-Fredrik
LU
; Groop, Leif
LU
; Thorsson, Ola
LU
and Wollmer, Per
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Research and Clinical Practice
- volume
- 94
- pages
- 57 - 63
- publisher
- Elsevier
- external identifiers
-
- wos:000296529100016
- pmid:21636160
- scopus:80054952880
- pmid:21636160
- ISSN
- 1872-8227
- DOI
- 10.1016/j.diabres.2011.05.022
- project
- Fysik aktivitet, träning och kost vid typ 2 diabetes
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Physiotherapy (Closed 2012) (013042000), Unit for Clinical Vascular Disease Research (013242410), Diabetes and Endocrinology (013241530), Clinical Physiology and Nuclear Medicine Unit (013242320)
- id
- 214db6d8-dcb5-465e-ac1d-22c4f756a867 (old id 2008563)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21636160?dopt=Abstract
- date added to LUP
- 2016-04-04 07:50:32
- date last changed
- 2024-05-11 21:24:20
@article{214db6d8-dcb5-465e-ac1d-22c4f756a867,
abstract = {{BACKGROUND: The aim of this study was to examine the impact of insulin sensitivity and muscle fibre composition to exercise capacity in individuals with type 2 diabetes (T2D), impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). METHODS: Thirty-nine male patients with T2D, 44 male subjects with IGT and 58 subjects with NGT matched for age, weight and body mass index (BMI) participated in the study. Insulin sensitivity was obtained with hyperinsulinemic-euglycemic clamps, muscle fibre distribution with a biopsy and exercise capacity from an incremental exercise test. Anthropometric measurements as height, weight, waist and hip circumference were performed. RESULTS: There were small differences between groups in waist hip ratio (WHR) with significance attained between NGT and T2D. There was a progressive reduction in exercise capacity, both expressed as VO(2peak) and work rate from subjects with NGT to IGT to T2D. Multiple regression analysis with VO(2peak) as dependent variable showed insulin sensitivity to be the most important factor followed by Type I fibres. WHR and capillary density also influenced the variance of VO(2peak). CONCLUSION: Exercise capacity is independently related to insulin sensitivity, muscle fibre composition and WHR in subjects with NGT, IGT and T2D who are matched for age and BMI.}},
author = {{Tornberg, Åsa and Elgzyri, Targ and Eriksson, Karl-Fredrik and Groop, Leif and Thorsson, Ola and Wollmer, Per}},
issn = {{1872-8227}},
language = {{eng}},
pages = {{57--63}},
publisher = {{Elsevier}},
series = {{Diabetes Research and Clinical Practice}},
title = {{Exercise capacity in relation to body fat distribution and muscle fibre distribution in elderly male subjects with impaired glucose tolerance, type 2 diabetes and matched controls.}},
url = {{http://dx.doi.org/10.1016/j.diabres.2011.05.022}},
doi = {{10.1016/j.diabres.2011.05.022}},
volume = {{94}},
year = {{2011}},
}