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Low carotid calcium score is associated with higher levels of glycosaminoglycans, tumor necrosis factor-alpha, and parathyroid hormone in human carotid plaques.

Edsfeldt, Andreas LU ; Dias, Nuno LU ; Elmståhl, Barbara LU ; Müller, Markus LU ; Berg, Katarina LU ; Nitulescu, Mihaela LU ; Persson, Ana LU ; Ekberg, Olle LU and Goncalves, Isabel LU (2011) In Stroke; a journal of cerebral circulation 42(10). p.458-2966
Abstract
BACKGROUND AND PURPOSE:



Computed tomography (CT) is used to study coronary artery plaques, but little is known about its potential to characterize plaque composition. This study assesses the relation between carotid calcium score (CCS) by CT and plaque composition, namely extracellular matrix, inflammatory mediators, and calcium metabolites.

METHODS:



Thirty patients with significant carotid stenosis underwent preoperative CT. CCS was quantified by Agaston calcium score. Plaque components were studied histologically and biochemically (collagen, elastin, and glycosaminoglycans). Fraktalkine, interferon-γ, interleukin-10, interleukin-12 p70, interleukin-1β, interleukin-6, monocyte chemoattractant... (More)
BACKGROUND AND PURPOSE:



Computed tomography (CT) is used to study coronary artery plaques, but little is known about its potential to characterize plaque composition. This study assesses the relation between carotid calcium score (CCS) by CT and plaque composition, namely extracellular matrix, inflammatory mediators, and calcium metabolites.

METHODS:



Thirty patients with significant carotid stenosis underwent preoperative CT. CCS was quantified by Agaston calcium score. Plaque components were studied histologically and biochemically (collagen, elastin, and glycosaminoglycans). Fraktalkine, interferon-γ, interleukin-10, interleukin-12 p70, interleukin-1β, interleukin-6, monocyte chemoattractant protein-1, platelet-derived growth factor-AB/BB, RANTES and tumor necrosis factor-α, and parathyroid hormone were measured using Luminex technology.

RESULTS:



Plaques with CCS ≥400 had more calcium (P=0.012), less glycosaminoglycan (P=0.002), tumor necrosis factor-α (P=0.013), and parathyroid hormone (P=0.028) than those with CCS <400. CCS correlated with plaque content of calcium (r=0.62; P<0.001) and inversely with glycosaminoglycan (r=-0.49; P=0.006) and tumor necrosis factor-α (r=-0.56; P=0.001).

CONCLUSIONS:



Human carotid plaques with high CCS are richer in calcium and have lower amounts of glycosaminoglycan, parathyroid hormone, and tumor necrosis factor-α, which is one of the main proinflammatory cytokines involved in atherosclerosis. This suggests that CCS not only reflects the degree of calcification, but also other important biological components relevant for stability such as inflammation. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Stroke; a journal of cerebral circulation
volume
42
issue
10
pages
458 - 2966
publisher
American Heart Association
external identifiers
  • wos:000295217100062
  • pmid:21836100
  • scopus:80053335279
ISSN
1524-4628
DOI
10.1161/STROKEAHA.111.620658
language
English
LU publication?
yes
id
ec8478e8-bc53-42d8-9571-e2cfced3b3a0 (old id 2168560)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21836100?dopt=Abstract
date added to LUP
2011-10-03 13:38:30
date last changed
2017-03-12 03:40:52
@article{ec8478e8-bc53-42d8-9571-e2cfced3b3a0,
  abstract     = {BACKGROUND AND PURPOSE:<br/><br>
<br/><br>
Computed tomography (CT) is used to study coronary artery plaques, but little is known about its potential to characterize plaque composition. This study assesses the relation between carotid calcium score (CCS) by CT and plaque composition, namely extracellular matrix, inflammatory mediators, and calcium metabolites.<br/><br>
METHODS:<br/><br>
<br/><br>
Thirty patients with significant carotid stenosis underwent preoperative CT. CCS was quantified by Agaston calcium score. Plaque components were studied histologically and biochemically (collagen, elastin, and glycosaminoglycans). Fraktalkine, interferon-γ, interleukin-10, interleukin-12 p70, interleukin-1β, interleukin-6, monocyte chemoattractant protein-1, platelet-derived growth factor-AB/BB, RANTES and tumor necrosis factor-α, and parathyroid hormone were measured using Luminex technology.<br/><br>
RESULTS:<br/><br>
<br/><br>
Plaques with CCS ≥400 had more calcium (P=0.012), less glycosaminoglycan (P=0.002), tumor necrosis factor-α (P=0.013), and parathyroid hormone (P=0.028) than those with CCS &lt;400. CCS correlated with plaque content of calcium (r=0.62; P&lt;0.001) and inversely with glycosaminoglycan (r=-0.49; P=0.006) and tumor necrosis factor-α (r=-0.56; P=0.001).<br/><br>
CONCLUSIONS:<br/><br>
<br/><br>
Human carotid plaques with high CCS are richer in calcium and have lower amounts of glycosaminoglycan, parathyroid hormone, and tumor necrosis factor-α, which is one of the main proinflammatory cytokines involved in atherosclerosis. This suggests that CCS not only reflects the degree of calcification, but also other important biological components relevant for stability such as inflammation.},
  author       = {Edsfeldt, Andreas and Dias, Nuno and Elmståhl, Barbara and Müller, Markus and Berg, Katarina and Nitulescu, Mihaela and Persson, Ana and Ekberg, Olle and Goncalves, Isabel},
  issn         = {1524-4628},
  language     = {eng},
  number       = {10},
  pages        = {458--2966},
  publisher    = {American Heart Association},
  series       = {Stroke; a journal of cerebral circulation},
  title        = {Low carotid calcium score is associated with higher levels of glycosaminoglycans, tumor necrosis factor-alpha, and parathyroid hormone in human carotid plaques.},
  url          = {http://dx.doi.org/10.1161/STROKEAHA.111.620658},
  volume       = {42},
  year         = {2011},
}