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A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax

Brodszki, Nicholas LU ; Länsberg, John-Kalle LU ; Dictor, Michael LU ; Gyllstedt, Erik LU ; Ewers, Sven-Börje LU ; Larsson, Marcus LU and Eklund, Erik LU (2011) In Acta Pædiatrica 100(11). p.1448-1453
Abstract
Aim: To expand the treatment options in paediatric Gorham-Stout syndrome (GSS) when conventional therapy is ineffective. Method: Two children with biopsy confirmed GSS, a rare disorder with progressive lymphangiomatosis, were treated with a combination of interferon-alpha-2b, low anticoagulant, low molecular weight heparin, radiotherapy and surgery. Results: The combined therapy resolved the symptoms in the acute phase, and both patients have since been free of symptoms for >2 years. Conclusion: The successful addition of a low anticoagulant, low molecular weight heparin ( tafoxiparin) to the treatment protocol in two paediatric cases of the GSS may justify the use of this approach in similar cases.
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute respiratory failure, Alpha-interferon therapy, Heparin
in
Acta Pædiatrica
volume
100
issue
11
pages
1448 - 1453
publisher
Wiley-Blackwell
external identifiers
  • wos:000296421300020
  • pmid:21605166
  • scopus:80054024069
  • pmid:21605166
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2011.02361.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Paediatrics (Lund) (013002000), Pathology, (Lund) (013030000), Thoracic Surgery (013230027), Oncology, MV (013035000), Matrix biology (013212025)
id
3fcd22ba-682a-45cf-90f7-6718166af96d (old id 2208099)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21605166?dopt=Abstract
date added to LUP
2016-04-01 10:31:00
date last changed
2021-09-22 03:19:04
@article{3fcd22ba-682a-45cf-90f7-6718166af96d,
  abstract     = {Aim: To expand the treatment options in paediatric Gorham-Stout syndrome (GSS) when conventional therapy is ineffective. Method: Two children with biopsy confirmed GSS, a rare disorder with progressive lymphangiomatosis, were treated with a combination of interferon-alpha-2b, low anticoagulant, low molecular weight heparin, radiotherapy and surgery. Results: The combined therapy resolved the symptoms in the acute phase, and both patients have since been free of symptoms for >2 years. Conclusion: The successful addition of a low anticoagulant, low molecular weight heparin ( tafoxiparin) to the treatment protocol in two paediatric cases of the GSS may justify the use of this approach in similar cases.},
  author       = {Brodszki, Nicholas and Länsberg, John-Kalle and Dictor, Michael and Gyllstedt, Erik and Ewers, Sven-Börje and Larsson, Marcus and Eklund, Erik},
  issn         = {1651-2227},
  language     = {eng},
  number       = {11},
  pages        = {1448--1453},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Pædiatrica},
  title        = {A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2011.02361.x},
  doi          = {10.1111/j.1651-2227.2011.02361.x},
  volume       = {100},
  year         = {2011},
}