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HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.

Papadopoulou, Anastasia LU ; Lynch, Kristian LU ; Anderberg, Eva LU ; Landin-Olsson, Mona LU ; Jönsson, Ida LU ; Agardh, Carl-David LU ; Lernmark, Åke LU and Berntorp, Kerstin LU (2012) In Diabetes Research and Clinical Practice 95. p.260-264
Abstract
AIMS: To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM). METHODS: During 2003-2004, women undergoing a 75g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off level defining GDM was a 2-h capillary blood glucose of 7.8mmol/L. 1-2 years after delivery a 75g OGTT was performed, GADA and IA-2A were measured and HLA-DQB1 genes analysed. Data were available for 452 mothers with previous GDM and 168 randomly selected control subjects. RESULTS: HLA-DQB1*0602 was negatively associated with GDM (p=0.033) and with... (More)
AIMS: To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM). METHODS: During 2003-2004, women undergoing a 75g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off level defining GDM was a 2-h capillary blood glucose of 7.8mmol/L. 1-2 years after delivery a 75g OGTT was performed, GADA and IA-2A were measured and HLA-DQB1 genes analysed. Data were available for 452 mothers with previous GDM and 168 randomly selected control subjects. RESULTS: HLA-DQB1*0602 was negatively associated with GDM (p=0.033) and with development of diabetes post partum (p=0.017), whereas high risk HLA were not associated with GDM or with diabetes. The presence of GADA post partum was positively associated with diabetes post partum (p=0.0009), but not with impaired glucose tolerance. CONCLUSIONS: Mothers with GDM and HLA-DQB1*0602 were less likely to develop diabetes after pregnancy, and type 1 diabetes associated high risk HLA genes did not predict type 1 diabetes post partum. Additionally, GADA were positively associated with diabetes development. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Research and Clinical Practice
volume
95
pages
260 - 264
publisher
Elsevier
external identifiers
  • wos:000299953900018
  • pmid:22104260
  • scopus:84856337975
ISSN
1872-8227
DOI
10.1016/j.diabres.2011.10.037
language
English
LU publication?
yes
id
342c1971-f125-40c4-b88b-c47cd4e7b98e (old id 2220566)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22104260?dopt=Abstract
date added to LUP
2011-12-03 09:14:07
date last changed
2017-01-29 04:14:22
@article{342c1971-f125-40c4-b88b-c47cd4e7b98e,
  abstract     = {AIMS: To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM). METHODS: During 2003-2004, women undergoing a 75g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off level defining GDM was a 2-h capillary blood glucose of 7.8mmol/L. 1-2 years after delivery a 75g OGTT was performed, GADA and IA-2A were measured and HLA-DQB1 genes analysed. Data were available for 452 mothers with previous GDM and 168 randomly selected control subjects. RESULTS: HLA-DQB1*0602 was negatively associated with GDM (p=0.033) and with development of diabetes post partum (p=0.017), whereas high risk HLA were not associated with GDM or with diabetes. The presence of GADA post partum was positively associated with diabetes post partum (p=0.0009), but not with impaired glucose tolerance. CONCLUSIONS: Mothers with GDM and HLA-DQB1*0602 were less likely to develop diabetes after pregnancy, and type 1 diabetes associated high risk HLA genes did not predict type 1 diabetes post partum. Additionally, GADA were positively associated with diabetes development.},
  author       = {Papadopoulou, Anastasia and Lynch, Kristian and Anderberg, Eva and Landin-Olsson, Mona and Jönsson, Ida and Agardh, Carl-David and Lernmark, Åke and Berntorp, Kerstin},
  issn         = {1872-8227},
  language     = {eng},
  pages        = {260--264},
  publisher    = {Elsevier},
  series       = {Diabetes Research and Clinical Practice},
  title        = {HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.},
  url          = {http://dx.doi.org/10.1016/j.diabres.2011.10.037},
  volume       = {95},
  year         = {2012},
}