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Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

Chajes, Veronique; Jenab, Mazda; Romieu, Isabelle; Ferrari, Pietro; Dahm, Christina C.; Overvad, Kim; Egeberg, Rikke; Tjonneland, Anne; Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine, et al. (2011) In American Journal of Clinical Nutrition 94(5). p.1304-1313
Abstract
Background: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored. Objective: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST). Design: Fatty acids were measured by gas chromatography in pre-diagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood... (More)
Background: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored. Objective: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST). Design: Fatty acids were measured by gas chromatography in pre-diagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood donation. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks. Results: Positive risk associations for gastric cancer were observed in the highest compared with the lowest quartiles of plasma oleic acid (OR: 1.72; 95% CI: 1.01, 2.94), di-homo-gamma-linolenic acid (OR: 1.92; 95% CI: 1.10, 3.35), alpha-linolenic acid (OR: 3.20; 95% CI: 1.70, 6.06), and the ratio of MUFAs to saturated fatty acids, as an indicator of stearoyl-CoA desaturase-1 enzyme activity (OR: 1.40; 95% CI: 0.81, 2.43). An inverse risk association was observed with the ratio of linoleic to alpha-linolenic acid (OR: 0.37; 95% CI: 0.20, 0.66). Conclusion: These data suggest that a specific prediagnostic plasma phospholipid fatty acid profile, characterized mainly by high concentrations of oleic acid, alpha-linolenic acid, and di-homo-gamma-linolenic acid, which presumably reflect both a complex dietary pattern and altered fatty acid metabolism, may be related to increased gastric cancer risk. Am J Clin Nutr 2011;94:1304-13. (Less)
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American Journal of Clinical Nutrition
volume
94
issue
5
pages
1304 - 1313
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000296236100019
  • scopus:80054887349
ISSN
1938-3207
DOI
10.3945/ajcn.110.005892
language
English
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yes
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4668b7e0-0a65-4a6d-b0d8-6cb0724c97d2 (old id 2253584)
date added to LUP
2012-01-02 08:01:06
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2017-07-23 04:03:27
@article{4668b7e0-0a65-4a6d-b0d8-6cb0724c97d2,
  abstract     = {Background: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored. Objective: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST). Design: Fatty acids were measured by gas chromatography in pre-diagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood donation. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks. Results: Positive risk associations for gastric cancer were observed in the highest compared with the lowest quartiles of plasma oleic acid (OR: 1.72; 95% CI: 1.01, 2.94), di-homo-gamma-linolenic acid (OR: 1.92; 95% CI: 1.10, 3.35), alpha-linolenic acid (OR: 3.20; 95% CI: 1.70, 6.06), and the ratio of MUFAs to saturated fatty acids, as an indicator of stearoyl-CoA desaturase-1 enzyme activity (OR: 1.40; 95% CI: 0.81, 2.43). An inverse risk association was observed with the ratio of linoleic to alpha-linolenic acid (OR: 0.37; 95% CI: 0.20, 0.66). Conclusion: These data suggest that a specific prediagnostic plasma phospholipid fatty acid profile, characterized mainly by high concentrations of oleic acid, alpha-linolenic acid, and di-homo-gamma-linolenic acid, which presumably reflect both a complex dietary pattern and altered fatty acid metabolism, may be related to increased gastric cancer risk. Am J Clin Nutr 2011;94:1304-13.},
  author       = {Chajes, Veronique and Jenab, Mazda and Romieu, Isabelle and Ferrari, Pietro and Dahm, Christina C. and Overvad, Kim and Egeberg, Rikke and Tjonneland, Anne and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Engel, Pierre and Teucher, Birgit and Kaaks, Rudolf and Floegel, Anna and Boeing, Heiner and Trichopoulou, Antonia and Dilis, Vardis and Karapetyan, Tina and Mattiello, Amalia and Tumino, Rosario and Grioni, Sara and Palli, Domenico and Vineis, Paolo and Bueno-de-Mesquita, H. Bas and Numans, Mattijs E. and Peeters, Petra H. M. and Lund, Eiliv and Navarro, Carmen and Ramon Quiros, Jose and Sanchez-Cantalejo, Emilio and Barricarte Gurrea, Aurelio and Dorronsoro, Miren and Regner, Sara and Sonestedt, Emily and Wirfält, Elisabet and Khaw, Kay-Tee and Wareham, Nick and Allen, Naomi E. and Crowe, Francesca L. and Rinaldi, Sabina and Slimani, Nadia and Carneiro, Fatima and Riboli, Elio and Gonzalez, Carlos A.},
  issn         = {1938-3207},
  language     = {eng},
  number       = {5},
  pages        = {1304--1313},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)},
  url          = {http://dx.doi.org/10.3945/ajcn.110.005892},
  volume       = {94},
  year         = {2011},
}