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Late and very late mortality in 5-year survivors of childhood cancer: Changing pattern over four decades. Experience from the Nordic countries.

Garwicz, Stanislaw LU ; Anderson, Harald LU ; Olsen, Jørgen H; Falck Winther, Jeanette; Sankila, Risto; Langmark, Frøydis; Tryggvadóttir, Laufey and Möller, Torgil LU (2012) In International Journal of Cancer 131(7). p.1659-1666
Abstract
Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in five year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is population-based and uses data of the nationwide cancer registries and the cause of death registers. There were in all 37,515 incident cases, diagnosed with cancer before the age of 20 years, between 1960 and 1999. The 5-year survivor cohort used in the mortality analyses consisted of 21,984 patients who were followed-up for vital status until December 31, 2005 (Norway, Sweden) or 2006 (Denmark, Finland, Iceland). At the... (More)
Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in five year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is population-based and uses data of the nationwide cancer registries and the cause of death registers. There were in all 37,515 incident cases, diagnosed with cancer before the age of 20 years, between 1960 and 1999. The 5-year survivor cohort used in the mortality analyses consisted of 21,984 patients who were followed-up for vital status until December 31, 2005 (Norway, Sweden) or 2006 (Denmark, Finland, Iceland). At the latest follow-up, 2,324 patients were dead. The overall standardized mortality ratio was 8.3 and the absolute excess risk was 6.2 per 1,000 person-years. The pattern of causes of death varied markedly between different groups of primary cancer diagnosis, and was highly dependent on time passed since diagnosis. With shorter follow-up the mortality was mainly due to primary cancer, while with longer follow-up, mortality due to second cancer and non-cancer causes became more prominent. Mortality between 5 and 10 years after diagnosis continued to decrease in patients treated during the most recent period of time, 1990-99, compared to previous periods, while mortality after 10 years changed very little with time period. We conclude that improvement of definite survival demands not only reducing early but also late and very late mortality. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
late mortality, childhood cancer, very late mortality, 5-year survivors, long-term follow-up
in
International Journal of Cancer
volume
131
issue
7
pages
1659 - 1666
publisher
John Wiley & Sons
external identifiers
  • wos:000306915700033
  • pmid:22170520
  • scopus:84864432282
ISSN
0020-7136
DOI
10.1002/ijc.27393
language
English
LU publication?
yes
id
49e8a4b9-b334-4733-8a22-c1017a69fb3e (old id 2274029)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22170520?dopt=Abstract
date added to LUP
2012-01-03 19:39:58
date last changed
2017-09-10 03:15:35
@article{49e8a4b9-b334-4733-8a22-c1017a69fb3e,
  abstract     = {Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in five year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is population-based and uses data of the nationwide cancer registries and the cause of death registers. There were in all 37,515 incident cases, diagnosed with cancer before the age of 20 years, between 1960 and 1999. The 5-year survivor cohort used in the mortality analyses consisted of 21,984 patients who were followed-up for vital status until December 31, 2005 (Norway, Sweden) or 2006 (Denmark, Finland, Iceland). At the latest follow-up, 2,324 patients were dead. The overall standardized mortality ratio was 8.3 and the absolute excess risk was 6.2 per 1,000 person-years. The pattern of causes of death varied markedly between different groups of primary cancer diagnosis, and was highly dependent on time passed since diagnosis. With shorter follow-up the mortality was mainly due to primary cancer, while with longer follow-up, mortality due to second cancer and non-cancer causes became more prominent. Mortality between 5 and 10 years after diagnosis continued to decrease in patients treated during the most recent period of time, 1990-99, compared to previous periods, while mortality after 10 years changed very little with time period. We conclude that improvement of definite survival demands not only reducing early but also late and very late mortality.},
  author       = {Garwicz, Stanislaw and Anderson, Harald and Olsen, Jørgen H and Falck Winther, Jeanette and Sankila, Risto and Langmark, Frøydis and Tryggvadóttir, Laufey and Möller, Torgil},
  issn         = {0020-7136},
  keyword      = {late mortality,childhood cancer,very late mortality,5-year survivors,long-term follow-up},
  language     = {eng},
  number       = {7},
  pages        = {1659--1666},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Late and very late mortality in 5-year survivors of childhood cancer: Changing pattern over four decades. Experience from the Nordic countries.},
  url          = {http://dx.doi.org/10.1002/ijc.27393},
  volume       = {131},
  year         = {2012},
}