The androgen receptor and stem cell pathways in prostate and bladder cancers (Review)
(2012) In International Journal of Oncology 40(1). p.5-12- Abstract
- Bladder cancer is three times more common in men than in women. However, the physiological basis of the male predominance of bladder cancer remains poorly understood. A higher than expected association of prostate and bladder cancers has also been reported which may indicate a common mechanism of carcinogenesis. Consistent with this, androgens and the androgen receptor (AR) play essential roles in prostate carcinogenesis and are believed to play a role in bladder carcinogenesis. There is also evidence implicating cancer stem cells in prostate and bladder cancers. Indeed putative prostate and bladder cancer stem cells share some common molecular features. We highlight key proteins (CD49f, CD133, PTEN, CD44) which are implicated in both... (More)
- Bladder cancer is three times more common in men than in women. However, the physiological basis of the male predominance of bladder cancer remains poorly understood. A higher than expected association of prostate and bladder cancers has also been reported which may indicate a common mechanism of carcinogenesis. Consistent with this, androgens and the androgen receptor (AR) play essential roles in prostate carcinogenesis and are believed to play a role in bladder carcinogenesis. There is also evidence implicating cancer stem cells in prostate and bladder cancers. Indeed putative prostate and bladder cancer stem cells share some common molecular features. We highlight key proteins (CD49f, CD133, PTEN, CD44) which are implicated in both prostate and bladder cancers and are enriched in putative prostate and bladder cancer stem cells. We examine published chromatin immuno-precipitation studies analyzing the genome-wide distribution of the AR to identify AR association with, and by inference potential AR-regulation of, these loci. We discuss recent evidence indicating a role for the AR in the splicing of the key urological stem cell protein CD44. We propose a model whereby aberrant AR regulation of these putative stem cell proteins contributes to malignant transformation of prostate and bladder cells. For these reasons we propose that the relationship between androgens and cancer stem cell associated proteins warrants further investigation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2279010
- author
- Marcinkiewicz, Katarzyna ; Scotland, Kymora B. ; Boorjian, Stephen A. ; Nilsson, Emeli LU ; Persson, Jenny L LU ; Abrahamsson, Per-Anders LU ; Allegrucci, Cinzia ; Hughes, Ieuan A. ; Gudas, Lorraine J. and Mongan, Nigel P.
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- androgen receptor, cancer stem cell, chromatin immunoprecipitation, CD44, CD133/prominin 1, CD49f/ITGA6, PTEN, prostate, bladder
- in
- International Journal of Oncology
- volume
- 40
- issue
- 1
- pages
- 5 - 12
- publisher
- Spandidos Publications
- external identifiers
-
- wos:000297403800001
- scopus:84455171453
- pmid:21956088
- ISSN
- 1019-6439
- DOI
- 10.3892/ijo.2011.1212
- language
- English
- LU publication?
- yes
- additional info
- Department affilation moved from v1000588 (Tumour Biology, Malmö) to v1000562 (Department of Translational Medicine) on 2016-01-18 14:39:30.
- id
- 6db8f71c-25ac-404d-bd90-ea139d1a22bb (old id 2279010)
- date added to LUP
- 2016-04-01 13:28:18
- date last changed
- 2022-03-14 00:14:00
@article{6db8f71c-25ac-404d-bd90-ea139d1a22bb, abstract = {{Bladder cancer is three times more common in men than in women. However, the physiological basis of the male predominance of bladder cancer remains poorly understood. A higher than expected association of prostate and bladder cancers has also been reported which may indicate a common mechanism of carcinogenesis. Consistent with this, androgens and the androgen receptor (AR) play essential roles in prostate carcinogenesis and are believed to play a role in bladder carcinogenesis. There is also evidence implicating cancer stem cells in prostate and bladder cancers. Indeed putative prostate and bladder cancer stem cells share some common molecular features. We highlight key proteins (CD49f, CD133, PTEN, CD44) which are implicated in both prostate and bladder cancers and are enriched in putative prostate and bladder cancer stem cells. We examine published chromatin immuno-precipitation studies analyzing the genome-wide distribution of the AR to identify AR association with, and by inference potential AR-regulation of, these loci. We discuss recent evidence indicating a role for the AR in the splicing of the key urological stem cell protein CD44. We propose a model whereby aberrant AR regulation of these putative stem cell proteins contributes to malignant transformation of prostate and bladder cells. For these reasons we propose that the relationship between androgens and cancer stem cell associated proteins warrants further investigation.}}, author = {{Marcinkiewicz, Katarzyna and Scotland, Kymora B. and Boorjian, Stephen A. and Nilsson, Emeli and Persson, Jenny L and Abrahamsson, Per-Anders and Allegrucci, Cinzia and Hughes, Ieuan A. and Gudas, Lorraine J. and Mongan, Nigel P.}}, issn = {{1019-6439}}, keywords = {{androgen receptor; cancer stem cell; chromatin immunoprecipitation; CD44; CD133/prominin 1; CD49f/ITGA6; PTEN; prostate; bladder}}, language = {{eng}}, number = {{1}}, pages = {{5--12}}, publisher = {{Spandidos Publications}}, series = {{International Journal of Oncology}}, title = {{The androgen receptor and stem cell pathways in prostate and bladder cancers (Review)}}, url = {{http://dx.doi.org/10.3892/ijo.2011.1212}}, doi = {{10.3892/ijo.2011.1212}}, volume = {{40}}, year = {{2012}}, }