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The androgen receptor and stem cell pathways in prostate and bladder cancers (Review)

Marcinkiewicz, Katarzyna; Scotland, Kymora B.; Boorjian, Stephen A.; Nilsson, Emeli LU ; Persson, Jenny L LU ; Abrahamsson, Per-Anders LU ; Allegrucci, Cinzia; Hughes, Ieuan A.; Gudas, Lorraine J. and Mongan, Nigel P. (2012) In International Journal of Oncology 40(1). p.5-12
Abstract
Bladder cancer is three times more common in men than in women. However, the physiological basis of the male predominance of bladder cancer remains poorly understood. A higher than expected association of prostate and bladder cancers has also been reported which may indicate a common mechanism of carcinogenesis. Consistent with this, androgens and the androgen receptor (AR) play essential roles in prostate carcinogenesis and are believed to play a role in bladder carcinogenesis. There is also evidence implicating cancer stem cells in prostate and bladder cancers. Indeed putative prostate and bladder cancer stem cells share some common molecular features. We highlight key proteins (CD49f, CD133, PTEN, CD44) which are implicated in both... (More)
Bladder cancer is three times more common in men than in women. However, the physiological basis of the male predominance of bladder cancer remains poorly understood. A higher than expected association of prostate and bladder cancers has also been reported which may indicate a common mechanism of carcinogenesis. Consistent with this, androgens and the androgen receptor (AR) play essential roles in prostate carcinogenesis and are believed to play a role in bladder carcinogenesis. There is also evidence implicating cancer stem cells in prostate and bladder cancers. Indeed putative prostate and bladder cancer stem cells share some common molecular features. We highlight key proteins (CD49f, CD133, PTEN, CD44) which are implicated in both prostate and bladder cancers and are enriched in putative prostate and bladder cancer stem cells. We examine published chromatin immuno-precipitation studies analyzing the genome-wide distribution of the AR to identify AR association with, and by inference potential AR-regulation of, these loci. We discuss recent evidence indicating a role for the AR in the splicing of the key urological stem cell protein CD44. We propose a model whereby aberrant AR regulation of these putative stem cell proteins contributes to malignant transformation of prostate and bladder cells. For these reasons we propose that the relationship between androgens and cancer stem cell associated proteins warrants further investigation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
androgen receptor, cancer stem cell, chromatin immunoprecipitation, CD44, CD133/prominin 1, CD49f/ITGA6, PTEN, prostate, bladder
in
International Journal of Oncology
volume
40
issue
1
pages
5 - 12
publisher
D.A. Spandidos
external identifiers
  • wos:000297403800001
  • scopus:84455171453
ISSN
1019-6439
DOI
10.3892/ijo.2011.1212
language
English
LU publication?
yes
id
6db8f71c-25ac-404d-bd90-ea139d1a22bb (old id 2279010)
date added to LUP
2012-01-11 13:59:09
date last changed
2017-10-22 04:06:42
@article{6db8f71c-25ac-404d-bd90-ea139d1a22bb,
  abstract     = {Bladder cancer is three times more common in men than in women. However, the physiological basis of the male predominance of bladder cancer remains poorly understood. A higher than expected association of prostate and bladder cancers has also been reported which may indicate a common mechanism of carcinogenesis. Consistent with this, androgens and the androgen receptor (AR) play essential roles in prostate carcinogenesis and are believed to play a role in bladder carcinogenesis. There is also evidence implicating cancer stem cells in prostate and bladder cancers. Indeed putative prostate and bladder cancer stem cells share some common molecular features. We highlight key proteins (CD49f, CD133, PTEN, CD44) which are implicated in both prostate and bladder cancers and are enriched in putative prostate and bladder cancer stem cells. We examine published chromatin immuno-precipitation studies analyzing the genome-wide distribution of the AR to identify AR association with, and by inference potential AR-regulation of, these loci. We discuss recent evidence indicating a role for the AR in the splicing of the key urological stem cell protein CD44. We propose a model whereby aberrant AR regulation of these putative stem cell proteins contributes to malignant transformation of prostate and bladder cells. For these reasons we propose that the relationship between androgens and cancer stem cell associated proteins warrants further investigation.},
  author       = {Marcinkiewicz, Katarzyna and Scotland, Kymora B. and Boorjian, Stephen A. and Nilsson, Emeli and Persson, Jenny L and Abrahamsson, Per-Anders and Allegrucci, Cinzia and Hughes, Ieuan A. and Gudas, Lorraine J. and Mongan, Nigel P.},
  issn         = {1019-6439},
  keyword      = {androgen receptor,cancer stem cell,chromatin immunoprecipitation,CD44,CD133/prominin 1,CD49f/ITGA6,PTEN,prostate,bladder},
  language     = {eng},
  number       = {1},
  pages        = {5--12},
  publisher    = {D.A. Spandidos},
  series       = {International Journal of Oncology},
  title        = {The androgen receptor and stem cell pathways in prostate and bladder cancers (Review)},
  url          = {http://dx.doi.org/10.3892/ijo.2011.1212},
  volume       = {40},
  year         = {2012},
}