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Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

Tobias, Deirdre K ; Merino, Jordi LU ; Ahmad, Abrar LU ; Aiken, Catherine ; Benham, Jamie L ; Bodhini, Dhanasekaran ; Clark, Amy L ; Colclough, Kevin ; Corcoy, Rosa and Cromer, Sara J , et al. (2023) In Nature Medicine 29(10). p.2438-2457
Abstract

Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis,... (More)

Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Medical research, Translational research
in
Nature Medicine
volume
29
issue
10
pages
20 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85173437266
  • pmid:37794253
ISSN
1546-170X
DOI
10.1038/s41591-023-02502-5
language
English
LU publication?
yes
additional info
© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
id
235327ae-c81a-40b8-ba8e-bdca027fb053
date added to LUP
2023-10-20 09:07:34
date last changed
2024-04-19 03:40:10
@article{235327ae-c81a-40b8-ba8e-bdca027fb053,
  abstract     = {{<p>Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.</p>}},
  author       = {{Tobias, Deirdre K and Merino, Jordi and Ahmad, Abrar and Aiken, Catherine and Benham, Jamie L and Bodhini, Dhanasekaran and Clark, Amy L and Colclough, Kevin and Corcoy, Rosa and Cromer, Sara J and Duan, Daisy and Felton, Jamie L and Francis, Ellen C and Gillard, Pieter and Gingras, Véronique and Gaillard, Romy and Haider, Eram and Hughes, Alice and Ikle, Jennifer M and Jacobsen, Laura M and Kahkoska, Anna R and Kettunen, Jarno L T and Kreienkamp, Raymond J and Lim, Lee-Ling and Männistö, Jonna M E and Massey, Robert and Mclennan, Niamh-Maire and Miller, Rachel G and Morieri, Mario Luca and Most, Jasper and Naylor, Rochelle N and Ozkan, Bige and Patel, Kashyap Amratlal and Pilla, Scott J and Prystupa, Katsiaryna and Raghavan, Sridharan and Rooney, Mary R and Schön, Martin and Semnani-Azad, Zhila and Sevilla-Gonzalez, Magdalena and Svalastoga, Pernille and Takele, Wubet Worku and Tam, Claudia Ha-Ting and Thuesen, Anne Cathrine B and Tosur, Mustafa and Wallace, Amelia S and Wang, Caroline C and Wong, Jessie J and Yamamoto, Jennifer M and Young, Katherine and Amouyal, Chloé and Andersen, Mette K and Bonham, Maxine P and Chen, Mingling and Cheng, Feifei and Chikowore, Tinashe and Chivers, Sian C and Clemmensen, Christoffer and Dabelea, Dana and Dawed, Adem Y and Deutsch, Aaron J and Dickens, Laura T and DiMeglio, Linda A and Dudenhöffer-Pfeifer, Monika and Evans-Molina, Carmella and Fernández-Balsells, María Mercè and Fitipaldi, Hugo and Fitzpatrick, Stephanie L and Gitelman, Stephen E and Goodarzi, Mark O and Grieger, Jessica A and Guasch-Ferré, Marta and Habibi, Nahal and Hansen, Torben and Huang, Chuiguo and Harris-Kawano, Arianna and Ismail, Heba M and Hoag, Benjamin and Johnson, Randi K and Jones, Angus G and Koivula, Robert W and Leong, Aaron and Leung, Gloria K W and Libman, Ingrid M and Liu, Kai and Long, S Alice and Lowe, William L and Morton, Robert W and Motala, Ayesha A and Onengut-Gumuscu, Suna and Pankow, James S and Pathirana, Maleesa and Pazmino, Sofia and Perez, Dianna and Petrie, John R and Powe, Camille E and Quinteros, Alejandra and Jain, Rashmi and Ray, Debashree and Ried-Larsen, Mathias and Saeed, Zeb and Santhakumar, Vanessa and Kanbour, Sarah and Sarkar, Sudipa and Monaco, Gabriela S F and Scholtens, Denise M and Selvin, Elizabeth and Sheu, Wayne Huey-Herng and Speake, Cate and Stanislawski, Maggie A and Steenackers, Nele and Steck, Andrea K and Stefan, Norbert and Støy, Julie and Taylor, Rachael and Tye, Sok Cin and Ukke, Gebresilasea Gendisha and Urazbayeva, Marzhan and Van der Schueren, Bart and Vatier, Camille and Wentworth, John M and Hannah, Wesley and White, Sara L and Yu, Gechang and Zhang, Yingchai and Zhou, Shao J and Beltrand, Jacques and Polak, Michel and Aukrust, Ingvild and de Franco, Elisa and Flanagan, Sarah E and Maloney, Kristin A and McGovern, Andrew and Molnes, Janne and Nakabuye, Mariam and Njølstad, Pål Rasmus and Pomares-Millan, Hugo and Provenzano, Michele and Saint-Martin, Cécile and Zhang, Cuilin and Zhu, Yeyi and Auh, Sungyoung and de Souza, Russell and Fawcett, Andrea J and Gruber, Chandra and Mekonnen, Eskedar Getie and Mixter, Emily and Sherifali, Diana and Eckel, Robert H and Nolan, John J and Philipson, Louis H and Brown, Rebecca J and Billings, Liana K and Boyle, Kristen and Costacou, Tina and Dennis, John M and Florez, Jose C and Gloyn, Anna L and Gomez, Maria F and Gottlieb, Peter A and Greeley, Siri Atma W and Griffin, Kurt and Hattersley, Andrew T and Hirsch, Irl B and Hivert, Marie-France and Hood, Korey K and Josefson, Jami L and Kwak, Soo Heon and Laffel, Lori M and Lim, Siew S and Loos, Ruth J F and Ma, Ronald C W and Mathieu, Chantal and Mathioudakis, Nestoras and Meigs, James B and Misra, Shivani and Mohan, Viswanathan and Murphy, Rinki and Oram, Richard and Owen, Katharine R and Ozanne, Susan E and Pearson, Ewan R and Perng, Wei and Pollin, Toni I and Pop-Busui, Rodica and Pratley, Richard E and Redman, Leanne M and Redondo, Maria J and Reynolds, Rebecca M and Semple, Robert K and Sherr, Jennifer L and Sims, Emily K and Sweeting, Arianne and Tuomi, Tiinamaija and Udler, Miriam S and Vesco, Kimberly K and Vilsbøll, Tina and Wagner, Robert and Rich, Stephen S and Franks, Paul W}},
  issn         = {{1546-170X}},
  keywords     = {{Medical research; Translational research}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{2438--2457}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Medicine}},
  title        = {{Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine}},
  url          = {{http://dx.doi.org/10.1038/s41591-023-02502-5}},
  doi          = {{10.1038/s41591-023-02502-5}},
  volume       = {{29}},
  year         = {{2023}},
}