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Quality of life as a predictor for survival in patients with small intestinal neuroendocrine tumours

Ohlsson, Håkan LU orcid ; Nilsson, Martin LU orcid ; Sundlöv, Anna LU orcid ; Malmström, Marlene LU orcid and Almquist, Martin LU (2025) In Journal of Neuroendocrinology 37(11).
Abstract

Health-related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survival in patients with siNET. We included 85 patients with advanced siNET who completed the validated HRQoL instruments, EORTC QLQ-C30 and GI.NET21. We used Cox proportional hazards to calculate the hazard ratio (HR) of survival according to the QLQ-C30 summary score, adjusting for clinical variables selected with causal inference. Flexible parametric modelling using cubic splines was used to illustrate the time-dependent relationship between HRQoL and OS. The QLQ-C30 summary score was correlated with... (More)

Health-related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survival in patients with siNET. We included 85 patients with advanced siNET who completed the validated HRQoL instruments, EORTC QLQ-C30 and GI.NET21. We used Cox proportional hazards to calculate the hazard ratio (HR) of survival according to the QLQ-C30 summary score, adjusting for clinical variables selected with causal inference. Flexible parametric modelling using cubic splines was used to illustrate the time-dependent relationship between HRQoL and OS. The QLQ-C30 summary score was correlated with overall survival (OS) with an adjusted HR of 0.62 (95% CI 0.46–0.83, p <.001) for each 10-point increase in summary score. Compared to a model using only clinical variables, the summary score increased predictive accuracy by eight percentage units and improved model fit. The inclusion of GI.NET21 with the summary score yielded similar results. HRQoL predicts overall survival in patients with siNET, providing additional information to clinical variables. Measuring HRQoL might be useful when following patients with siNET.

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Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
NET, small intestine, survival HRQoL
in
Journal of Neuroendocrinology
volume
37
issue
11
article number
e70081
publisher
Wiley-Blackwell
external identifiers
  • scopus:105013025801
  • pmid:40796203
ISSN
0953-8194
DOI
10.1111/jne.70081
language
English
LU publication?
yes
id
2359f786-726a-4301-aa8c-f9e56b3d1d40
date added to LUP
2026-01-08 10:01:41
date last changed
2026-01-09 03:19:44
@article{2359f786-726a-4301-aa8c-f9e56b3d1d40,
  abstract     = {{<p>Health-related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survival in patients with siNET. We included 85 patients with advanced siNET who completed the validated HRQoL instruments, EORTC QLQ-C30 and GI.NET21. We used Cox proportional hazards to calculate the hazard ratio (HR) of survival according to the QLQ-C30 summary score, adjusting for clinical variables selected with causal inference. Flexible parametric modelling using cubic splines was used to illustrate the time-dependent relationship between HRQoL and OS. The QLQ-C30 summary score was correlated with overall survival (OS) with an adjusted HR of 0.62 (95% CI 0.46–0.83, p &lt;.001) for each 10-point increase in summary score. Compared to a model using only clinical variables, the summary score increased predictive accuracy by eight percentage units and improved model fit. The inclusion of GI.NET21 with the summary score yielded similar results. HRQoL predicts overall survival in patients with siNET, providing additional information to clinical variables. Measuring HRQoL might be useful when following patients with siNET.</p>}},
  author       = {{Ohlsson, Håkan and Nilsson, Martin and Sundlöv, Anna and Malmström, Marlene and Almquist, Martin}},
  issn         = {{0953-8194}},
  keywords     = {{NET; small intestine; survival HRQoL}},
  language     = {{eng}},
  number       = {{11}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Neuroendocrinology}},
  title        = {{Quality of life as a predictor for survival in patients with small intestinal neuroendocrine tumours}},
  url          = {{http://dx.doi.org/10.1111/jne.70081}},
  doi          = {{10.1111/jne.70081}},
  volume       = {{37}},
  year         = {{2025}},
}