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Second malignant neoplasms in digestive organs after childhood cancer: a cohort-nested case-control study

Tukenova, Markhaba; Diallo, Ibrahima; Anderson, Harald LU ; Hawkins, Mike; Garwicz, Stanislaw LU ; Sankila, Risto; El Fayech, Chiraz; Winter, Dave; Rubino, Carole and Adjadj, Elisabeth, et al. (2012) In International Journal of Radiation Oncology, Biology, Physics 82(3). p.383-390
Abstract
Purpose: Cancers of the digestive system constitute a major risk for childhood cancer survivors treated with radiotherapy once they reach adulthood. The aim of this study was to determine therapy-related risk factors for the development of a second malignancy in the digestive organs (SMDO) after a childhood cancer. Methods and Materials: Among 4,568 2-year survivors of a childhood solid cancer diagnosed before 17 years of age at eight French and British centers, and among 25,120 patients diagnosed as having a malignant neoplasm before the age of 20 years, whose data were extracted from the Nordic Cancer Registries, we matched 58 case patients (41 men and 17 women) of SMDO and 167 controls, in their respective cohort, for sex, age at first... (More)
Purpose: Cancers of the digestive system constitute a major risk for childhood cancer survivors treated with radiotherapy once they reach adulthood. The aim of this study was to determine therapy-related risk factors for the development of a second malignancy in the digestive organs (SMDO) after a childhood cancer. Methods and Materials: Among 4,568 2-year survivors of a childhood solid cancer diagnosed before 17 years of age at eight French and British centers, and among 25,120 patients diagnosed as having a malignant neoplasm before the age of 20 years, whose data were extracted from the Nordic Cancer Registries, we matched 58 case patients (41 men and 17 women) of SMDO and 167 controls, in their respective cohort, for sex, age at first cancer, calendar year of occurrence of the first cancer, and duration of follow-up. The radiation dose received at the site of each second malignancy and at the corresponding site of its matched control was estimated. Results: The risk of developing a SMDO was 9.7-fold higher in relation to the general populations in France and the United Kingdom. In the case-control study, a strong dose-response relationship was estimated, compared with that in survivors who had not received radiotherapy; the odds ratio was 5.2 (95% CI, 1.7-16.0) for local radiation doses between 10 and 29 Gy and 9.6 (95% CI, 2.6-35.2) for doses equal to or greater than 30 Gy. Chemotherapy was also found to increase the risk of developing SMDO. Conclusions: This study confirms that childhood cancer treatments strongly increase the risk of SMDO, which occur only after a very long latency period. (C) 2012 Elsevier Inc. (Less)
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published
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keywords
Childhood cancer, Second malignancy in digestive tract, Radiotherapy, Chemotherapy
in
International Journal of Radiation Oncology, Biology, Physics
volume
82
issue
3
pages
383 - 390
publisher
Elsevier
external identifiers
  • wos:000300423500007
  • scopus:84856407464
ISSN
0360-3016
DOI
10.1016/j.ijrobp.2011.05.069
language
English
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yes
id
f12a773f-7f3f-45e8-adfa-9c0dd2fd88a6 (old id 2390744)
date added to LUP
2012-04-02 09:24:38
date last changed
2017-10-29 03:12:49
@article{f12a773f-7f3f-45e8-adfa-9c0dd2fd88a6,
  abstract     = {Purpose: Cancers of the digestive system constitute a major risk for childhood cancer survivors treated with radiotherapy once they reach adulthood. The aim of this study was to determine therapy-related risk factors for the development of a second malignancy in the digestive organs (SMDO) after a childhood cancer. Methods and Materials: Among 4,568 2-year survivors of a childhood solid cancer diagnosed before 17 years of age at eight French and British centers, and among 25,120 patients diagnosed as having a malignant neoplasm before the age of 20 years, whose data were extracted from the Nordic Cancer Registries, we matched 58 case patients (41 men and 17 women) of SMDO and 167 controls, in their respective cohort, for sex, age at first cancer, calendar year of occurrence of the first cancer, and duration of follow-up. The radiation dose received at the site of each second malignancy and at the corresponding site of its matched control was estimated. Results: The risk of developing a SMDO was 9.7-fold higher in relation to the general populations in France and the United Kingdom. In the case-control study, a strong dose-response relationship was estimated, compared with that in survivors who had not received radiotherapy; the odds ratio was 5.2 (95% CI, 1.7-16.0) for local radiation doses between 10 and 29 Gy and 9.6 (95% CI, 2.6-35.2) for doses equal to or greater than 30 Gy. Chemotherapy was also found to increase the risk of developing SMDO. Conclusions: This study confirms that childhood cancer treatments strongly increase the risk of SMDO, which occur only after a very long latency period. (C) 2012 Elsevier Inc.},
  author       = {Tukenova, Markhaba and Diallo, Ibrahima and Anderson, Harald and Hawkins, Mike and Garwicz, Stanislaw and Sankila, Risto and El Fayech, Chiraz and Winter, Dave and Rubino, Carole and Adjadj, Elisabeth and Haddy, Nadia and Oberlin, Odile and Möller, Torgil and Langmark, Froydis and Tryggvadottir, Laufey and Pacquement, Helene and Svahn-Tapper, Gudrun and de Vathaire, Florent},
  issn         = {0360-3016},
  keyword      = {Childhood cancer,Second malignancy in digestive tract,Radiotherapy,Chemotherapy},
  language     = {eng},
  number       = {3},
  pages        = {383--390},
  publisher    = {Elsevier},
  series       = {International Journal of Radiation Oncology, Biology, Physics},
  title        = {Second malignant neoplasms in digestive organs after childhood cancer: a cohort-nested case-control study},
  url          = {http://dx.doi.org/10.1016/j.ijrobp.2011.05.069},
  volume       = {82},
  year         = {2012},
}