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Multinodal high throughput acoustic trapping of exosomes from urine samples

Broman, Axel LU ; Lenshof, Andreas LU ; Evander, Mikael LU ; Ku, Anson LU ; Ceder, Yvonne LU orcid and Laurell, Thomas LU (2019) 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 p.2-3
Abstract

We report a new design of an acoustophoretic trapping device with greatly increased capacity and throughput, compared to current commercial systems. Acoustic trapping enables nanoparticle and exosome enrichment without the need for ultracentrifugation. The commercial acoustic trapping technology, AcouTrap (AcouSort AB), typically operates at flow rates < 50 μl/min which limits processing of larger samples. Using a larger capillary that supports an acoustic multi-node resonance, capacity and throughput was increased a factor 40 compared to AcouTrap. It was possible to capture and enrich exosomes from urine samples at 30 times higher flow rate than previously reported.

Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acoustic trapping, Acoustophoresis, Exosomes, High throughput
host publication
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
series title
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
pages
2 pages
publisher
Chemical and Biological Microsystems Society
conference name
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
conference location
Basel, Switzerland
conference dates
2019-10-27 - 2019-10-31
external identifiers
  • scopus:85094943795
ISBN
9781733419000
language
English
LU publication?
yes
id
23b79b6f-0fe6-4e5e-92cd-304ceb6b2941
date added to LUP
2020-11-24 07:57:14
date last changed
2023-10-22 20:48:38
@inproceedings{23b79b6f-0fe6-4e5e-92cd-304ceb6b2941,
  abstract     = {{<p>We report a new design of an acoustophoretic trapping device with greatly increased capacity and throughput, compared to current commercial systems. Acoustic trapping enables nanoparticle and exosome enrichment without the need for ultracentrifugation. The commercial acoustic trapping technology, AcouTrap (AcouSort AB), typically operates at flow rates &lt; 50 μl/min which limits processing of larger samples. Using a larger capillary that supports an acoustic multi-node resonance, capacity and throughput was increased a factor 40 compared to AcouTrap. It was possible to capture and enrich exosomes from urine samples at 30 times higher flow rate than previously reported.</p>}},
  author       = {{Broman, Axel and Lenshof, Andreas and Evander, Mikael and Ku, Anson and Ceder, Yvonne and Laurell, Thomas}},
  booktitle    = {{23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019}},
  isbn         = {{9781733419000}},
  keywords     = {{Acoustic trapping; Acoustophoresis; Exosomes; High throughput}},
  language     = {{eng}},
  pages        = {{2--3}},
  publisher    = {{Chemical and Biological Microsystems Society}},
  series       = {{23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019}},
  title        = {{Multinodal high throughput acoustic trapping of exosomes from urine samples}},
  year         = {{2019}},
}