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Effects of oxygen therapy on wall-motion score index in patients with ST elevation myocardial infarction-the randomized SOCCER trial

Khoshnood, Ardavan LU ; Akbarzadeh Mameghanilar, Mahin LU ; Roijer, Anders LU ; Meurling, Carl LU ; Carlsson, Marcus LU ; Bhiladvala, Pallonji LU ; Höglund, Peter LU ; Sparv, David LU ; Todorova, Lizbet LU and Mokhtari, Arash LU , et al. (2017) In Echocardiography 34(8). p.1130-1137
Abstract

Background: Although oxygen (O2) is routinely used in patients with acute myocardial infarction (AMI), it may have negative effects. In this substudy of the SOCCER trial, we aimed to evaluate the effects of O2-treatment on myocardial function in patients with ST elevation myocardial infarction (STEMI). Methods: Normoxic (≥94%) STEMI patients were randomized in the ambulance to either supplemental O2 or room air until the end of the percutaneous coronary intervention (PCI). The patients underwent echocardiography on day 2-3 after the PCI and once again after 6 months. The study endpoints were wall-motion score index (WMSI) and left ventricular ejection fraction (LVEF). Results: Forty-six patients in the... (More)

Background: Although oxygen (O2) is routinely used in patients with acute myocardial infarction (AMI), it may have negative effects. In this substudy of the SOCCER trial, we aimed to evaluate the effects of O2-treatment on myocardial function in patients with ST elevation myocardial infarction (STEMI). Methods: Normoxic (≥94%) STEMI patients were randomized in the ambulance to either supplemental O2 or room air until the end of the percutaneous coronary intervention (PCI). The patients underwent echocardiography on day 2-3 after the PCI and once again after 6 months. The study endpoints were wall-motion score index (WMSI) and left ventricular ejection fraction (LVEF). Results: Forty-six patients in the O2 group and 41 in the air group were included in the analysis. The index echocardiography showed no significant differences between the groups in WMSI (1.32±0.27 for O2 group vs 1.28±0.28 for air group) or LVEF (47.0±8.5% vs 49.2±8.1%). Nor were there differences at 6 months in WMSI (1.16±0.25 vs 1.14±0.24) or LVEF (53.5±5.8% vs 53.5±6.9%). Conclusion: The present findings indicate no harm or benefit of supplemental O2 on myocardial function in STEMI patients. Our results support that it is safe to withhold supplemental O2 in normoxic STEMI patients.

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@article{23e40fa1-d790-4608-afb5-980a3aa6b0c2,
  abstract     = {<p>Background: Although oxygen (O<sub>2</sub>) is routinely used in patients with acute myocardial infarction (AMI), it may have negative effects. In this substudy of the SOCCER trial, we aimed to evaluate the effects of O<sub>2</sub>-treatment on myocardial function in patients with ST elevation myocardial infarction (STEMI). Methods: Normoxic (≥94%) STEMI patients were randomized in the ambulance to either supplemental O<sub>2</sub> or room air until the end of the percutaneous coronary intervention (PCI). The patients underwent echocardiography on day 2-3 after the PCI and once again after 6 months. The study endpoints were wall-motion score index (WMSI) and left ventricular ejection fraction (LVEF). Results: Forty-six patients in the O<sub>2</sub> group and 41 in the air group were included in the analysis. The index echocardiography showed no significant differences between the groups in WMSI (1.32±0.27 for O<sub>2</sub> group vs 1.28±0.28 for air group) or LVEF (47.0±8.5% vs 49.2±8.1%). Nor were there differences at 6 months in WMSI (1.16±0.25 vs 1.14±0.24) or LVEF (53.5±5.8% vs 53.5±6.9%). Conclusion: The present findings indicate no harm or benefit of supplemental O<sub>2</sub> on myocardial function in STEMI patients. Our results support that it is safe to withhold supplemental O<sub>2</sub> in normoxic STEMI patients.</p>},
  author       = {Khoshnood, Ardavan and Akbarzadeh Mameghanilar, Mahin and Roijer, Anders and Meurling, Carl and Carlsson, Marcus and Bhiladvala, Pallonji and Höglund, Peter and Sparv, David and Todorova, Lizbet and Mokhtari, Arash and Erlinge, David and Ekelund, Ulf},
  issn         = {0742-2822},
  keyword      = {Cardiology,Echocardiography,Emergency medicine,Oxygen therapy,ST elevation myocardial infarction},
  language     = {eng},
  number       = {8},
  pages        = {1130--1137},
  publisher    = {Wiley-Blackwell},
  series       = {Echocardiography},
  title        = {Effects of oxygen therapy on wall-motion score index in patients with ST elevation myocardial infarction-the randomized SOCCER trial},
  url          = {http://dx.doi.org/10.1111/echo.13599},
  volume       = {34},
  year         = {2017},
}