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Effects of oxygen therapy on wall-motion score index in patients with ST elevation myocardial infarction-the randomized SOCCER trial

Khoshnood, Ardavan LU ; Akbarzadeh Mameghanilar, Mahin LU ; Roijer, Anders LU ; Meurling, Carl LU ; Carlsson, Marcus LU ; Bhiladvala, Pallonji LU ; Höglund, Peter LU ; Sparv, David LU ; Todorova, Lizbet LU and Mokhtari, Arash LU , et al. (2017) In Echocardiography 34(8). p.1130-1137
Abstract

Background: Although oxygen (O2) is routinely used in patients with acute myocardial infarction (AMI), it may have negative effects. In this substudy of the SOCCER trial, we aimed to evaluate the effects of O2-treatment on myocardial function in patients with ST elevation myocardial infarction (STEMI). Methods: Normoxic (≥94%) STEMI patients were randomized in the ambulance to either supplemental O2 or room air until the end of the percutaneous coronary intervention (PCI). The patients underwent echocardiography on day 2-3 after the PCI and once again after 6 months. The study endpoints were wall-motion score index (WMSI) and left ventricular ejection fraction (LVEF). Results: Forty-six patients in the... (More)

Background: Although oxygen (O2) is routinely used in patients with acute myocardial infarction (AMI), it may have negative effects. In this substudy of the SOCCER trial, we aimed to evaluate the effects of O2-treatment on myocardial function in patients with ST elevation myocardial infarction (STEMI). Methods: Normoxic (≥94%) STEMI patients were randomized in the ambulance to either supplemental O2 or room air until the end of the percutaneous coronary intervention (PCI). The patients underwent echocardiography on day 2-3 after the PCI and once again after 6 months. The study endpoints were wall-motion score index (WMSI) and left ventricular ejection fraction (LVEF). Results: Forty-six patients in the O2 group and 41 in the air group were included in the analysis. The index echocardiography showed no significant differences between the groups in WMSI (1.32±0.27 for O2 group vs 1.28±0.28 for air group) or LVEF (47.0±8.5% vs 49.2±8.1%). Nor were there differences at 6 months in WMSI (1.16±0.25 vs 1.14±0.24) or LVEF (53.5±5.8% vs 53.5±6.9%). Conclusion: The present findings indicate no harm or benefit of supplemental O2 on myocardial function in STEMI patients. Our results support that it is safe to withhold supplemental O2 in normoxic STEMI patients.

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publication status
published
subject
keywords
Cardiology, Echocardiography, Emergency medicine, Oxygen therapy, ST elevation myocardial infarction, wmsi, Wall Motion Score Index
in
Echocardiography
volume
34
issue
8
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85021440738
  • wos:000417419100003
ISSN
0742-2822
DOI
10.1111/echo.13599
language
English
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yes
id
23e40fa1-d790-4608-afb5-980a3aa6b0c2
date added to LUP
2017-08-22 09:24:47
date last changed
2019-01-06 13:22:46
@article{23e40fa1-d790-4608-afb5-980a3aa6b0c2,
  abstract     = {<p>Background: Although oxygen (O<sub>2</sub>) is routinely used in patients with acute myocardial infarction (AMI), it may have negative effects. In this substudy of the SOCCER trial, we aimed to evaluate the effects of O<sub>2</sub>-treatment on myocardial function in patients with ST elevation myocardial infarction (STEMI). Methods: Normoxic (≥94%) STEMI patients were randomized in the ambulance to either supplemental O<sub>2</sub> or room air until the end of the percutaneous coronary intervention (PCI). The patients underwent echocardiography on day 2-3 after the PCI and once again after 6 months. The study endpoints were wall-motion score index (WMSI) and left ventricular ejection fraction (LVEF). Results: Forty-six patients in the O<sub>2</sub> group and 41 in the air group were included in the analysis. The index echocardiography showed no significant differences between the groups in WMSI (1.32±0.27 for O<sub>2</sub> group vs 1.28±0.28 for air group) or LVEF (47.0±8.5% vs 49.2±8.1%). Nor were there differences at 6 months in WMSI (1.16±0.25 vs 1.14±0.24) or LVEF (53.5±5.8% vs 53.5±6.9%). Conclusion: The present findings indicate no harm or benefit of supplemental O<sub>2</sub> on myocardial function in STEMI patients. Our results support that it is safe to withhold supplemental O<sub>2</sub> in normoxic STEMI patients.</p>},
  author       = {Khoshnood, Ardavan and Akbarzadeh Mameghanilar, Mahin and Roijer, Anders and Meurling, Carl and Carlsson, Marcus and Bhiladvala, Pallonji and Höglund, Peter and Sparv, David and Todorova, Lizbet and Mokhtari, Arash and Erlinge, David and Ekelund, Ulf},
  issn         = {0742-2822},
  keyword      = {Cardiology,Echocardiography,Emergency medicine,Oxygen therapy,ST elevation myocardial infarction,wmsi,Wall Motion Score Index},
  language     = {eng},
  number       = {8},
  pages        = {1130--1137},
  publisher    = {Wiley-Blackwell},
  series       = {Echocardiography},
  title        = {Effects of oxygen therapy on wall-motion score index in patients with ST elevation myocardial infarction-the randomized SOCCER trial},
  url          = {http://dx.doi.org/10.1111/echo.13599},
  volume       = {34},
  year         = {2017},
}