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Oxygen therapy in patients with ST elevation myocardial infarction based on the culprit vessel: results from the randomized controlled SOCCER trial

Mokhtari, Arash LU ; Akbarzadeh Mameghanilar, Mahin LU ; Sparv, David LU ; Bhiladvala, Pallonji LU ; Arheden, Håkan LU ; Erlinge, David LU orcid and Khoshnood, Ardavan LU orcid (2020) In BMC Emergency Medicine 20. p.1-10
Abstract
Background: Oxygen (O2) treatment has been a cornerstone in the treatment of patients with myocardial infarction. Recent studies, however, state that supplemental O2 therapy may have no effect or harmful effects in these patients. The aim of this study was thus to evaluate the effect of O2 therapy in patients with ST Elevation Myocardial Infarction (STEMI) based on the culprit vessel; Left Anterior Descending Artery (LAD) or Non-LAD.

Methods: This was a two-center, investigator-initiated, single-blind, parallel-group, randomized controlled trial at the Skåne university hospital, Sweden. A simple computer-generated randomization was used. Patients were either
randomized to standard care with O2 therapy (10 l/min) or air until... (More)
Background: Oxygen (O2) treatment has been a cornerstone in the treatment of patients with myocardial infarction. Recent studies, however, state that supplemental O2 therapy may have no effect or harmful effects in these patients. The aim of this study was thus to evaluate the effect of O2 therapy in patients with ST Elevation Myocardial Infarction (STEMI) based on the culprit vessel; Left Anterior Descending Artery (LAD) or Non-LAD.

Methods: This was a two-center, investigator-initiated, single-blind, parallel-group, randomized controlled trial at the Skåne university hospital, Sweden. A simple computer-generated randomization was used. Patients were either
randomized to standard care with O2 therapy (10 l/min) or air until the end of the primary percutaneous coronary intervention. The patients underwent a Cardiac Magnetic Resonance Imaging (CMRI) days 2–6. The main outcome measures were Myocardium at Risk (MaR), Infarct Size (IS) and Myocardial Salvage Index (MSI) as measured by CMRI, and median high-sensitive troponin T (hs-cTnT).

Results: A total of 229 patients were assessed for eligibility, and 160 of them were randomized to the oxygen or air arm. Because of primarily technical problems with the CMRI, 95 patients were included in the final analyses; 46 in
the oxygen arm and 49 in the air arm. There were no significant differences between patients with LAD and NonLAD as culprit vessel with regard to their allocation (oxygen or air) with regards to MSI, MaR, IS and hs-cTnT.

Conclusion: The results indicate that the location of the culprit vessel has probably no effect on the role of supplemental oxygen therapy in STEMI patients. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ST elevation myocardial infarction, Oxygen, Myocardial infarction, Left anterior descending artery, Cardiac magnetic resonance imaging, Myocardium at risk, Infarct size, Myocardial salvage index, High-sensitive troponin T, Randomized controlled trials, Hjärtinfarkt, STEMI, MR, Hjärt MR
in
BMC Emergency Medicine
volume
20
article number
12
pages
1 - 10
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85079675277
  • pmid:32070283
ISSN
1471-227X
DOI
10.1186/s12873-020-00309-y
project
Prehospital Oxygen Treatment in ST Elevation Myocardial Infarction: The Supplemental Oxygen in Catheterized Coronary Emergency Reperfusion (SOCCER) Study
language
English
LU publication?
yes
id
8b8fcf80-ebee-448d-9ac9-4f93736d33d1
date added to LUP
2020-02-19 00:14:48
date last changed
2024-01-31 17:01:19
@article{8b8fcf80-ebee-448d-9ac9-4f93736d33d1,
  abstract     = {{Background: Oxygen (O2) treatment has been a cornerstone in the treatment of patients with myocardial infarction. Recent studies, however, state that supplemental O2 therapy may have no effect or harmful effects in these patients. The aim of this study was thus to evaluate the effect of O2 therapy in patients with ST Elevation Myocardial Infarction (STEMI) based on the culprit vessel; Left Anterior Descending Artery (LAD) or Non-LAD.<br/><br/>Methods: This was a two-center, investigator-initiated, single-blind, parallel-group, randomized controlled trial at the Skåne university hospital, Sweden. A simple computer-generated randomization was used. Patients were either<br/>randomized to standard care with O2 therapy (10 l/min) or air until the end of the primary percutaneous coronary intervention. The patients underwent a Cardiac Magnetic Resonance Imaging (CMRI) days 2–6. The main outcome measures were Myocardium at Risk (MaR), Infarct Size (IS) and Myocardial Salvage Index (MSI) as measured by CMRI, and median high-sensitive troponin T (hs-cTnT).<br/><br/>Results: A total of 229 patients were assessed for eligibility, and 160 of them were randomized to the oxygen or air arm. Because of primarily technical problems with the CMRI, 95 patients were included in the final analyses; 46 in<br/>the oxygen arm and 49 in the air arm. There were no significant differences between patients with LAD and NonLAD as culprit vessel with regard to their allocation (oxygen or air) with regards to MSI, MaR, IS and hs-cTnT.<br/><br/>Conclusion: The results indicate that the location of the culprit vessel has probably no effect on the role of supplemental oxygen therapy in STEMI patients.}},
  author       = {{Mokhtari, Arash and Akbarzadeh Mameghanilar, Mahin and Sparv, David and Bhiladvala, Pallonji and Arheden, Håkan and Erlinge, David and Khoshnood, Ardavan}},
  issn         = {{1471-227X}},
  keywords     = {{ST elevation myocardial infarction; Oxygen; Myocardial infarction; Left anterior descending artery; Cardiac magnetic resonance imaging; Myocardium at risk; Infarct size; Myocardial salvage index; High-sensitive troponin T; Randomized controlled trials; Hjärtinfarkt; STEMI; MR; Hjärt MR}},
  language     = {{eng}},
  month        = {{02}},
  pages        = {{1--10}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Emergency Medicine}},
  title        = {{Oxygen therapy in patients with ST elevation myocardial infarction based on the culprit vessel: results from the randomized controlled SOCCER trial}},
  url          = {{https://lup.lub.lu.se/search/files/76310019/s12873_020_00309_y.pdf}},
  doi          = {{10.1186/s12873-020-00309-y}},
  volume       = {{20}},
  year         = {{2020}},
}