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Experimental hyperthyroidism stimulates axonal growth in mesothelial chambers

Danielsen, N LU ; Dahlin, L B LU ; Ericson, L E; Crenshaw, Andrew and Lundborg, G LU (1986) In Experimental Neurology 94(1). p.54-65
Abstract

An experimental model is presented for studying axonal growth after experimental hyperthyroidism and hypothyroidism. The left sciatic nerve of the rat was transected and transposed to the back. The proximal nerve stump was inserted into a 50-mm-long mesothelial chamber leaving the distal end of the chamber open. Different groups of young adult rats were given daily injections of thyroxine (10 micrograms/100 g body weight) or the goitrogen, thiamazol, in the drinking water (0.125 g/liter) for 12 weeks. Thyroxine treatment increased significantly the extent of axonal outgrowth from the proximal nerve stump compared with untreated rats. Experimental hypothyroidism (thiamazol treatment), evidenced by a retarded body growth, did not affect... (More)

An experimental model is presented for studying axonal growth after experimental hyperthyroidism and hypothyroidism. The left sciatic nerve of the rat was transected and transposed to the back. The proximal nerve stump was inserted into a 50-mm-long mesothelial chamber leaving the distal end of the chamber open. Different groups of young adult rats were given daily injections of thyroxine (10 micrograms/100 g body weight) or the goitrogen, thiamazol, in the drinking water (0.125 g/liter) for 12 weeks. Thyroxine treatment increased significantly the extent of axonal outgrowth from the proximal nerve stump compared with untreated rats. Experimental hypothyroidism (thiamazol treatment), evidenced by a retarded body growth, did not affect the extent of axonal outgrowth. In other experiments the left proximal nerve stump was cross-anastomosed with the right distal nerve stump. The two nerve stumps were bridged with a mesothelial chamber leaving a 15-mm gap. This gap distance is known from our previous studies to inhibit axonal overgrowth to the distal nerve stump. As evidenced by histological evaluation, in three of six thyroxine-treated rats, axons had bridged the 15-mm gap. We conclude that experimentally induced hyperthyroidism enhances axonal growth in mesothelial chambers.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Animals, Axons, Body Weight, Female, Hyperthyroidism, Hypothyroidism, Methods, Rats, Rats, Inbred Strains, Sciatic Nerve, Journal Article, Research Support, Non-U.S. Gov't
in
Experimental Neurology
volume
94
issue
1
pages
54 - 65
publisher
Academic Press
external identifiers
  • scopus:0022465432
ISSN
0014-4886
DOI
10.1016/0014-4886(86)90271-2
language
English
LU publication?
yes
id
23f36550-ac1d-49fe-ab01-ae85baa35cf7
date added to LUP
2017-10-13 14:08:09
date last changed
2017-11-06 10:23:37
@article{23f36550-ac1d-49fe-ab01-ae85baa35cf7,
  abstract     = {<p>An experimental model is presented for studying axonal growth after experimental hyperthyroidism and hypothyroidism. The left sciatic nerve of the rat was transected and transposed to the back. The proximal nerve stump was inserted into a 50-mm-long mesothelial chamber leaving the distal end of the chamber open. Different groups of young adult rats were given daily injections of thyroxine (10 micrograms/100 g body weight) or the goitrogen, thiamazol, in the drinking water (0.125 g/liter) for 12 weeks. Thyroxine treatment increased significantly the extent of axonal outgrowth from the proximal nerve stump compared with untreated rats. Experimental hypothyroidism (thiamazol treatment), evidenced by a retarded body growth, did not affect the extent of axonal outgrowth. In other experiments the left proximal nerve stump was cross-anastomosed with the right distal nerve stump. The two nerve stumps were bridged with a mesothelial chamber leaving a 15-mm gap. This gap distance is known from our previous studies to inhibit axonal overgrowth to the distal nerve stump. As evidenced by histological evaluation, in three of six thyroxine-treated rats, axons had bridged the 15-mm gap. We conclude that experimentally induced hyperthyroidism enhances axonal growth in mesothelial chambers.</p>},
  author       = {Danielsen, N and Dahlin, L B and Ericson, L E and Crenshaw, Andrew and Lundborg, G},
  issn         = {0014-4886},
  keyword      = {Animals,Axons,Body Weight,Female,Hyperthyroidism,Hypothyroidism,Methods,Rats,Rats, Inbred Strains,Sciatic Nerve,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {1},
  pages        = {54--65},
  publisher    = {Academic Press},
  series       = {Experimental Neurology},
  title        = {Experimental hyperthyroidism stimulates axonal growth in mesothelial chambers},
  url          = {http://dx.doi.org/10.1016/0014-4886(86)90271-2},
  volume       = {94},
  year         = {1986},
}