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Chronically administered islet amyloid polypeptide in rats serves as an adiposity inhibitor and regulates energy homeostasis

Isaksson, B; Wang, F; Permert, J; Olsson, M; Fruin, B; Herrington, M K; Enochsson, L; Erlanson-Albertsson, Charlotte LU and Arnelo, U (2005) In Pancreatology 5(1). p.29-36
Abstract
Aims/Hypothesis: Islet amyloid polypeptide ( IAPP) reduces food intake and body weight in laboratory animals. In addition, IAPP appears to regulate nutrient metabolism. In the present studies, we investigated the effect of chronic IAPP treatment on different aspects of energy homeostasis. Methods: IAPP was infused ( 25 pmol/kg/min) from subcutaneous osmotic pumps for 2 - 7 days. Rats in 2 saline-infused control groups were fed ad libitum (AF) or pair-fed (PF) against the IAPP-treated rats. Results: As expected, the IAPP infusion reduced food intake and body weight gain. In addition, the IAPP treatment decreased the epididymal fat pad ( vs. PF rats, p < 0.05) and lowered circulating levels of triglycerides (vs. PF rats, p < 0.05),... (More)
Aims/Hypothesis: Islet amyloid polypeptide ( IAPP) reduces food intake and body weight in laboratory animals. In addition, IAPP appears to regulate nutrient metabolism. In the present studies, we investigated the effect of chronic IAPP treatment on different aspects of energy homeostasis. Methods: IAPP was infused ( 25 pmol/kg/min) from subcutaneous osmotic pumps for 2 - 7 days. Rats in 2 saline-infused control groups were fed ad libitum (AF) or pair-fed (PF) against the IAPP-treated rats. Results: As expected, the IAPP infusion reduced food intake and body weight gain. In addition, the IAPP treatment decreased the epididymal fat pad ( vs. PF rats, p < 0.05) and lowered circulating levels of triglycerides (vs. PF rats, p < 0.05), free fatty acids ( vs. PF rats, p < 0.05), leptin ( vs. both AF and PF rats, p < 0.05) and insulin ( vs. AF rats, p < 0.05). In contrast, glucose and protein metabolism in the IAPP-treated rats was largely unchanged, as shown in results regarding serum glucose, glucose transport in skeletal muscle, blood urea nitrogen, and glycogen and protein content in the liver and in skeletal muscle. Conclusion/Interpretation: In summary, chronic IAPP exposure led to a changed lipid metabolism, which was characterized by decreased adiposity, hypolipidemia and hypoleptinemia, and to unchanged glucose and protein homeostasis. These results were similar to those seen in rodents during chronic exposure to another satiety/adiposity regulator, leptin. In conclusion, chronically administered IAPP plays a role as a satiety and adiposity signal in rats, and helps regulate energy homeostasis. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
food intake, protein, lipid, glucose, leptin, islet amyloid polypeptide, amylin, rat, adiposity, body weight
in
Pancreatology
volume
5
issue
1
pages
29 - 36
publisher
Karger
external identifiers
  • wos:000228668500006
  • pmid:15775697
  • scopus:18744396393
ISSN
1424-3903
DOI
10.1159/000084488
language
English
LU publication?
yes
id
63aae620-d7c1-43d3-ae3d-34983bb8dd8c (old id 244258)
date added to LUP
2007-08-07 14:24:15
date last changed
2017-03-26 03:28:27
@article{63aae620-d7c1-43d3-ae3d-34983bb8dd8c,
  abstract     = {Aims/Hypothesis: Islet amyloid polypeptide ( IAPP) reduces food intake and body weight in laboratory animals. In addition, IAPP appears to regulate nutrient metabolism. In the present studies, we investigated the effect of chronic IAPP treatment on different aspects of energy homeostasis. Methods: IAPP was infused ( 25 pmol/kg/min) from subcutaneous osmotic pumps for 2 - 7 days. Rats in 2 saline-infused control groups were fed ad libitum (AF) or pair-fed (PF) against the IAPP-treated rats. Results: As expected, the IAPP infusion reduced food intake and body weight gain. In addition, the IAPP treatment decreased the epididymal fat pad ( vs. PF rats, p &lt; 0.05) and lowered circulating levels of triglycerides (vs. PF rats, p &lt; 0.05), free fatty acids ( vs. PF rats, p &lt; 0.05), leptin ( vs. both AF and PF rats, p &lt; 0.05) and insulin ( vs. AF rats, p &lt; 0.05). In contrast, glucose and protein metabolism in the IAPP-treated rats was largely unchanged, as shown in results regarding serum glucose, glucose transport in skeletal muscle, blood urea nitrogen, and glycogen and protein content in the liver and in skeletal muscle. Conclusion/Interpretation: In summary, chronic IAPP exposure led to a changed lipid metabolism, which was characterized by decreased adiposity, hypolipidemia and hypoleptinemia, and to unchanged glucose and protein homeostasis. These results were similar to those seen in rodents during chronic exposure to another satiety/adiposity regulator, leptin. In conclusion, chronically administered IAPP plays a role as a satiety and adiposity signal in rats, and helps regulate energy homeostasis.},
  author       = {Isaksson, B and Wang, F and Permert, J and Olsson, M and Fruin, B and Herrington, M K and Enochsson, L and Erlanson-Albertsson, Charlotte and Arnelo, U},
  issn         = {1424-3903},
  keyword      = {food intake,protein,lipid,glucose,leptin,islet amyloid polypeptide,amylin,rat,adiposity,body weight},
  language     = {eng},
  number       = {1},
  pages        = {29--36},
  publisher    = {Karger},
  series       = {Pancreatology},
  title        = {Chronically administered islet amyloid polypeptide in rats serves as an adiposity inhibitor and regulates energy homeostasis},
  url          = {http://dx.doi.org/10.1159/000084488},
  volume       = {5},
  year         = {2005},
}