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Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p.

Eriksson, Pontus LU ; Aine, Mattias LU ; Sjödahl, Gottfrid LU ; Staaf, Johan LU ; Lindgren, David LU and Höglund, Mattias LU (2013) In PLoS ONE 8(6).
Abstract
Urothelial carcinoma shows frequent amplifications at 6p22 and 1q21-24. The main target gene at 6p22 is believed to be E2F3, frequently co-amplified with CDKAL1 and SOX4. There are however reports on 6p22 amplifications that do not include E2F3. Previous analyses have identified frequent aberrations occurring at 1q21-24. However, due to complex rearrangements it has been difficult to identify specific 1q21-24 target regions and genes.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
8
issue
6
publisher
Public Library of Science
external identifiers
  • wos:000320576400179
  • pmid:23825644
  • scopus:84879176415
ISSN
1932-6203
DOI
10.1371/journal.pone.0067222
language
English
LU publication?
yes
id
248b7d1f-99aa-40c9-9dda-689bca79900d (old id 3956190)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23825644?dopt=Abstract
date added to LUP
2013-08-01 15:22:27
date last changed
2019-05-14 02:15:22
@article{248b7d1f-99aa-40c9-9dda-689bca79900d,
  abstract     = {Urothelial carcinoma shows frequent amplifications at 6p22 and 1q21-24. The main target gene at 6p22 is believed to be E2F3, frequently co-amplified with CDKAL1 and SOX4. There are however reports on 6p22 amplifications that do not include E2F3. Previous analyses have identified frequent aberrations occurring at 1q21-24. However, due to complex rearrangements it has been difficult to identify specific 1q21-24 target regions and genes.},
  articleno    = {e67222},
  author       = {Eriksson, Pontus and Aine, Mattias and Sjödahl, Gottfrid and Staaf, Johan and Lindgren, David and Höglund, Mattias},
  issn         = {1932-6203},
  language     = {eng},
  number       = {6},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0067222},
  volume       = {8},
  year         = {2013},
}