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Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies

Beral, V.; Hermon, C.; Peto, R.; Reeves, G.; Brinton, L.; Marchbanks, P.; Negri, E.; Ness, R.; Peeters, P. H. M. and Vessey, M., et al. (2012) In PLoS Medicine 9(4).
Abstract
Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with ovarian cancer and 81,311 women without ovarian cancer from 47 epidemiological studies were collected, checked, and analysed centrally. Adjusted relative risks of ovarian cancer were calculated, by height and by body mass index. Ovarian cancer risk increased significantly with height and with body mass index, except in studies using hospital... (More)
Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with ovarian cancer and 81,311 women without ovarian cancer from 47 epidemiological studies were collected, checked, and analysed centrally. Adjusted relative risks of ovarian cancer were calculated, by height and by body mass index. Ovarian cancer risk increased significantly with height and with body mass index, except in studies using hospital controls. For other study designs, the relative risk of ovarian cancer per 5 cm increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09; p<0.001); this relationship did not vary significantly by women's age, year of birth, education, age at menarche, parity, menopausal status, smoking, alcohol consumption, having had a hysterectomy, having first degree relatives with ovarian or breast cancer, use of oral contraceptives, or use of menopausal hormone therapy. For body mass index, there was significant heterogeneity (p<0.001) in the findings between ever-users and never-users of menopausal hormone therapy, but not by the 11 other factors listed above. The relative risk for ovarian cancer per 5 kg/m(2) increase in body mass index was 1.10 (95% CI, 1.07-1.13; p<0.001) in never-users and 0.95 (95% CI, 0.92-0.99; p = 0.02) in ever-users of hormone therapy. Conclusions: Ovarian cancer is associated with height and, among never-users of hormone therapy, with body mass index. In high-income countries, both height and body mass index have been increasing in birth cohorts now developing the disease. If all other relevant factors had remained constant, then these increases in height and weight would be associated with a 3% increase in ovarian cancer incidence per decade. (Less)
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PLoS Medicine
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9
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4
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Public Library of Science
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  • wos:000303393800003
  • scopus:84860157091
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1549-1676
DOI
10.1371/journal.pmed.1001200
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English
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cb3ca67a-2b8c-42a3-8f5b-41d963f977dc (old id 2570518)
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@article{cb3ca67a-2b8c-42a3-8f5b-41d963f977dc,
  abstract     = {Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with ovarian cancer and 81,311 women without ovarian cancer from 47 epidemiological studies were collected, checked, and analysed centrally. Adjusted relative risks of ovarian cancer were calculated, by height and by body mass index. Ovarian cancer risk increased significantly with height and with body mass index, except in studies using hospital controls. For other study designs, the relative risk of ovarian cancer per 5 cm increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09; p&lt;0.001); this relationship did not vary significantly by women's age, year of birth, education, age at menarche, parity, menopausal status, smoking, alcohol consumption, having had a hysterectomy, having first degree relatives with ovarian or breast cancer, use of oral contraceptives, or use of menopausal hormone therapy. For body mass index, there was significant heterogeneity (p&lt;0.001) in the findings between ever-users and never-users of menopausal hormone therapy, but not by the 11 other factors listed above. The relative risk for ovarian cancer per 5 kg/m(2) increase in body mass index was 1.10 (95% CI, 1.07-1.13; p&lt;0.001) in never-users and 0.95 (95% CI, 0.92-0.99; p = 0.02) in ever-users of hormone therapy. Conclusions: Ovarian cancer is associated with height and, among never-users of hormone therapy, with body mass index. In high-income countries, both height and body mass index have been increasing in birth cohorts now developing the disease. If all other relevant factors had remained constant, then these increases in height and weight would be associated with a 3% increase in ovarian cancer incidence per decade.},
  author       = {Beral, V. and Hermon, C. and Peto, R. and Reeves, G. and Brinton, L. and Marchbanks, P. and Negri, E. and Ness, R. and Peeters, P. H. M. and Vessey, M. and Calle, E. E. and Gapstur, S. M. and Patel, A. V. and Dal Maso, L. and Talamini, R. and Chetrit, A. and Hirsh-Yechezkel, G. and Lubin, F. and Sadetzki, S. and Allen, N. and Bull, D. and Callaghan, K. and Crossley, B. and Gaitskell, K. and Goodill, A. and Green, J. and Key, T. and Moser, K. and Collins, R. and Doll, R. and Gonzalez, C. A. and Lee, N. and Ory, H. W. and Peterson, H. B. and Wingo, P. A. and Martin, N. and Pardthaisong, T. and Silpisornkosol, S. and Theetranont, C. and Boosiri, B. and Chutivongse, S. and Jimakorn, P. and Virutamasen, P. and Wongsrichanalai, C. and Tjonneland, A. and Titus-Ernstoff, L. and Byers, T. and Rohan, T. and Mosgaard, B. J. and Yeates, D. and Freudenheim, J. L. and Chang-Claude, J. and Kaaks, R. and Anderson, K. E. and Folsom, A. and Robien, K. and Rossing, M. A. and Thomas, D. B. and Weiss, N. S. and Riboli, E. and Clavel-Chapelon, F. and Cramer, D. and Hankinson, S. E. and Tworoger, S. S. and Franceschi, S. and La Vecchia, C. and Magnusson, C. and Riman, T. and Weiderpass, E. and Wolk, A. and Schouten, L. J. and van den Brandt, P. A. and Chantarakul, N. and Koetsawang, S. and Rachawat, D. and Palli, D. and Black, A. and de Gonzalez, A. Berrington and Freedman, D. M. and Hartge, P. and Hsing, A. W. and Lacey Jr, J. V. and Hoover, R. N. and Schairer, C. and Graff-Iversen, S. and Selmer, R. and Bain, C. J. and Green, A. C. and Purdie, D. M. and Siskind, V. and Webb, P. M. and McCann, S. E. and Hannaford, P. and Kay, C. and Binns, C. W. and Lee, A. H. and Zhang, M. and Ness, R. B. and Nasca, P. and Coogan, P. F. and Palmer, J. R. and Rosenberg, L. and Kelsey, J. and Paffenbarger, R. and Whittemore, A. and Katsouyanni, K. and Trichopoulou, A. and Trichopoulos, D. and Tzonou, A. and Dabancens, A. and Martinez, L. and Molina, R. and Salas, O. and Goodman, M. T. and Lurie, G. and Carney, M. E. and Wilkens, L. R. and Werner Hartman, Linda and Manjer, Jonas and Olsson, Håkan and Grisso, J. A. and Morgan, M. and Wheeler, J. E. and Casagrande, J. and Pike, M. C. and Ross, R. K. and Wu, A. H. and Miller, A. B. and Kumle, M. and Lund, E. and McGowan, L. and Shu, X. O. and Zheng, W. and Farley, T. M. M. and Holck, S. and Meirik, O. and Risch, H. A.},
  issn         = {1549-1676},
  language     = {eng},
  number       = {4},
  publisher    = {Public Library of Science},
  series       = {PLoS Medicine},
  title        = {Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies},
  url          = {http://dx.doi.org/10.1371/journal.pmed.1001200},
  volume       = {9},
  year         = {2012},
}