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X-ray structure analysis of free-standing lipid membranes facilitated by micromachined apertures

Beerlink, André ; Wilbrandt, P. J. ; Ziegler, E. ; Carbone, D. LU ; Metzger, T. H. and Salditt, Tim (2008) In Langmuir 24(9). p.4952-4958
Abstract

Silicon and Teflon substrates have been structured by wet etching and a focused ion beam (FIB) to obtain very defined, clean apertures. Planar, free-standing lipid membranes (black lipid membranes (BLM)) with enhanced long-term stability have been prepared on these apertures by the methods of Montal and Müller1.2 as well as Müller and Rudin. 3 The stability and geometric control enables the use of X-ray analysis of free-standing single bilayers. With the presented setup, simultaneous structural and electrophysiological measurements will become feasible.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Langmuir
volume
24
issue
9
pages
7 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:18370435
  • scopus:44249127772
ISSN
0743-7463
DOI
10.1021/la703704x
language
English
LU publication?
no
id
25aa24ee-d6ca-4cba-a11f-b8a6e7329ebd
date added to LUP
2021-12-15 11:54:46
date last changed
2025-10-14 10:17:30
@article{25aa24ee-d6ca-4cba-a11f-b8a6e7329ebd,
  abstract     = {{<p>Silicon and Teflon substrates have been structured by wet etching and a focused ion beam (FIB) to obtain very defined, clean apertures. Planar, free-standing lipid membranes (black lipid membranes (BLM)) with enhanced long-term stability have been prepared on these apertures by the methods of Montal and Müller<sup>1.2</sup> as well as Müller and Rudin. <sup>3</sup> The stability and geometric control enables the use of X-ray analysis of free-standing single bilayers. With the presented setup, simultaneous structural and electrophysiological measurements will become feasible.</p>}},
  author       = {{Beerlink, André and Wilbrandt, P. J. and Ziegler, E. and Carbone, D. and Metzger, T. H. and Salditt, Tim}},
  issn         = {{0743-7463}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{9}},
  pages        = {{4952--4958}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Langmuir}},
  title        = {{X-ray structure analysis of free-standing lipid membranes facilitated by micromachined apertures}},
  url          = {{http://dx.doi.org/10.1021/la703704x}},
  doi          = {{10.1021/la703704x}},
  volume       = {{24}},
  year         = {{2008}},
}