Risk factors and incidence of new-onset heart failure with conventional pacemakerimplant – a nationwide study
(2024) In Heart Rhythm O2- Abstract
- Background
Studies have shown that the risk of new-onset heart failure (HF) is higher post-implant for patients receiving right ventricular pacing.
Objective
This study aimed to investigate incidence, risk factors and implications for long-term prognosis of new-onset HF in patients after pacemaker-implant.
Methods
Patients without preexisting HF who received a pacemaker in Sweden during the period 2005-2020 were identified via the nationwide Pacemaker Registry. Data was crossmatched with the population registry and national disease registries. Primary outcome was new-onset HF within 5 years, and a risk score for this was developed and validated..
Results
In all, 65579 patients met the inclusion... (More) - Background
Studies have shown that the risk of new-onset heart failure (HF) is higher post-implant for patients receiving right ventricular pacing.
Objective
This study aimed to investigate incidence, risk factors and implications for long-term prognosis of new-onset HF in patients after pacemaker-implant.
Methods
Patients without preexisting HF who received a pacemaker in Sweden during the period 2005-2020 were identified via the nationwide Pacemaker Registry. Data was crossmatched with the population registry and national disease registries. Primary outcome was new-onset HF within 5 years, and a risk score for this was developed and validated..
Results
In all, 65579 patients met the inclusion criteria (10351 single chamber ventricular and 55228 dual chamber pacemakers). 13792 (21.0%) patients were diagnosed with HF within five years post-implant. Of these, 6244 (45.3%) were hospitalized for HF. Patients with new-onset heart failure were more likely to die within five years (41.2% vs. 19.7%, p<0.0001). Risk factors for new-onset HF included increasing age, male sex, hypertension, diabetes, atrial fibrillation, chronic lung- and kidney disease, ischemic heart disease, and AV block. In a combined score using these variables, patients in the highest risk-score quartile had a hazard ratio of 5.36 [4.91-5.86] (p<0.001) and an absolute risk of 32% for developing HF.
Conclusion
Pacemaker therapy is associated with >20% risk of new-onset HF within five years, and we identified nine risk factors associated with the diagnosis of new-onset HF. The proposed score based on these variables can be used to identify patients at high risk for new-onset heart failure (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/25d5e770-0eff-45a8-8584-cabf798597bb
- author
- Farouq, Maiwand
LU
; Rorsman Schough, Cecilia
LU
; Marinko, Sofia
LU
; Mortsell, David
LU
; Chaudhry, Uzma LU ; Wang, Lingwei LU
; Platonov, Pyotr LU and Borgquist, Rasmus LU
- organization
- publishing date
- 2024-07-17
- type
- Contribution to journal
- publication status
- in press
- subject
- in
- Heart Rhythm O2
- publisher
- Elsevier
- ISSN
- 2666-5018
- DOI
- 10.1016/j.hroo.2024.07.012
- language
- English
- LU publication?
- yes
- id
- 25d5e770-0eff-45a8-8584-cabf798597bb
- date added to LUP
- 2024-07-24 12:31:59
- date last changed
- 2024-07-25 12:32:16
@article{25d5e770-0eff-45a8-8584-cabf798597bb, abstract = {{Background<br/>Studies have shown that the risk of new-onset heart failure (HF) is higher post-implant for patients receiving right ventricular pacing.<br/><br/>Objective<br/>This study aimed to investigate incidence, risk factors and implications for long-term prognosis of new-onset HF in patients after pacemaker-implant.<br/><br/>Methods<br/>Patients without preexisting HF who received a pacemaker in Sweden during the period 2005-2020 were identified via the nationwide Pacemaker Registry. Data was crossmatched with the population registry and national disease registries. Primary outcome was new-onset HF within 5 years, and a risk score for this was developed and validated..<br/><br/>Results<br/>In all, 65579 patients met the inclusion criteria (10351 single chamber ventricular and 55228 dual chamber pacemakers). 13792 (21.0%) patients were diagnosed with HF within five years post-implant. Of these, 6244 (45.3%) were hospitalized for HF. Patients with new-onset heart failure were more likely to die within five years (41.2% vs. 19.7%, p<0.0001). Risk factors for new-onset HF included increasing age, male sex, hypertension, diabetes, atrial fibrillation, chronic lung- and kidney disease, ischemic heart disease, and AV block. In a combined score using these variables, patients in the highest risk-score quartile had a hazard ratio of 5.36 [4.91-5.86] (p<0.001) and an absolute risk of 32% for developing HF.<br/><br/>Conclusion<br/>Pacemaker therapy is associated with >20% risk of new-onset HF within five years, and we identified nine risk factors associated with the diagnosis of new-onset HF. The proposed score based on these variables can be used to identify patients at high risk for new-onset heart failure}}, author = {{Farouq, Maiwand and Rorsman Schough, Cecilia and Marinko, Sofia and Mortsell, David and Chaudhry, Uzma and Wang, Lingwei and Platonov, Pyotr and Borgquist, Rasmus}}, issn = {{2666-5018}}, language = {{eng}}, month = {{07}}, publisher = {{Elsevier}}, series = {{Heart Rhythm O2}}, title = {{Risk factors and incidence of new-onset heart failure with conventional pacemakerimplant – a nationwide study}}, url = {{http://dx.doi.org/10.1016/j.hroo.2024.07.012}}, doi = {{10.1016/j.hroo.2024.07.012}}, year = {{2024}}, }