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Nuclear microprobe analysis of the selective boron uptake obtained with BPA in brain tumour tissue

Wegdén, Marie LU ; Kristiansson, Per LU ; Ceberg, Crister LU ; Munck af Rosenschöld, Per LU ; Auzelyte, Vaida LU ; Elfman, Mikael LU ; Malmqvist, Klas LU ; Nilsson, Christer LU ; Pallon, Jan LU and Shariff, Asad LU (2004) In Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 219-20. p.67-71
Abstract
The tumour selective ability of the boron compound boronophenylalanine (BPA), today used in Boron Neutron Capture Therapy in Sweden, has been investigated with the Lund Nuclear Microprobe. The tumour to tissue ratio of the boron concentration, as well as the location of boron within the cells, is critical for the efficiency of the therapy. It is desirable that the boron is accumulated as close as possible to the cell nucleus, since the alpha particles produced in the B-10(n,alpha)Li-7 reaction only have a range of about 10 microns, i.e. a cell diameter. The nuclear reaction B-11(p,alpha)2alpha, which has an especially high cross-section (300 mb) for 660 keV protons, has been used to analyse brain tissue from BPA-injected rats. Previous... (More)
The tumour selective ability of the boron compound boronophenylalanine (BPA), today used in Boron Neutron Capture Therapy in Sweden, has been investigated with the Lund Nuclear Microprobe. The tumour to tissue ratio of the boron concentration, as well as the location of boron within the cells, is critical for the efficiency of the therapy. It is desirable that the boron is accumulated as close as possible to the cell nucleus, since the alpha particles produced in the B-10(n,alpha)Li-7 reaction only have a range of about 10 microns, i.e. a cell diameter. The nuclear reaction B-11(p,alpha)2alpha, which has an especially high cross-section (300 mb) for 660 keV protons, has been used to analyse brain tissue from BPA-injected rats. Previous studies on other boron compounds have shown significant background problems when the alpha particles are detected in the backward direction. By a specially designed set-up, alpha particles in the forward and backward direction are detected simultaneously, and only the coincidences between the two directions are considered to be true boron events. In this way we could achieve excellent background suppression. The analysis shows that BPA indeed is tumour selective. Quantifications show a boron abundance of 150 +/- 20 ng/cm(2) in normal tissue and 567 70 ng/cm(2) in tumour tissue. If the rat is fed with L-dopa before the injection of BPA the uptake increases 3-4 times. The boron is homogeneously distributed in the cellular structure and no specific intracellular accumulation has been shown. (C) 2004 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coincidence, BPA, boron, BNCT, tumour tissue, NRA
in
Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
volume
219-20
pages
67 - 71
publisher
Elsevier
external identifiers
  • wos:000221895800014
  • other:CODEN: NIMBEU
  • scopus:2342541046
ISSN
0168-583X
DOI
10.1016/j.nimb.2004.01.029
language
English
LU publication?
yes
id
b5e10e67-6c78-462c-bb47-d7423fb699a3 (old id 275105)
date added to LUP
2007-12-20 16:45:22
date last changed
2017-01-01 06:50:46
@article{b5e10e67-6c78-462c-bb47-d7423fb699a3,
  abstract     = {The tumour selective ability of the boron compound boronophenylalanine (BPA), today used in Boron Neutron Capture Therapy in Sweden, has been investigated with the Lund Nuclear Microprobe. The tumour to tissue ratio of the boron concentration, as well as the location of boron within the cells, is critical for the efficiency of the therapy. It is desirable that the boron is accumulated as close as possible to the cell nucleus, since the alpha particles produced in the B-10(n,alpha)Li-7 reaction only have a range of about 10 microns, i.e. a cell diameter. The nuclear reaction B-11(p,alpha)2alpha, which has an especially high cross-section (300 mb) for 660 keV protons, has been used to analyse brain tissue from BPA-injected rats. Previous studies on other boron compounds have shown significant background problems when the alpha particles are detected in the backward direction. By a specially designed set-up, alpha particles in the forward and backward direction are detected simultaneously, and only the coincidences between the two directions are considered to be true boron events. In this way we could achieve excellent background suppression. The analysis shows that BPA indeed is tumour selective. Quantifications show a boron abundance of 150 +/- 20 ng/cm(2) in normal tissue and 567 70 ng/cm(2) in tumour tissue. If the rat is fed with L-dopa before the injection of BPA the uptake increases 3-4 times. The boron is homogeneously distributed in the cellular structure and no specific intracellular accumulation has been shown. (C) 2004 Elsevier B.V. All rights reserved.},
  author       = {Wegdén, Marie and Kristiansson, Per and Ceberg, Crister and Munck af Rosenschöld, Per and Auzelyte, Vaida and Elfman, Mikael and Malmqvist, Klas and Nilsson, Christer and Pallon, Jan and Shariff, Asad},
  issn         = {0168-583X},
  keyword      = {coincidence,BPA,boron,BNCT,tumour tissue,NRA},
  language     = {eng},
  pages        = {67--71},
  publisher    = {Elsevier},
  series       = {Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms},
  title        = {Nuclear microprobe analysis of the selective boron uptake obtained with BPA in brain tumour tissue},
  url          = {http://dx.doi.org/10.1016/j.nimb.2004.01.029},
  volume       = {219-20},
  year         = {2004},
}