Consequences on islet and incretin hormone responses to dinner by omission of lunch in healthy men
(2020) In Endocrinology, Diabetes & Metabolism 3(3).- Abstract
Background: Omission of breakfast results in higher glucose and lower insulin and incretin hormone levels after both lunch and dinner. Whether omission of lunch has a similar impact on the following meal is not known. Aim: This study therefore explored whether omission of lunch ingestion affects glucose, islet and incretin hormones after dinner ingestion in healthy subjects. Materials & Methods: Twelve male volunteers (mean age 22 years, BMI 22.5 kg/m2) underwent two test days in random order with standard breakfast and dinner on both days with provision or omission of standard lunch in between. Results: The results showed that throughout the 300 minutes study period, glucose, insulin, glucagon and GIP levels after dinner... (More)
Background: Omission of breakfast results in higher glucose and lower insulin and incretin hormone levels after both lunch and dinner. Whether omission of lunch has a similar impact on the following meal is not known. Aim: This study therefore explored whether omission of lunch ingestion affects glucose, islet and incretin hormones after dinner ingestion in healthy subjects. Materials & Methods: Twelve male volunteers (mean age 22 years, BMI 22.5 kg/m2) underwent two test days in random order with standard breakfast and dinner on both days with provision or omission of standard lunch in between. Results: The results showed that throughout the 300 minutes study period, glucose, insulin, glucagon and GIP levels after dinner ingestion did not differ between the two tests. In contrast, C-peptide, and GLP-1 levels were 26%-35% higher at later time points after dinner ingestion when lunch had been omitted (P <.05). Conclusion: We conclude that omission of lunch increases GLP-1 and insulin secretion and possibly also insulin clearance resulting in unchanged glucose and insulin levels after dinner ingestion.
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- author
- Lindgren, Ola LU and Ahrén, Bo LU
- organization
- publishing date
- 2020-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- C-peptide, dinner, GIP, GLP-1, glucagon, insulin, lunch
- in
- Endocrinology, Diabetes & Metabolism
- volume
- 3
- issue
- 3
- article number
- e00141
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85084243485
- pmid:32704562
- ISSN
- 2398-9238
- DOI
- 10.1002/edm2.141
- language
- English
- LU publication?
- yes
- id
- 279063e3-1190-4b6a-adba-6eec4a1c0c86
- date added to LUP
- 2020-06-10 14:22:32
- date last changed
- 2024-04-03 08:45:04
@article{279063e3-1190-4b6a-adba-6eec4a1c0c86,
abstract = {{<p>Background: Omission of breakfast results in higher glucose and lower insulin and incretin hormone levels after both lunch and dinner. Whether omission of lunch has a similar impact on the following meal is not known. Aim: This study therefore explored whether omission of lunch ingestion affects glucose, islet and incretin hormones after dinner ingestion in healthy subjects. Materials & Methods: Twelve male volunteers (mean age 22 years, BMI 22.5 kg/m<sup>2</sup>) underwent two test days in random order with standard breakfast and dinner on both days with provision or omission of standard lunch in between. Results: The results showed that throughout the 300 minutes study period, glucose, insulin, glucagon and GIP levels after dinner ingestion did not differ between the two tests. In contrast, C-peptide, and GLP-1 levels were 26%-35% higher at later time points after dinner ingestion when lunch had been omitted (P <.05). Conclusion: We conclude that omission of lunch increases GLP-1 and insulin secretion and possibly also insulin clearance resulting in unchanged glucose and insulin levels after dinner ingestion.</p>}},
author = {{Lindgren, Ola and Ahrén, Bo}},
issn = {{2398-9238}},
keywords = {{C-peptide; dinner; GIP; GLP-1; glucagon; insulin; lunch}},
language = {{eng}},
number = {{3}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Endocrinology, Diabetes & Metabolism}},
title = {{Consequences on islet and incretin hormone responses to dinner by omission of lunch in healthy men}},
url = {{http://dx.doi.org/10.1002/edm2.141}},
doi = {{10.1002/edm2.141}},
volume = {{3}},
year = {{2020}},
}