Advanced

Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C

Hellstrand, Sophie LU ; Sonestedt, Emily LU ; Ericson, Ulrika LU ; Gullberg, Bo LU ; Wirfält, Elisabet LU ; Hedblad, Bo LU and Orho-Melander, Marju LU (2012) In Journal of Lipid Research 53(6). p.1183-1189
Abstract
Polymorphisms of the FA desaturase (FADS) gene cluster have been associated with LDL, HDL, and triglyceride concentrations. Because FADS converts alpha-linolenic acid (ALA) and linoleic acid into PUFAs, we investigated the interaction between different PUFA intakes and the FADS polymorphism rs174547 (T>C) on fasting blood lipid and lipoprotein concentrations. We included 4,635 individuals (60% females, 45-68 years) from the Swedish population-based Malmo Diet and Cancer cohort. Dietary intakes were assessed by a modified diet history method including 7-day registration of cooked meals. The C-allele of rs174547 was associated with lower LDL concentration (P = 0.03). We observed significant interaction between rs174547 and long-chain... (More)
Polymorphisms of the FA desaturase (FADS) gene cluster have been associated with LDL, HDL, and triglyceride concentrations. Because FADS converts alpha-linolenic acid (ALA) and linoleic acid into PUFAs, we investigated the interaction between different PUFA intakes and the FADS polymorphism rs174547 (T>C) on fasting blood lipid and lipoprotein concentrations. We included 4,635 individuals (60% females, 45-68 years) from the Swedish population-based Malmo Diet and Cancer cohort. Dietary intakes were assessed by a modified diet history method including 7-day registration of cooked meals. The C-allele of rs174547 was associated with lower LDL concentration (P = 0.03). We observed significant interaction between rs174547 and long-chain omega-3 PUFA intakes on LDL (P = 0.01); the C-allele was only associated with lower LDL among individuals in the lowest tertile of long-chain omega-3 PUFA intakes (P < 0.001). In addition, significant interaction was observed between rs174547 and the ratio of ALA and linoleic FA intakes on HDL (P = 0.03). However, no significant associations between the C-allele and HDL were detected within the intake tertiles of the ratio. Our findings suggest that dietary intake levels of different PUFAs modify the associated effect of genetic variation in FADS on LDL and HDL.-Hellstrand, S., E. Sonestedt, U. Ericson, B. Gullberg, E. Wirfalt, B. Hedblad, and M. Orho-Melander. Intake levels of dietary PUFAs modify the association between genetic variation in FADS and LDL-C. J. Lipid Res. 2012. 53: 1183-1189. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diet, fatty acid desaturase, polyunsaturated fatty acids, cholesterol, cohort, epidemiology, low density lipoprotein cholesterol
in
Journal of Lipid Research
volume
53
issue
6
pages
1183 - 1189
publisher
American Society for Biochemistry and Molecular Biology
external identifiers
  • wos:000303913200015
  • scopus:84861446749
ISSN
1539-7262
DOI
10.1194/jlr.P023721
language
English
LU publication?
yes
id
01e66bb3-1ee2-4805-adcc-2c73691f9564 (old id 2826508)
date added to LUP
2012-07-03 10:26:19
date last changed
2017-06-18 03:25:06
@article{01e66bb3-1ee2-4805-adcc-2c73691f9564,
  abstract     = {Polymorphisms of the FA desaturase (FADS) gene cluster have been associated with LDL, HDL, and triglyceride concentrations. Because FADS converts alpha-linolenic acid (ALA) and linoleic acid into PUFAs, we investigated the interaction between different PUFA intakes and the FADS polymorphism rs174547 (T&gt;C) on fasting blood lipid and lipoprotein concentrations. We included 4,635 individuals (60% females, 45-68 years) from the Swedish population-based Malmo Diet and Cancer cohort. Dietary intakes were assessed by a modified diet history method including 7-day registration of cooked meals. The C-allele of rs174547 was associated with lower LDL concentration (P = 0.03). We observed significant interaction between rs174547 and long-chain omega-3 PUFA intakes on LDL (P = 0.01); the C-allele was only associated with lower LDL among individuals in the lowest tertile of long-chain omega-3 PUFA intakes (P &lt; 0.001). In addition, significant interaction was observed between rs174547 and the ratio of ALA and linoleic FA intakes on HDL (P = 0.03). However, no significant associations between the C-allele and HDL were detected within the intake tertiles of the ratio. Our findings suggest that dietary intake levels of different PUFAs modify the associated effect of genetic variation in FADS on LDL and HDL.-Hellstrand, S., E. Sonestedt, U. Ericson, B. Gullberg, E. Wirfalt, B. Hedblad, and M. Orho-Melander. Intake levels of dietary PUFAs modify the association between genetic variation in FADS and LDL-C. J. Lipid Res. 2012. 53: 1183-1189.},
  author       = {Hellstrand, Sophie and Sonestedt, Emily and Ericson, Ulrika and Gullberg, Bo and Wirfält, Elisabet and Hedblad, Bo and Orho-Melander, Marju},
  issn         = {1539-7262},
  keyword      = {diet,fatty acid desaturase,polyunsaturated fatty acids,cholesterol,cohort,epidemiology,low density lipoprotein cholesterol},
  language     = {eng},
  number       = {6},
  pages        = {1183--1189},
  publisher    = {American Society for Biochemistry and Molecular Biology},
  series       = {Journal of Lipid Research},
  title        = {Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C},
  url          = {http://dx.doi.org/10.1194/jlr.P023721},
  volume       = {53},
  year         = {2012},
}