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A Compartmental Model for Biokinetics and Dosimetry of 18F-Choline in Prostate Cancer Patients

Giussani, Augusto; Janzen, Tilman; Uusijärvi, Helena LU ; Tavola, Federico; Zankl, Maria; Sydoff, Marie LU ; Bjartell, Anders LU ; Leide Svegborn, Sigrid LU ; Söderberg, Marcus LU and Mattsson, Sören LU , et al. (2012) In Journal of Nuclear Medicine 53(6). p.985-993
Abstract
PET with F-18-choline (F-18-FCH) is used in the diagnosis of prostate cancer and its recurrences. In this work, biodistribution data from a recent study conducted at Skane University Hospital Malmo were used for the development of a biokinetic and dosimetric model. Methods: The biodistribution of F-18-FCH was followed for 10 patients using PET up to 4 h after administration. Activity concentrations in blood and urine samples were also determined. A compartmental model structure was developed, and values of the model parameters were obtained for each single patient and for a reference patient using a population kinetic approach. Radiation doses to the organs were determined using computational (voxel) phantoms for the determination of the S... (More)
PET with F-18-choline (F-18-FCH) is used in the diagnosis of prostate cancer and its recurrences. In this work, biodistribution data from a recent study conducted at Skane University Hospital Malmo were used for the development of a biokinetic and dosimetric model. Methods: The biodistribution of F-18-FCH was followed for 10 patients using PET up to 4 h after administration. Activity concentrations in blood and urine samples were also determined. A compartmental model structure was developed, and values of the model parameters were obtained for each single patient and for a reference patient using a population kinetic approach. Radiation doses to the organs were determined using computational (voxel) phantoms for the determination of the S factors. Results: The model structure consists of a central exchange compartment (blood), 2 compartments each for the liver and kidneys, 1 for spleen, 1 for urinary bladder, and 1 generic compartment accounting for the remaining material. The model can successfully describe the individual patients' data. The parameters showing the greatest interindividual variations are the blood volume (the clearance process is rapid, and early blood data are not available for several patients) and the transfer out from liver (the physical half-life of F-18 is too short to follow this long-term process with the necessary accuracy). The organs receiving the highest doses are the kidneys (reference patient, 0.079 mGy/MBq; individual values, 0.033-0.105 mGy/MBq) and the liver (reference patient, 0.062 mGy/MBq; individual values, 0.036-0.082 mGy/MBq). The dose to the urinary bladder wall of the reference patient varies between 0.017 and 0.030 mGy/MBq, depending on the assumptions on bladder voiding. Conclusion: The model gives a satisfactory description of the biodistribution of F-18-FCH and realistic estimates of the radiation dose received by the patients. (Less)
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Contribution to journal
publication status
published
subject
keywords
PET, F-18-choline, prostate carcinoma, biokinetics, dosimetry
in
Journal of Nuclear Medicine
volume
53
issue
6
pages
985 - 993
publisher
Society of Nuclear Medicine
external identifiers
  • wos:000305040900044
  • scopus:84861876807
ISSN
0161-5505
DOI
10.2967/jnumed.111.099408
language
English
LU publication?
yes
id
e21d82be-1c4e-4723-9e6a-6deaad81f294 (old id 2835580)
date added to LUP
2012-07-24 11:18:20
date last changed
2017-03-19 03:09:28
@article{e21d82be-1c4e-4723-9e6a-6deaad81f294,
  abstract     = {PET with F-18-choline (F-18-FCH) is used in the diagnosis of prostate cancer and its recurrences. In this work, biodistribution data from a recent study conducted at Skane University Hospital Malmo were used for the development of a biokinetic and dosimetric model. Methods: The biodistribution of F-18-FCH was followed for 10 patients using PET up to 4 h after administration. Activity concentrations in blood and urine samples were also determined. A compartmental model structure was developed, and values of the model parameters were obtained for each single patient and for a reference patient using a population kinetic approach. Radiation doses to the organs were determined using computational (voxel) phantoms for the determination of the S factors. Results: The model structure consists of a central exchange compartment (blood), 2 compartments each for the liver and kidneys, 1 for spleen, 1 for urinary bladder, and 1 generic compartment accounting for the remaining material. The model can successfully describe the individual patients' data. The parameters showing the greatest interindividual variations are the blood volume (the clearance process is rapid, and early blood data are not available for several patients) and the transfer out from liver (the physical half-life of F-18 is too short to follow this long-term process with the necessary accuracy). The organs receiving the highest doses are the kidneys (reference patient, 0.079 mGy/MBq; individual values, 0.033-0.105 mGy/MBq) and the liver (reference patient, 0.062 mGy/MBq; individual values, 0.036-0.082 mGy/MBq). The dose to the urinary bladder wall of the reference patient varies between 0.017 and 0.030 mGy/MBq, depending on the assumptions on bladder voiding. Conclusion: The model gives a satisfactory description of the biodistribution of F-18-FCH and realistic estimates of the radiation dose received by the patients.},
  author       = {Giussani, Augusto and Janzen, Tilman and Uusijärvi, Helena and Tavola, Federico and Zankl, Maria and Sydoff, Marie and Bjartell, Anders and Leide Svegborn, Sigrid and Söderberg, Marcus and Mattsson, Sören and Hoeschen, Christoph and Cantone, Marie-Claire},
  issn         = {0161-5505},
  keyword      = {PET,F-18-choline,prostate carcinoma,biokinetics,dosimetry},
  language     = {eng},
  number       = {6},
  pages        = {985--993},
  publisher    = {Society of Nuclear Medicine},
  series       = {Journal of Nuclear Medicine},
  title        = {A Compartmental Model for Biokinetics and Dosimetry of 18F-Choline in Prostate Cancer Patients},
  url          = {http://dx.doi.org/10.2967/jnumed.111.099408},
  volume       = {53},
  year         = {2012},
}