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Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort

Chuang, Shu-Chun; Norat, Teresa; Murphy, Neil; Olsen, Anja; Tjonneland, Anne; Overvad, Kim; Boutron-Ruault, Marie Christine; Perquier, Florence; Dartois, Laureen and Kaaks, Rudolf, et al. (2012) In American Journal of Clinical Nutrition 96(1). p.164-174
Abstract
Background: Previous studies have shown that high fiber intake is associated with lower mortality. However, little is known about the association of dietary fiber with specific causes of death other than cardiovascular disease (CVD). Objective: The aim of this study was to assess the relation between fiber intake, mortality, and cause-specific mortality in a large European prospective study of 452,7 I 7 men and women. Design: HRs and 95% CIs were estimated by using Cox proportional hazards models, stratified by age, sex, and center and adjusted for education, smoking, alcohol consumption, BMI, physical activity, total energy intake, and, in women, ever use of menopausal hormone therapy. Results: During a mean follow-up of 12.7 y, a total... (More)
Background: Previous studies have shown that high fiber intake is associated with lower mortality. However, little is known about the association of dietary fiber with specific causes of death other than cardiovascular disease (CVD). Objective: The aim of this study was to assess the relation between fiber intake, mortality, and cause-specific mortality in a large European prospective study of 452,7 I 7 men and women. Design: HRs and 95% CIs were estimated by using Cox proportional hazards models, stratified by age, sex, and center and adjusted for education, smoking, alcohol consumption, BMI, physical activity, total energy intake, and, in women, ever use of menopausal hormone therapy. Results: During a mean follow-up of 12.7 y, a total of 23,582 deaths were recorded. Fiber intake was inversely associated with total mortality (HRper (10-g/d) (increase): 0.90; 95% Cl: 0.88, 0.92); with mortality from circulatory (HRper (10-g/d increase): 0.90 and 0.88 for men and women, respectively), digestive (HR: 0.61 and 0.64), respiratory (HR: 0.77 and 0.62), and non-CVD noncancer inflammatory (HR: 0.85 and 0.80) diseases; and with smoking-related cancers (HR: 0.86 and 0.89) but not with non-smoking-related cancers (HR: 1.05 and 0.97). The associations were more evident for fiber from cereals and vegetables than from fruit. The associations were similar across BMI and physical activity categories but were stronger in smokers and participants who consumed >18 g alcohol/d. Conclusions: Higher fiber intake is associated with lower mortality, particularly from circulatory, digestive, and non-CVD noncancer inflammatory diseases. Our results support current recommendations of high dietary fiber intake for health maintenance. Am J Clin Nutr 2012;96:164-74. (Less)
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American Journal of Clinical Nutrition
volume
96
issue
1
pages
164 - 174
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000305670100021
  • scopus:84863601547
ISSN
1938-3207
DOI
10.3945/ajcn.111.028415
language
English
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yes
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98f05977-d96a-4b60-ac99-55960243c35f (old id 2863661)
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2012-08-01 09:43:02
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2017-11-05 03:52:35
@article{98f05977-d96a-4b60-ac99-55960243c35f,
  abstract     = {Background: Previous studies have shown that high fiber intake is associated with lower mortality. However, little is known about the association of dietary fiber with specific causes of death other than cardiovascular disease (CVD). Objective: The aim of this study was to assess the relation between fiber intake, mortality, and cause-specific mortality in a large European prospective study of 452,7 I 7 men and women. Design: HRs and 95% CIs were estimated by using Cox proportional hazards models, stratified by age, sex, and center and adjusted for education, smoking, alcohol consumption, BMI, physical activity, total energy intake, and, in women, ever use of menopausal hormone therapy. Results: During a mean follow-up of 12.7 y, a total of 23,582 deaths were recorded. Fiber intake was inversely associated with total mortality (HRper (10-g/d) (increase): 0.90; 95% Cl: 0.88, 0.92); with mortality from circulatory (HRper (10-g/d increase): 0.90 and 0.88 for men and women, respectively), digestive (HR: 0.61 and 0.64), respiratory (HR: 0.77 and 0.62), and non-CVD noncancer inflammatory (HR: 0.85 and 0.80) diseases; and with smoking-related cancers (HR: 0.86 and 0.89) but not with non-smoking-related cancers (HR: 1.05 and 0.97). The associations were more evident for fiber from cereals and vegetables than from fruit. The associations were similar across BMI and physical activity categories but were stronger in smokers and participants who consumed >18 g alcohol/d. Conclusions: Higher fiber intake is associated with lower mortality, particularly from circulatory, digestive, and non-CVD noncancer inflammatory diseases. Our results support current recommendations of high dietary fiber intake for health maintenance. Am J Clin Nutr 2012;96:164-74.},
  author       = {Chuang, Shu-Chun and Norat, Teresa and Murphy, Neil and Olsen, Anja and Tjonneland, Anne and Overvad, Kim and Boutron-Ruault, Marie Christine and Perquier, Florence and Dartois, Laureen and Kaaks, Rudolf and Teucher, Birgit and Bergmann, Manuela M. and Boeing, Heiner and Trichopoulou, Antonia and Lagiou, Pagona and Trichopoulos, Dimitrios and Grioni, Sara and Sacerdote, Carlotta and Panico, Salvatore and Palli, Domenico and Tumino, Rosario and Peeters, Petra H. M. and Bueno-de-Mesquita, Bas and Ros, Martine M. and Brustad, Magritt and Asli, Lene Angell and Skeie, Guri and Quiros, J. Ramon and Gonzalez, Carlos A. and Sanchez, Maria-Jose and Navarro, Carmen and Aicua, Eva Ardanaz and Dorronsoro, Miren and Drake, Isabel and Sonestedt, Emily and Johansson, Ingegerd and Hallmans, Goeran and Key, Timothy and Crowe, Francesca and Khaw, Kay-Tee and Wareham, Nicholas and Ferrari, Pietro and Slimani, Nadia and Romieu, Isabelle and Gallo, Valentina and Riboli, Elio and Vineis, Paolo},
  issn         = {1938-3207},
  language     = {eng},
  number       = {1},
  pages        = {164--174},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort},
  url          = {http://dx.doi.org/10.3945/ajcn.111.028415},
  volume       = {96},
  year         = {2012},
}