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The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight

Linninge, Caroline LU ; Önnerfält, Jenny LU ; Xu, Jie LU ; Molin, Göran LU ; Ahrné, Siv LU and Thorngren-Jerneck, Kristina LU (2012) In Obesity 20(11). p.2257-2261
Abstract
The aim of this study was to investigate the gut microbiota in preschool children with and without overweight and
obesity. Twenty overweight or obese children and twenty children with BMI within the normal range (age: 4–5 years)
were recruited from the south of Sweden. The gut microbiota was accessed by quantitative PCR (qPCR) and terminal
restriction fragment length polymorphism and calprotectin was measured in feces. Liver enzymes were quantified
in obese/overweight children. The concentration of the gram-negative family Enterobacteriaceae was significantly
higher in the obese/overweight children (P = 0.036), whereas levels of Desulfovibrio and Akkermansia muciniphilalike
bacteria were significantly lower in the... (More)
The aim of this study was to investigate the gut microbiota in preschool children with and without overweight and
obesity. Twenty overweight or obese children and twenty children with BMI within the normal range (age: 4–5 years)
were recruited from the south of Sweden. The gut microbiota was accessed by quantitative PCR (qPCR) and terminal
restriction fragment length polymorphism and calprotectin was measured in feces. Liver enzymes were quantified
in obese/overweight children. The concentration of the gram-negative family Enterobacteriaceae was significantly
higher in the obese/overweight children (P = 0.036), whereas levels of Desulfovibrio and Akkermansia muciniphilalike
bacteria were significantly lower in the obese/overweight children (P = 0.027 and P = 0.030, respectively). No
significant differences were found in content of Lactobacillus, Bifidobacterium or the Bacteroides fragilis group.
The diversity of the dominating bacterial community tended to be less diverse in the obese/overweight group, but
the difference was not statistically significant. Concentration of Bifidobacterium was inversely correlated to alanine
aminotransferase (ALT) in obese/overweight children. The fecal levels of calprotectin did not differ between the study
groups. These findings indicate that the gut microbiota differed among preschool children with obesity/overweight
compared with children with BMI within the normal range. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity
volume
20
issue
11
pages
2257 - 2261
publisher
Nature Publishing Group
external identifiers
  • scopus:84868197954
ISSN
1930-739X
DOI
10.1038/oby.2012.110
language
English
LU publication?
yes
id
29c959b8-4850-43fc-9e10-d2b16f3f55ca
date added to LUP
2016-10-03 21:09:34
date last changed
2017-11-05 05:07:42
@article{29c959b8-4850-43fc-9e10-d2b16f3f55ca,
  abstract     = {The aim of this study was to investigate the gut microbiota in preschool children with and without overweight and<br/>obesity. Twenty overweight or obese children and twenty children with BMI within the normal range (age: 4–5 years)<br/>were recruited from the south of Sweden. The gut microbiota was accessed by quantitative PCR (qPCR) and terminal<br/>restriction fragment length polymorphism and calprotectin was measured in feces. Liver enzymes were quantified<br/>in obese/overweight children. The concentration of the gram-negative family Enterobacteriaceae was significantly<br/>higher in the obese/overweight children (P = 0.036), whereas levels of Desulfovibrio and Akkermansia muciniphilalike<br/>bacteria were significantly lower in the obese/overweight children (P = 0.027 and P = 0.030, respectively). No<br/>significant differences were found in content of Lactobacillus, Bifidobacterium or the Bacteroides fragilis group.<br/>The diversity of the dominating bacterial community tended to be less diverse in the obese/overweight group, but<br/>the difference was not statistically significant. Concentration of Bifidobacterium was inversely correlated to alanine<br/>aminotransferase (ALT) in obese/overweight children. The fecal levels of calprotectin did not differ between the study<br/>groups. These findings indicate that the gut microbiota differed among preschool children with obesity/overweight<br/>compared with children with BMI within the normal range.},
  author       = {Linninge, Caroline and Önnerfält, Jenny and Xu, Jie and Molin, Göran and Ahrné, Siv and Thorngren-Jerneck, Kristina},
  issn         = {1930-739X},
  language     = {eng},
  number       = {11},
  pages        = {2257--2261},
  publisher    = {Nature Publishing Group},
  series       = {Obesity},
  title        = {The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight},
  url          = {http://dx.doi.org/10.1038/oby.2012.110},
  volume       = {20},
  year         = {2012},
}