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Decreased expression of brain-derived neurotrophic factor in BDNF(+/-) mice is associated with enhanced recovery of motor performance and increased neuroblast number following experimental stroke.

Nygren, Josefine LU ; Kokaia, Merab LU and Wieloch, Tadeusz LU (2006) In Journal of Neuroscience Research 84(3). p.626-631
Abstract
Brain-derived neurotrophic factor (BDNF) is involved in brain plasticity and neuronal survival. Generally, BDNF enhances synaptic activity and neurite growth, although the effect of BDNF on neuronal survival and brain plasticity following injury is equivocal. Housing rats in an enriched environment after experimental stroke enhances recovery of sensory-motor function, which is associated with a decrease in the BDNF mRNA and protein levels. We used BDNF+/- mice and wild-type littermate mice to investigate whether the decrease in the brain levels of BDNF affected motor function or infarct volume following transient occlusion of the middle cerebral artery (tMCAO) for 40 min. We found that the BDNF+/- mice had a significantly improved motor... (More)
Brain-derived neurotrophic factor (BDNF) is involved in brain plasticity and neuronal survival. Generally, BDNF enhances synaptic activity and neurite growth, although the effect of BDNF on neuronal survival and brain plasticity following injury is equivocal. Housing rats in an enriched environment after experimental stroke enhances recovery of sensory-motor function, which is associated with a decrease in the BDNF mRNA and protein levels. We used BDNF+/- mice and wild-type littermate mice to investigate whether the decrease in the brain levels of BDNF affected motor function or infarct volume following transient occlusion of the middle cerebral artery (tMCAO) for 40 min. We found that the BDNF+/- mice had a significantly improved motor function on the rotating pole test 2 weeks after tMCAO compared with wild-type mice. When intermittently exposed to an enriched environment following tMCAO, the wild-type mice improved motor function to the same degree as BDNF mice. There was no effect of BDNF reduction on infarct volume. Neurogenesis is induced following experimental stroke, and in the striatum of BDNF+/- mice significantly increased numbers of neuroblasts compared with wildtype mice were seen, both in standard and in enriched conditions. We conclude that decreasing brain levels of BDNF enhances the recovery of function following experimental stroke. (c) 2006 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neurotrophic factor, focal ischemia, brain-derived, neurogenesis, enriched environment
in
Journal of Neuroscience Research
volume
84
issue
3
pages
626 - 631
publisher
John Wiley & Sons
external identifiers
  • pmid:16770774
  • wos:000239584700016
  • scopus:33747020589
ISSN
1097-4547
DOI
10.1002/jnr.20956
language
English
LU publication?
yes
id
2ad081cb-7724-491b-8518-6ef2b422d417 (old id 158337)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16770774&dopt=Abstract
date added to LUP
2007-07-16 15:31:48
date last changed
2019-02-20 07:29:57
@article{2ad081cb-7724-491b-8518-6ef2b422d417,
  abstract     = {Brain-derived neurotrophic factor (BDNF) is involved in brain plasticity and neuronal survival. Generally, BDNF enhances synaptic activity and neurite growth, although the effect of BDNF on neuronal survival and brain plasticity following injury is equivocal. Housing rats in an enriched environment after experimental stroke enhances recovery of sensory-motor function, which is associated with a decrease in the BDNF mRNA and protein levels. We used BDNF+/- mice and wild-type littermate mice to investigate whether the decrease in the brain levels of BDNF affected motor function or infarct volume following transient occlusion of the middle cerebral artery (tMCAO) for 40 min. We found that the BDNF+/- mice had a significantly improved motor function on the rotating pole test 2 weeks after tMCAO compared with wild-type mice. When intermittently exposed to an enriched environment following tMCAO, the wild-type mice improved motor function to the same degree as BDNF mice. There was no effect of BDNF reduction on infarct volume. Neurogenesis is induced following experimental stroke, and in the striatum of BDNF+/- mice significantly increased numbers of neuroblasts compared with wildtype mice were seen, both in standard and in enriched conditions. We conclude that decreasing brain levels of BDNF enhances the recovery of function following experimental stroke. (c) 2006 Wiley-Liss, Inc.},
  author       = {Nygren, Josefine and Kokaia, Merab and Wieloch, Tadeusz},
  issn         = {1097-4547},
  keyword      = {neurotrophic factor,focal ischemia,brain-derived,neurogenesis,enriched environment},
  language     = {eng},
  number       = {3},
  pages        = {626--631},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Neuroscience Research},
  title        = {Decreased expression of brain-derived neurotrophic factor in BDNF(+/-) mice is associated with enhanced recovery of motor performance and increased neuroblast number following experimental stroke.},
  url          = {http://dx.doi.org/10.1002/jnr.20956},
  volume       = {84},
  year         = {2006},
}