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Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel

Dencker, Magnus LU ; Björgell, Ola LU and Hlebowicz, Joanna LU (2019) In BMC Research Notes 12(1).
Abstract

Objective: To evaluates the effect of food intake on 92 oncological biomarkers to evaluate whether the timing of blood sampling could be relevant. Twenty-two healthy subjects were investigated. A total of 92 biomarkers were measured before a standardised meal as well as 30 and 120 min afterwards with the Proseek Multiplex Oncology II kit. Results: The levels of 6 biomarkers decreased significantly (P < 0.001) 30 min after food intake, and 4 biomarkers remained decreased (P < 0.001) 120 min after food intake. One biomarker was significantly increased (P < 0.001) at both 30 and 120 min after food intake. Some changes were less than 10%. Those biomarkers that showed a difference of more than 10% include: Granzyme H (13%),... (More)

Objective: To evaluates the effect of food intake on 92 oncological biomarkers to evaluate whether the timing of blood sampling could be relevant. Twenty-two healthy subjects were investigated. A total of 92 biomarkers were measured before a standardised meal as well as 30 and 120 min afterwards with the Proseek Multiplex Oncology II kit. Results: The levels of 6 biomarkers decreased significantly (P < 0.001) 30 min after food intake, and 4 biomarkers remained decreased (P < 0.001) 120 min after food intake. One biomarker was significantly increased (P < 0.001) at both 30 and 120 min after food intake. Some changes were less than 10%. Those biomarkers that showed a difference of more than 10% include: Granzyme H (13%), Methionine aminopeptidase 2 (14%), Secretory carrier-associated membrane protein 3 (39%), FAS-associated death domain protein (41%), and Pancreatic prohormone (79%). This study shows that food intake has a very modest effect on 92 different oncological biomarkers. Trial registration National Library of Medicine trial registration number NCT01027507 (retrospectively registered on December 8, 2009)

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Olink, Proseek Oncology II
in
BMC Research Notes
volume
12
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85063808007
ISSN
1756-0500
DOI
10.1186/s13104-019-4237-9
language
English
LU publication?
yes
id
2b3deac8-e4ee-4b80-8166-ee37fae8fec5
date added to LUP
2019-04-23 11:27:58
date last changed
2019-05-14 04:53:49
@article{2b3deac8-e4ee-4b80-8166-ee37fae8fec5,
  abstract     = {<p>Objective: To evaluates the effect of food intake on 92 oncological biomarkers to evaluate whether the timing of blood sampling could be relevant. Twenty-two healthy subjects were investigated. A total of 92 biomarkers were measured before a standardised meal as well as 30 and 120 min afterwards with the Proseek Multiplex Oncology II kit. Results: The levels of 6 biomarkers decreased significantly (P &lt; 0.001) 30 min after food intake, and 4 biomarkers remained decreased (P &lt; 0.001) 120 min after food intake. One biomarker was significantly increased (P &lt; 0.001) at both 30 and 120 min after food intake. Some changes were less than 10%. Those biomarkers that showed a difference of more than 10% include: Granzyme H (13%), Methionine aminopeptidase 2 (14%), Secretory carrier-associated membrane protein 3 (39%), FAS-associated death domain protein (41%), and Pancreatic prohormone (79%). This study shows that food intake has a very modest effect on 92 different oncological biomarkers. Trial registration National Library of Medicine trial registration number NCT01027507 (retrospectively registered on December 8, 2009)</p>},
  articleno    = {199},
  author       = {Dencker, Magnus and Björgell, Ola and Hlebowicz, Joanna},
  issn         = {1756-0500},
  keyword      = {Olink,Proseek Oncology II},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {BMC Research Notes},
  title        = {Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel},
  url          = {http://dx.doi.org/10.1186/s13104-019-4237-9},
  volume       = {12},
  year         = {2019},
}