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Axonal growth in mesothelial chambers. The role of the distal nerve segment

Danielsen, N LU ; Dahlin, L B LU ; Lee, Y F and Lundborg, G LU (1983) In Scandinavian Journal of Plastic and Reconstructive Surgery 17(2). p.25-119
Abstract

An experimental model is presented for studying nerve regeneration over gaps of various lengths between the both ends of a severed nerve. After transferring left and right sciatic nerves of rat to the back, the gap between the two nerve ends could be bridged by a preformed, tube-shaped mesothelial chamber of a desired length. When the gap length was 10 mm or less, a well developed nerve structure was generated in the chamber between the nerve ends, and axons from the left sciatic nerve reinnervated muscles in the right limb via the right sciatic nerve. When the gap length was extended to 15 mm or more no such regeneration occurred. When no distal nerve end was introduced into the chamber, there was a limited growth into this chamber... (More)

An experimental model is presented for studying nerve regeneration over gaps of various lengths between the both ends of a severed nerve. After transferring left and right sciatic nerves of rat to the back, the gap between the two nerve ends could be bridged by a preformed, tube-shaped mesothelial chamber of a desired length. When the gap length was 10 mm or less, a well developed nerve structure was generated in the chamber between the nerve ends, and axons from the left sciatic nerve reinnervated muscles in the right limb via the right sciatic nerve. When the gap length was extended to 15 mm or more no such regeneration occurred. When no distal nerve end was introduced into the chamber, there was a limited growth into this chamber over only 5-6 mm. This "limited growth phenomenon" is discussed with respect to a lack of "trophic" or cellular support from a distal nerve segment. It is also proposed that the termination of growth, seen under these circumstances, may suggest a new principle for avoiding the development of neuromas after nerve transections.

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organization
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Contribution to journal
publication status
published
subject
keywords
Animals, Axons, Nerve Regeneration, Neuroma, Rats, Rats, Inbred Strains, Sciatic Nerve, Surgical Procedures, Operative, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
in
Scandinavian Journal of Plastic and Reconstructive Surgery
volume
17
issue
2
pages
25 - 119
publisher
Scandinavian University Press
external identifiers
  • scopus:0021051051
ISSN
0036-5556
language
English
LU publication?
yes
id
2ccff675-c8a2-4827-9086-dd5b2d147657
date added to LUP
2017-10-13 14:10:27
date last changed
2017-11-06 10:00:30
@article{2ccff675-c8a2-4827-9086-dd5b2d147657,
  abstract     = {<p>An experimental model is presented for studying nerve regeneration over gaps of various lengths between the both ends of a severed nerve. After transferring left and right sciatic nerves of rat to the back, the gap between the two nerve ends could be bridged by a preformed, tube-shaped mesothelial chamber of a desired length. When the gap length was 10 mm or less, a well developed nerve structure was generated in the chamber between the nerve ends, and axons from the left sciatic nerve reinnervated muscles in the right limb via the right sciatic nerve. When the gap length was extended to 15 mm or more no such regeneration occurred. When no distal nerve end was introduced into the chamber, there was a limited growth into this chamber over only 5-6 mm. This "limited growth phenomenon" is discussed with respect to a lack of "trophic" or cellular support from a distal nerve segment. It is also proposed that the termination of growth, seen under these circumstances, may suggest a new principle for avoiding the development of neuromas after nerve transections.</p>},
  author       = {Danielsen, N and Dahlin, L B and Lee, Y F and Lundborg, G},
  issn         = {0036-5556},
  keyword      = {Animals,Axons,Nerve Regeneration,Neuroma,Rats,Rats, Inbred Strains,Sciatic Nerve,Surgical Procedures, Operative,Journal Article,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, Non-P.H.S.,Research Support, U.S. Gov't, P.H.S.},
  language     = {eng},
  number       = {2},
  pages        = {25--119},
  publisher    = {Scandinavian University Press},
  series       = {Scandinavian Journal of Plastic and Reconstructive Surgery},
  title        = {Axonal growth in mesothelial chambers. The role of the distal nerve segment},
  volume       = {17},
  year         = {1983},
}