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Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study.

Wirfält, Elisabet LU ; Midthune, D ; Reedy, J ; Mitrou, P ; Flood, A ; Subar, A F ; Leitzmann, M ; Mouw, T ; Hollenbeck, A R and Schatzkin, A , et al. (2009) In European Journal of Clinical Nutrition 63. p.707-717
Abstract
Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal... (More)
Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal cancer incidence (multivariate hazard ratio, HR: 0.85; 95% confidence interval, CI: 0.76, 0.94), when compared to less salutary food choices. Both the vegetable and fruit pattern and a fat-reduced foods pattern were associated with reduced rectal cancer incidence in men. In women, a similar vegetable and fruit pattern was associated with colorectal cancer protection (age-adjusted HR: 0.82; 95% CI: 0.70, 0.95), but the association was not statistically significant in multivariate analysis.Conclusions:These results, together with findings from previous studies support the hypothesis that micronutrient dense, low-fat, high-fiber food patterns protect against colorectal cancer.European Journal of Clinical Nutrition advance online publication, 6 August 2008; doi:10.1038/ejcn.2008.40. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Clinical Nutrition
volume
63
pages
707 - 717
publisher
Nature Publishing Group
external identifiers
  • wos:000266572000001
  • pmid:18685556
  • scopus:67549121649
  • pmid:18685556
ISSN
1476-5640
DOI
10.1038/ejcn.2008.40
language
English
LU publication?
yes
id
2cfd6e6e-d6fa-497c-95fb-01eb38cea92d (old id 1223409)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18685556?dopt=Abstract
date added to LUP
2016-04-04 09:13:46
date last changed
2022-01-29 08:55:17
@article{2cfd6e6e-d6fa-497c-95fb-01eb38cea92d,
  abstract     = {{Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal cancer incidence (multivariate hazard ratio, HR: 0.85; 95% confidence interval, CI: 0.76, 0.94), when compared to less salutary food choices. Both the vegetable and fruit pattern and a fat-reduced foods pattern were associated with reduced rectal cancer incidence in men. In women, a similar vegetable and fruit pattern was associated with colorectal cancer protection (age-adjusted HR: 0.82; 95% CI: 0.70, 0.95), but the association was not statistically significant in multivariate analysis.Conclusions:These results, together with findings from previous studies support the hypothesis that micronutrient dense, low-fat, high-fiber food patterns protect against colorectal cancer.European Journal of Clinical Nutrition advance online publication, 6 August 2008; doi:10.1038/ejcn.2008.40.}},
  author       = {{Wirfält, Elisabet and Midthune, D and Reedy, J and Mitrou, P and Flood, A and Subar, A F and Leitzmann, M and Mouw, T and Hollenbeck, A R and Schatzkin, A and Kipnis, V}},
  issn         = {{1476-5640}},
  language     = {{eng}},
  pages        = {{707--717}},
  publisher    = {{Nature Publishing Group}},
  series       = {{European Journal of Clinical Nutrition}},
  title        = {{Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study.}},
  url          = {{http://dx.doi.org/10.1038/ejcn.2008.40}},
  doi          = {{10.1038/ejcn.2008.40}},
  volume       = {{63}},
  year         = {{2009}},
}