Cardiovascular disease-related hospitalization and mortality among persons with von Willebrand disease : A nationwide register study in Sweden
Holm, Elena LU ; Osooli, Mehdi LU
; Steen Carlsson, Katarina
LU
and Berntorp, Erik
LU
(2019)
In Haemophilia
25(1).
p.109-115
- Abstract
Introduction: It has been hypothesized that persons with von Willebrand disease (VWD) may be protected against arterial thrombosis despite having atherosclerosis. Aim: To calculate a nationwide estimate of the absolute and comparative burden of cardiovascular disease (CVD) hospitalization and mortality among persons with VWD using birthdate and sex-matched comparisons from the general population in Sweden. Methods: Persons with VWD regardless of the type and severity, diagnosed by a medical doctor, who lived in Sweden for some time during the observation period 1987 through 2008 were included. For each participant with VWD, up to five randomly selected birthdate- and sex-matched persons from general population were selected as controls.... (More)
Introduction: It has been hypothesized that persons with von Willebrand disease (VWD) may be protected against arterial thrombosis despite having atherosclerosis. Aim: To calculate a nationwide estimate of the absolute and comparative burden of cardiovascular disease (CVD) hospitalization and mortality among persons with VWD using birthdate and sex-matched comparisons from the general population in Sweden. Methods: Persons with VWD regardless of the type and severity, diagnosed by a medical doctor, who lived in Sweden for some time during the observation period 1987 through 2008 were included. For each participant with VWD, up to five randomly selected birthdate- and sex-matched persons from general population were selected as controls. Results: A total of 2790 participants with VWD including 888 male and 1902 female subjects and 13 938 controls were included. Overall, the hazard of CVD-related hospitalization was 1.3-fold (95% CI: 1.1, 1.5) among participants with VWD after adjusting for sex, birthdate, diabetes and cancer. However, they had a 0.4-fold (95% CI: 0.3, 0.6) hazard of CVD-related mortality compared to general population sample. Conclusions: In this nationwide, long-term register study with individually matched controls, we have been able to show that persons with VWD have a higher hospitalization rate due to CVD events. However, the mortality rates appear lower than in the control population. The latter finding is consistent with previous studies and indicates a protective effect of the clotting factor deficiency inherited with VWD.
(Less)
- author
- Holm, Elena
LU
; Osooli, Mehdi
LU
; Steen Carlsson, Katarina
LU
and Berntorp, Erik
LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cardiovascular disease, hospitalization, mortality, VWD
- in
- Haemophilia
- volume
- 25
- issue
- 1
- pages
- 109 - 115
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:30468283
- scopus:85057111641
- ISSN
- 1351-8216
- DOI
- 10.1111/hae.13642
- language
- English
- LU publication?
- yes
- id
- 2d16125c-7580-4ce6-a8ee-5f1099211e9a
- date added to LUP
- 2018-12-04 11:52:20
- date last changed
- 2025-12-11 02:24:42
@article{2d16125c-7580-4ce6-a8ee-5f1099211e9a,
abstract = {{<p>Introduction: It has been hypothesized that persons with von Willebrand disease (VWD) may be protected against arterial thrombosis despite having atherosclerosis. Aim: To calculate a nationwide estimate of the absolute and comparative burden of cardiovascular disease (CVD) hospitalization and mortality among persons with VWD using birthdate and sex-matched comparisons from the general population in Sweden. Methods: Persons with VWD regardless of the type and severity, diagnosed by a medical doctor, who lived in Sweden for some time during the observation period 1987 through 2008 were included. For each participant with VWD, up to five randomly selected birthdate- and sex-matched persons from general population were selected as controls. Results: A total of 2790 participants with VWD including 888 male and 1902 female subjects and 13 938 controls were included. Overall, the hazard of CVD-related hospitalization was 1.3-fold (95% CI: 1.1, 1.5) among participants with VWD after adjusting for sex, birthdate, diabetes and cancer. However, they had a 0.4-fold (95% CI: 0.3, 0.6) hazard of CVD-related mortality compared to general population sample. Conclusions: In this nationwide, long-term register study with individually matched controls, we have been able to show that persons with VWD have a higher hospitalization rate due to CVD events. However, the mortality rates appear lower than in the control population. The latter finding is consistent with previous studies and indicates a protective effect of the clotting factor deficiency inherited with VWD.</p>}},
author = {{Holm, Elena and Osooli, Mehdi and Steen Carlsson, Katarina and Berntorp, Erik}},
issn = {{1351-8216}},
keywords = {{cardiovascular disease; hospitalization; mortality; VWD}},
language = {{eng}},
number = {{1}},
pages = {{109--115}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Haemophilia}},
title = {{Cardiovascular disease-related hospitalization and mortality among persons with von Willebrand disease : A nationwide register study in Sweden}},
url = {{http://dx.doi.org/10.1111/hae.13642}},
doi = {{10.1111/hae.13642}},
volume = {{25}},
year = {{2019}},
}