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Glycosaminoglycans: a link between development and regeneration in the lung : a link between development and regeneration in the lung

Wigén, Jenny Cecilia LU ; Elowsson Rendin, Linda LU ; Karlsson, Lisa LU ; Tykesson, Emil LU and Westergren-Thorsson, Gunilla LU (2019) In Stem Cells and Development 28(13). p.823-832
Abstract

What can we learn from embryogenesis to increase our understanding of how regeneration of damaged adult lung tissue could be induced in serious lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and asthma? The local tissue niche determines events in both embryogenesis and repair of the adult lung. Important constituents of the niche are extracellular matrix (ECM) molecules including proteoglycans and glycosaminoglycans (GAG). GAGs, strategically located in the pericellular and extracellular space, bind developmentally active growth factors and morphogenes such as fibroblast growth factors (FGF), transforming growth factor- (TGF-) and bone morphogenetic proteins (BMPs) aside from... (More)

What can we learn from embryogenesis to increase our understanding of how regeneration of damaged adult lung tissue could be induced in serious lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and asthma? The local tissue niche determines events in both embryogenesis and repair of the adult lung. Important constituents of the niche are extracellular matrix (ECM) molecules including proteoglycans and glycosaminoglycans (GAG). GAGs, strategically located in the pericellular and extracellular space, bind developmentally active growth factors and morphogenes such as fibroblast growth factors (FGF), transforming growth factor- (TGF-) and bone morphogenetic proteins (BMPs) aside from cytokines. These interactions affect activities in many cells, including stem cells, important in development and tissue regeneration. Moreover, it is becoming clear that the "inherent code", such as sulfation of disaccharides of GAGs is a strong determinant of cellular outcome. Sulfation pattern, deacetylations and epimerizations of GAG chains function as tuning forks in gradient formation of morphogens, growth factors and cytokines. Learning to tune these fine instruments, i.e. interactions between growth factors (GF), chemokines and cytokines with the specific disaccharide code of GAGs in the adult lung, could become the key to unlock inherent regenerative forces to override pathological remodeling. This review aims to give an overview of the role GAGs play during development and similar events in regenerative efforts in the adult lung.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Stem Cells and Development
volume
28
issue
13
pages
10 pages
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:31062651
  • scopus:85068314157
ISSN
1557-8534
DOI
10.1089/scd.2019.0009
language
English
LU publication?
yes
id
2d586033-cbc4-4784-b21e-e9fbbd7952a5
date added to LUP
2019-05-20 15:24:33
date last changed
2019-08-06 03:19:37
@article{2d586033-cbc4-4784-b21e-e9fbbd7952a5,
  abstract     = {<p>What can we learn from embryogenesis to increase our understanding of how regeneration of damaged adult lung tissue could be induced in serious lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and asthma? The local tissue niche determines events in both embryogenesis and repair of the adult lung. Important constituents of the niche are extracellular matrix (ECM) molecules including proteoglycans and glycosaminoglycans (GAG). GAGs, strategically located in the pericellular and extracellular space, bind developmentally active growth factors and morphogenes such as fibroblast growth factors (FGF), transforming growth factor- (TGF-) and bone morphogenetic proteins (BMPs) aside from cytokines. These interactions affect activities in many cells, including stem cells, important in development and tissue regeneration. Moreover, it is becoming clear that the "inherent code", such as sulfation of disaccharides of GAGs is a strong determinant of cellular outcome. Sulfation pattern, deacetylations and epimerizations of GAG chains function as tuning forks in gradient formation of morphogens, growth factors and cytokines. Learning to tune these fine instruments, i.e. interactions between growth factors (GF), chemokines and cytokines with the specific disaccharide code of GAGs in the adult lung, could become the key to unlock inherent regenerative forces to override pathological remodeling. This review aims to give an overview of the role GAGs play during development and similar events in regenerative efforts in the adult lung.</p>},
  author       = {Wigén, Jenny Cecilia and Elowsson Rendin, Linda and Karlsson, Lisa and Tykesson, Emil and Westergren-Thorsson, Gunilla},
  issn         = {1557-8534},
  language     = {eng},
  month        = {06},
  number       = {13},
  pages        = {823--832},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Stem Cells and Development},
  title        = {Glycosaminoglycans: a link between development and regeneration in the lung : a link between development and regeneration in the lung},
  url          = {http://dx.doi.org/10.1089/scd.2019.0009},
  doi          = {10.1089/scd.2019.0009},
  volume       = {28},
  year         = {2019},
}