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Expression and localization of serotonin receptors in human breast cancer.

Kopparapu, Pradeep Kumar; Tinzl, Martina LU ; Anagnostaki, Lola; Persson, Jenny Liao LU and Dizeyi, Nishtman LU (2013) In Anticancer research 33(2). p.363-370
Abstract
The aim of this study was to examine the expression of serotonin receptors in patients with breast cancer and to explore their utility as diagnostic and prognostic markers. Immunohistochemical analysis was performed to examine the expression of serotonin (5-HT) receptor subtypes 1A, 1B, 2B and 4 in a tissue microarray containing tumor specimens from 102 patients. Statistical analysis was performed to correlate the expression of these proteins with regard to clinical parameters. We found that all four serotonin receptors (5-HTRs) exhibited different expression patterns in breast cancer specimens. In general strong staining for 5-HTR1A was observed on the membrane of cancer cells but it was detected only in the cytoplasm of non-malignant... (More)
The aim of this study was to examine the expression of serotonin receptors in patients with breast cancer and to explore their utility as diagnostic and prognostic markers. Immunohistochemical analysis was performed to examine the expression of serotonin (5-HT) receptor subtypes 1A, 1B, 2B and 4 in a tissue microarray containing tumor specimens from 102 patients. Statistical analysis was performed to correlate the expression of these proteins with regard to clinical parameters. We found that all four serotonin receptors (5-HTRs) exhibited different expression patterns in breast cancer specimens. In general strong staining for 5-HTR1A was observed on the membrane of cancer cells but it was detected only in the cytoplasm of non-malignant cells. 5-HTR1B and 5-HTR2B were predominantly expressed in the cytoplasm of breast cancer cells, while 5-HTR4 was exclusively found in the nucleus of malignant and non-malignant cells. Correlation analysis revealed a significant correlation of 5-HTR2B with estrogen receptor-α (ER-α) and 5-HTR4 with ER-α and progesterone (PR). In conclusion, the different expression patterns and subcellular localization of 5-HTRs in breast cancer may reflect their role in breast cancer progression. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anticancer research
volume
33
issue
2
pages
363 - 370
publisher
International Institute of Cancer Research
external identifiers
  • wos:000315424000003
  • pmid:23393325
  • scopus:84875893256
ISSN
1791-7530
language
English
LU publication?
yes
id
2e44962c-6edd-463d-840d-0cecaa7dadaa (old id 3560013)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23393325?dopt=Abstract
date added to LUP
2013-03-01 13:40:13
date last changed
2019-02-20 01:08:58
@article{2e44962c-6edd-463d-840d-0cecaa7dadaa,
  abstract     = {The aim of this study was to examine the expression of serotonin receptors in patients with breast cancer and to explore their utility as diagnostic and prognostic markers. Immunohistochemical analysis was performed to examine the expression of serotonin (5-HT) receptor subtypes 1A, 1B, 2B and 4 in a tissue microarray containing tumor specimens from 102 patients. Statistical analysis was performed to correlate the expression of these proteins with regard to clinical parameters. We found that all four serotonin receptors (5-HTRs) exhibited different expression patterns in breast cancer specimens. In general strong staining for 5-HTR1A was observed on the membrane of cancer cells but it was detected only in the cytoplasm of non-malignant cells. 5-HTR1B and 5-HTR2B were predominantly expressed in the cytoplasm of breast cancer cells, while 5-HTR4 was exclusively found in the nucleus of malignant and non-malignant cells. Correlation analysis revealed a significant correlation of 5-HTR2B with estrogen receptor-α (ER-α) and 5-HTR4 with ER-α and progesterone (PR). In conclusion, the different expression patterns and subcellular localization of 5-HTRs in breast cancer may reflect their role in breast cancer progression.},
  author       = {Kopparapu, Pradeep Kumar and Tinzl, Martina and Anagnostaki, Lola and Persson, Jenny Liao and Dizeyi, Nishtman},
  issn         = {1791-7530},
  language     = {eng},
  number       = {2},
  pages        = {363--370},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer research},
  title        = {Expression and localization of serotonin receptors in human breast cancer.},
  volume       = {33},
  year         = {2013},
}