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Evaluation of image reconstruction methods for 123I-MIBG-SPECT: a rank-order study.

Söderberg, Marcus LU ; Mattsson, Sören LU ; Oddstig, Jenny LU ; Uusijärvi, Helena LU ; Valind, Sven LU ; Thorsson, Ola LU ; Garpered, Sabine LU ; Prautzsch, Tilmann; Tischenko, Oleg and Leide Svegborn, Sigrid LU (2012) In Acta Radiologica 53(7). p.778-784
Abstract
Background:

There is an opportunity to improve the image quality and lesion detectability in single photon emission computed tomography (SPECT) by choosing an appropriate reconstruction method and optimal parameters for the reconstruction.



Purpose:

To optimize the use of the Flash 3D reconstruction algorithm in terms of equivalent iteration (EI) number (number of subsets times the number of iterations) and to compare with two recently developed reconstruction algorithms ReSPECT and orthogonal polynomial expansion on disc (OPED) for application on (123)I-metaiodobenzylguanidine (MIBG)-SPECT.



Material and Methods:

Eleven adult patients underwent SPECT 4 h and 14 patients 24 h... (More)
Background:

There is an opportunity to improve the image quality and lesion detectability in single photon emission computed tomography (SPECT) by choosing an appropriate reconstruction method and optimal parameters for the reconstruction.



Purpose:

To optimize the use of the Flash 3D reconstruction algorithm in terms of equivalent iteration (EI) number (number of subsets times the number of iterations) and to compare with two recently developed reconstruction algorithms ReSPECT and orthogonal polynomial expansion on disc (OPED) for application on (123)I-metaiodobenzylguanidine (MIBG)-SPECT.



Material and Methods:

Eleven adult patients underwent SPECT 4 h and 14 patients 24 h after injection of approximately 200 MBq (123)I-MIBG using a Siemens Symbia T6 SPECT/CT. Images were reconstructed from raw data using the Flash 3D algorithm at eight different EI numbers. The images were ranked by three experienced nuclear medicine physicians according to their overall impression of the image quality. The obtained optimal images were then compared in one further visual comparison with images reconstructed using the ReSPECT and OPED algorithms.ResultsThe optimal EI number for Flash 3D was determined to be 32 for acquisition 4 h and 24 h after injection. The average rank order (best first) for the different reconstructions for acquisition after 4 h was: Flash 3D(32) > ReSPECT > Flash 3D(64) > OPED, and after 24 h: Flash 3D(16) > ReSPECT > Flash 3D(32) > OPED. A fair level of inter-observer agreement concerning optimal EI number and reconstruction algorithm was obtained, which may be explained by the different individual preferences of what is appropriate image quality.



Conclusion:

Using Siemens Symbia T6 SPECT/CT and specified acquisition parameters, Flash 3D(32) (4 h) and Flash 3D(16) (24 h), followed by ReSPECT, were assessed to be the preferable reconstruction algorithms in visual assessment of (123)I-MIBG images. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
image reconstruction, SPECT, iterative method, analytic method, human, observer
in
Acta Radiologica
volume
53
issue
7
pages
778 - 784
publisher
John Wiley & Sons
external identifiers
  • wos:000309624700013
  • pmid:22847902
  • scopus:84866559060
ISSN
1600-0455
DOI
10.1258/ar.2012.120078
language
English
LU publication?
yes
id
bff7f21a-9ec2-4882-9462-52aacfd9a9f0 (old id 3047918)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22847902?dopt=Abstract
date added to LUP
2012-09-03 21:42:28
date last changed
2017-01-01 05:42:11
@article{bff7f21a-9ec2-4882-9462-52aacfd9a9f0,
  abstract     = {Background:<br/><br>
There is an opportunity to improve the image quality and lesion detectability in single photon emission computed tomography (SPECT) by choosing an appropriate reconstruction method and optimal parameters for the reconstruction.<br/><br>
<br/><br>
Purpose:<br/><br>
To optimize the use of the Flash 3D reconstruction algorithm in terms of equivalent iteration (EI) number (number of subsets times the number of iterations) and to compare with two recently developed reconstruction algorithms ReSPECT and orthogonal polynomial expansion on disc (OPED) for application on (123)I-metaiodobenzylguanidine (MIBG)-SPECT.<br/><br>
<br/><br>
Material and Methods:<br/><br>
Eleven adult patients underwent SPECT 4 h and 14 patients 24 h after injection of approximately 200 MBq (123)I-MIBG using a Siemens Symbia T6 SPECT/CT. Images were reconstructed from raw data using the Flash 3D algorithm at eight different EI numbers. The images were ranked by three experienced nuclear medicine physicians according to their overall impression of the image quality. The obtained optimal images were then compared in one further visual comparison with images reconstructed using the ReSPECT and OPED algorithms.ResultsThe optimal EI number for Flash 3D was determined to be 32 for acquisition 4 h and 24 h after injection. The average rank order (best first) for the different reconstructions for acquisition after 4 h was: Flash 3D(32) &gt; ReSPECT &gt; Flash 3D(64) &gt; OPED, and after 24 h: Flash 3D(16) &gt; ReSPECT &gt; Flash 3D(32) &gt; OPED. A fair level of inter-observer agreement concerning optimal EI number and reconstruction algorithm was obtained, which may be explained by the different individual preferences of what is appropriate image quality.<br/><br>
<br/><br>
Conclusion:<br/><br>
Using Siemens Symbia T6 SPECT/CT and specified acquisition parameters, Flash 3D(32) (4 h) and Flash 3D(16) (24 h), followed by ReSPECT, were assessed to be the preferable reconstruction algorithms in visual assessment of (123)I-MIBG images.},
  author       = {Söderberg, Marcus and Mattsson, Sören and Oddstig, Jenny and Uusijärvi, Helena and Valind, Sven and Thorsson, Ola and Garpered, Sabine and Prautzsch, Tilmann and Tischenko, Oleg and Leide Svegborn, Sigrid},
  issn         = {1600-0455},
  keyword      = {image reconstruction,SPECT,iterative method,analytic method,human,observer},
  language     = {eng},
  number       = {7},
  pages        = {778--784},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Evaluation of image reconstruction methods for 123I-MIBG-SPECT: a rank-order study.},
  url          = {http://dx.doi.org/10.1258/ar.2012.120078},
  volume       = {53},
  year         = {2012},
}