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Complete metabolic response with [18F]fluorodeoxyglucose-positron emission tomography/computed tomography predicts survival following induction chemotherapy and radical cystectomy in clinically lymph node positive bladder cancer

Abrahamsson, Johan LU ; Kollberg, Petter LU ; Almquist, Helen LU ; Bläckberg, Mats LU ; Brändstedt, Johan LU ; Lyttkens, Kerstin LU ; Simoulis, Athanasios LU orcid ; Sjödahl, Gottfrid LU ; Sörenby, Anne LU and Trägårdh, Elin LU orcid , et al. (2022) In BJU International 129(2). p.174-181
Abstract

Objective: To determine whether repeated [18F]fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET-CT) scans can predict increased cancer-specific survival (CSS) after induction chemotherapy followed by radical cystectomy (RC). Patients and Methods: Between 2007 and 2018, 86 patients with clinically lymph node (LN)-positive bladder cancer (T1–T4, N1–N3, M0–M1a) were included and underwent a repeated FDG-PET-CT during cisplatin-based induction chemotherapy. The 71 patients that had a response to chemotherapy underwent RC. Response to chemotherapy was evaluated in LNs through repeated FDG-PET-CT and stratified as partial response or complete response using three different methods: maximum standardised... (More)

Objective: To determine whether repeated [18F]fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET-CT) scans can predict increased cancer-specific survival (CSS) after induction chemotherapy followed by radical cystectomy (RC). Patients and Methods: Between 2007 and 2018, 86 patients with clinically lymph node (LN)-positive bladder cancer (T1–T4, N1–N3, M0–M1a) were included and underwent a repeated FDG-PET-CT during cisplatin-based induction chemotherapy. The 71 patients that had a response to chemotherapy underwent RC. Response to chemotherapy was evaluated in LNs through repeated FDG-PET-CT and stratified as partial response or complete response using three different methods: maximum standardised uptake value (SUVmax), adapted Deauville criteria, and total lesion glycolysis (TLG). Progression-free survival (PFS) and CSS were analysed for all three methods by Cox regression analysis. Results: After a median follow-up of 40 months, 15 of the 71 patients who underwent RC had died from bladder cancer. Using SUVmax and the adapted Deauville criteria, multivariable Cox regression analyses adjusting for age, clinical tumour stage and LN stage showed that complete response was associated with increased PFS (hazard ratio [HR] 3.42, 95% confidence interval [CI] 1.20–9.77) and CSS (HR 3.30, 95% CI 1.02–10.65). Using TLG, a complete response was also associated with increased PFS (HR 5.17, 95% CI 1.90–14.04) and CSS (HR 6.32, 95% CI 2.06–19.41). Conclusions: Complete metabolic response with FDG-PET-CT predicts survival after induction chemotherapy followed by RC in patients with LN-positive bladder cancer and comprises a novel tool in evaluating response to chemotherapy before surgery. This strategy has the potential to tailor treatment in individual patients by identifying significant response to chemotherapy, which motivates the administration of a full course of induction chemotherapy with a higher threshold for suspending treatment due to toxicity and side-effects.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
#BladderCancer, #blcsm, #uroonc, bladder cancer, FDG-PET-CT, induction chemotherapy, lymph node positive, radical cystectomy, survival
in
BJU International
volume
129
issue
2
pages
174 - 181
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:33626220
  • scopus:85104729758
ISSN
1464-4096
DOI
10.1111/bju.15374
language
English
LU publication?
yes
id
305bafd9-7a79-47ab-a4a4-6fb92266049c
date added to LUP
2021-05-11 14:33:53
date last changed
2025-03-23 14:54:09
@article{305bafd9-7a79-47ab-a4a4-6fb92266049c,
  abstract     = {{<p>Objective: To determine whether repeated [<sup>18</sup>F]fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET-CT) scans can predict increased cancer-specific survival (CSS) after induction chemotherapy followed by radical cystectomy (RC). Patients and Methods: Between 2007 and 2018, 86 patients with clinically lymph node (LN)-positive bladder cancer (T1–T4, N1–N3, M0–M1a) were included and underwent a repeated FDG-PET-CT during cisplatin-based induction chemotherapy. The 71 patients that had a response to chemotherapy underwent RC. Response to chemotherapy was evaluated in LNs through repeated FDG-PET-CT and stratified as partial response or complete response using three different methods: maximum standardised uptake value (SUV<sub>max</sub>), adapted Deauville criteria, and total lesion glycolysis (TLG). Progression-free survival (PFS) and CSS were analysed for all three methods by Cox regression analysis. Results: After a median follow-up of 40 months, 15 of the 71 patients who underwent RC had died from bladder cancer. Using SUV<sub>max</sub> and the adapted Deauville criteria, multivariable Cox regression analyses adjusting for age, clinical tumour stage and LN stage showed that complete response was associated with increased PFS (hazard ratio [HR] 3.42, 95% confidence interval [CI] 1.20–9.77) and CSS (HR 3.30, 95% CI 1.02–10.65). Using TLG, a complete response was also associated with increased PFS (HR 5.17, 95% CI 1.90–14.04) and CSS (HR 6.32, 95% CI 2.06–19.41). Conclusions: Complete metabolic response with FDG-PET-CT predicts survival after induction chemotherapy followed by RC in patients with LN-positive bladder cancer and comprises a novel tool in evaluating response to chemotherapy before surgery. This strategy has the potential to tailor treatment in individual patients by identifying significant response to chemotherapy, which motivates the administration of a full course of induction chemotherapy with a higher threshold for suspending treatment due to toxicity and side-effects.</p>}},
  author       = {{Abrahamsson, Johan and Kollberg, Petter and Almquist, Helen and Bläckberg, Mats and Brändstedt, Johan and Lyttkens, Kerstin and Simoulis, Athanasios and Sjödahl, Gottfrid and Sörenby, Anne and Trägårdh, Elin and Liedberg, Fredrik}},
  issn         = {{1464-4096}},
  keywords     = {{#BladderCancer; #blcsm; #uroonc; bladder cancer; FDG-PET-CT; induction chemotherapy; lymph node positive; radical cystectomy; survival}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{174--181}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{BJU International}},
  title        = {{Complete metabolic response with [<sup>18</sup>F]fluorodeoxyglucose-positron emission tomography/computed tomography predicts survival following induction chemotherapy and radical cystectomy in clinically lymph node positive bladder cancer}},
  url          = {{http://dx.doi.org/10.1111/bju.15374}},
  doi          = {{10.1111/bju.15374}},
  volume       = {{129}},
  year         = {{2022}},
}